Navigation Links
Scientists ID 'Jekyll-Hyde' Protein in Lou Gehrig's Disease
Date:7/29/2008

Gene mutations cause superoxide dismutase to clump up in motor neurons

TUESDAY, July 29 (HealthDay News) -- A protein dysfunction could help drive amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, according to a study by researchers at Brandeis University and Harvard Medical School.

ALS is a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord that control muscle movement. In this study, researchers focused on the rare, familial form of ALS (fALS) as a way of better understanding the sporadic form of ALS, which accounts for 90 percent of all cases. Clinical symptoms are identical in both forms of the disease.

About 15 years ago, scientists found that mutations in the gene that makes the protein superoxide dismutase caused familial ALS, but just how these mutations cause ALS has remained a mystery.

In this new study, researchers found that fALS is caused by two properties of superoxide dismutase that create toxic levels of the protein in motor neurons.

"We discovered that increased protein unfolding and the propensity of the proteins to aggregate (clump together) are the major factors in the familial form of ALS," Brandeis chemist Jeff Agar said in a university news release.

"The protein superoxide dismutase, normally a useful antioxidant, goes from Dr. Jekyll to Mr. Hyde when it clumps up," Agar said.

The study was published this week in the journal PLoS Biology.

The next phase of this research is to develop drugs that prevent superoxide dismutase from clumping together.

More information

The Muscular Dystrophy Association has more about ALS.



-- Robert Preidt



SOURCE: Brandeis University, news release
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... It’s very easy to become overwhelmed with ... put to the wayside until Christmas and the New Year ... “itch” and that burning desire to just escape it all ... journey to Telluride with a no-fuss, affordable package. Montrose Days ... the resort, and ensure that all accommodations are met. Plus, ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Sub Zero Ice ... sponsor a blood drive Sunday the 28th from 2pm-6pm at ... & Sawyer Road in Sarasota, FL. , Inquiries regarding time ... you for participating in the donating process, Sub Zero Ice ... flash frozen, custom ice cream. , About Sub Zero Ice ...
(Date:12/19/2014)... The Plantrician Project , ... events, tools and resources for healthcare professionals and ... the world’s leading online cooking school, have joined ... needs: Culinary Rx. As an online food and ... scheduled for debut spring 2015, will be designed ...
(Date:12/19/2014)... Rosa, CA (PRWEB) December 19, 2014 ... and 5x5 SuperClone Rooms. SuperCloset continues to offer indoor ... solutions. Pair one of the new SuperClone Rooms with ... professional, perpetual, and turnkey indoor hydroponic grow room setup. ... in the world, SuperCloset’s SuperPonic SuperCloner 50 . ...
(Date:12/19/2014)... These vanadium reserves are mostly found in China, ... of vanadium were produced globally in 2013, up 11% ... 6.7% AAGR during the period from 2001 to 2013, ... largest consumer, accounted for more than 90% of total ... the chemical industry. , View Full Report at ...
Breaking Medicine News(10 mins):Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3
... from NewYork-Presbyterian Hospital/Weill Cornell Medical Center will present ... Association,s Annual Meeting in San Francisco, May 29 ... a urologist and professor of urology at NewYork-Presbyterian ... senior author and professor emeritus of urology at ...
... A minimally invasive technique used to destroy kidney tumors ... as surgical removal of tumors in curbing cancer recurrence ... In an article available online in the journal ... radiology at UT Southwestern Medical Center, reported the outcomes ...
... (BRONX, NY) The National Institutes of Health ... Medicine of Yeshiva University a five-year, $3.9 million grant ... in rural South Africa. The findings could alter public ... developing world. "Most cases of XDR-TB are thought ...
... ... demanding enterprise customers with VMware and Microsoft Hyper-V environments. , ... (PRWEB) June 2, 2010 -- VKernel, the ... announced today the general availability of VKernel Optimization Pack 1.4. The latest version ...
... aggressive ones, found in heaviest men, study says , WEDNESDAY, ... patients appears to be linked to patient weight, with heavier ... The finding stems from work involving more than 3,300 prostate ... surgery between 2001 and 2007 to remove a malignant prostate ...
... Risk aversion isn,t inevitable part of aging, researchers find ... says older people make less risky -- and less ... otherwise. , In some cases, older people make just ... people, researchers report. , "It,s not age, per se, ...
Cached Medicine News:Health News:NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting 2Health News:NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting 3Health News:Ablation proved as effective as traditional surgery in treating kidney cancer 2Health News:Einstein awarded NIH grant to study drug-resistant TB 2Health News:Einstein awarded NIH grant to study drug-resistant TB 3Health News:VKernel Raises Scalability and Reporting Bar with Optimization Pack 1.4 2Health News:Size of Prostate Tumor Linked to Patients' Weight 2Health News:Grandpa's Decision-Making Skills May Be Just Fine 2
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
(Date:12/19/2014)... Dec. 18, 2014 Capnia, Inc. (NASDAQ: ... of medical diagnostics based on its proprietary Sensalyze™ ... today announced financial results for the third quarter ... "Following the completion of our initial public ... maximize the recently initiated CoSense® commercial launch," said ...
(Date:12/19/2014)... and LYON, France , Dec. ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ... developing an ultra-rapid insulin, known as BioChaperone Lispro, for ... diabetes. BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology ... Lilly and Adocia will develop BioChaperone Lispro with the ...
Breaking Medicine Technology:The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
... and VANCOUVER, British Columbia, Feb. 28, 2011 ... announced today that Scott Cormack, OncoGenex,s president and chief ... on novel cancer treatments at the upcoming RBC Capital ... Treatments: Under the Radar Unique Late-Stage Opportunities ", will ...
... REDWOOD CITY, Calif., Feb. 28, 2011 At the ... Inc. (Nasdaq: CDXS ) will announce significant ... carbon dioxide emissions from coal-fired power plants.  The program ... Coal-fired power plants are major emitters of carbon dioxide, ...
Cached Medicine Technology:OncoGenex Pharmaceuticals to Participate in Panel Discussion on Novel Cancer Treatments at RBC Capital Markets Healthcare Conference 2Codexis Announces Carbon Capture Progress at ARPA-E Summit 2Codexis Announces Carbon Capture Progress at ARPA-E Summit 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: