Navigation Links
Scientists ID Gene for Insulin Sensitivity
Date:9/12/2012

WEDNESDAY, Sept. 12 (HealthDay News) -- Scientists have discovered the single gene that causes insulin sensitivity, which they say might someday help lead to new diabetes treatment.

Insulin sensitivity refers to how well the body uses insulin -- a hormone -- to regulate glucose (sugar) in the blood. The opposite is insulin resistance, which means the body does not use insulin properly.

"Insulin resistance is a major feature of type 2 diabetes. The insulin-producing cells in the pancreas may be working hard and pumping out lots of insulin, but the body's cells no longer respond," study leader Dr. Anna Gloyn, at the Oxford Centre for Diabetes, Endocrinology and Metabolism, explained in an Oxford University news release. "Finding a genetic cause of the opposite -- insulin sensitivity -- gives us a new window on the biological processes involved. Such understanding could be important in developing new drugs that restore insulin sensitivity in type 2 diabetes."

The researchers from Oxford University, the Babraham Institute in Cambridge and the Churchill Hospital in Oxford performed glucose tolerance tests on 15 healthy people and 15 otherwise similar people with Cowden syndrome, a rare condition caused by mutations in the PTEN gene. Cowden syndrome results in benign polyps in the skin, mouth and bowel that increase the risk for breast, thyroid and uterine cancer.

"PTEN is a gene that is heavily involved in processes for both cell growth and metabolism," study first author Dr. Aparna Pal, of the University of Oxford, explained in the news release. "Given PTEN's dual role, we were interested in understanding the metabolic profile of people with Cowden syndrome. It was possible that mutations in PTEN could improve metabolism."

The study revealed the people with Cowden syndrome had significantly higher insulin sensitivity. This was the result of heightened activity in the insulin-signaling pathway, according to the researchers. They added that participants with Cowden syndrome had higher body-mass index scores -- a measure of body fat -- than the others.

After expanding the comparison to more than 2,000 people from an Oxford database, the researchers confirmed that people with Cowden syndrome had more fat and higher rates of obesity.

"This was a surprise. Normally insulin sensitivity goes with being lean," said Professor Fredrik Karpe, who established the Oxford database.

Exercise and a healthy diet remain the best ways to avoid diabetes, the researchers stressed. If left untreated, the disease can lead to heart disease, stroke, nerve damage and blindness.

The study appears in the Sept. 13 issue of the New England Journal of Medicine.

More information

The American Diabetes Association has more about diabetes.

-- Mary Elizabeth Dallas

SOURCE: Oxford University, news release, Sept. 12, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
2. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
3. Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
4. Reconstructed 1918 influenza virus has yielded key insights, scientists say
5. Scientists put a pox on dog cancer
6. MBL and Stanford scientists receive 2012 Lasker Award for Basic Medical Research
7. Scientists Inch Closer to Genetic Blueprint of Diseases
8. Scientists Find Links Among Parkinsons, Cancer and Family History
9. Danish scientists solve old blood mystery
10. First validated method for analyzing flavanols and procyanidins in cocoa products could help scientists and the industry in standardized reporting
11. Scientists ID Happy Gene in Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Gene for Insulin Sensitivity 
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... been named one of Michigan’s 2017 Best and Brightest in Wellness® by Best ... in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... at the University of California Berkeley, and other leading institutions in announcing the ... power of institutions to change the way animals are raised for food. , ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... ZirMed Inc ., a recognized leader in cloud-based revenue cycle ... ranked #1 by its users for the seventh consecutive year ... ZirMed was recognized as the top-ranked end-to-end revenue cycle management ... 200 beds and holds one of the longest #1 ranking ... ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 /PRNewswire/ ... ratings for global supply chains, has published the first annual edition of ... performance of more than 20,400 companies evaluated by EcoVadis, based on Scorecard ... and 2016. ... Global CSR Risk & Performance Index ...
Breaking Medicine Technology: