Navigation Links
Scientists ID Gene That Shows Progression in ALS Patients
Date:12/12/2012

WEDNESDAY, Dec. 12 (HealthDay News) -- A gene that's an indicator of disease progression in most patients with amyotrophic lateral sclerosis (ALS) has been identified by researchers.

ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that slowly causes paralysis and death. It affects about five in 100,000 people and there is no known cure.

The researchers at the Methodist Hospital in Houston found that the debilitating symptoms of ALS appear to be increased by a lack of inflammation-reducing T cells. Specifically, they discovered that expression of the gene FoxP3 -- which helps control the production of anti-inflammatory T cells -- was an indicator of disease progression in 80 percent of the ALS patients they studied.

Low FoxP3 levels were likely in patients whose ALS progressed rapidly, while higher FoxP3 levels were associated with slower disease progression, according to the study published online recently in the EMBO Molecular Medicine Journal.

"This is the first demonstration that regulatory T cells may be slowing disease progression, since low FoxP3 indicates a rapidly progressing disease," lead author Jenny Henkel, an assistant professor of neurology, said in a hospital news release. "Levels of FoxP3 may now be used as a prognostic indicator of future disease progression and survival."

The link between inflammation and ALS progression is well established, and many genes associated with the disease have been identified, according to the news release.

"While inflammation exacerbates [worsens] disease in ALS patients, this inflammation is suppressed in some patients," Henkel said. "The data in our article suggest that regulatory T cells can suppress this inflammation."

She said researchers are closing in on specific targets for modifying the inflammation that drives ALS progression, and that they are also getting closer to developing new treatments for the disease.<
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Scientists train honey bees to stick out their tongues
2. NIH scientists reflect on gains in emerging infectious disease awareness, research and response
3. 2 UT Southwestern scientists honored as rising stars in Texas research
4. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
5. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
6. To make old skin cells act young again, boost their surroundings, U-M scientists show
7. Temple scientists target DNA repair to eradicate leukemia stem cells
8. Green scientists propose safety testing system for development of new chemicals
9. Scientists discover mechanism that could reduce obesity
10. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
11. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Gene That Shows Progression in ALS Patients
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... 26, 2014 The report “Nintedanib ... 2023” focuses on the current treatment landscape, unmet ... colorectal cancer market. Stivarga is a drug which ... rectal cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), ... of refractory CRC in the US, Europe, and ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
(Date:12/25/2014)... Miami, FL (PRWEB) December 25, 2014 When ... often find themselves in a frenzy to get rid of ... classroom. But families in Coral Gables now have the solution ... its second salon clinic location, Lice Troopers provides full spectrum ... in the Coral Gable area, including Sunset, Key Biscayne, Brickell, ...
(Date:12/25/2014)... -- Among early stage breast cancer patients who undergo ... percent will eventually develop leukemia as a result of ... comes from a review of more than 20,000 breast ... suggests that the risk for developing treatment-related leukemia, though ... "The frequency of bone marrow cancers such as ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... first time to date, research published in the October ... sought to determine the use of chemotherapy in ... encompassing all patient ages. Prior population-based studies have shown ... cancer patients receive chemotherapy treatment. These studies have previously ...
... Researchers from the Arkansas Epilepsy Program found treatment with ... compared with placebo, for patients with uncontrolled partial-onset seizures ... in Epilepsia , a journal published by Wiley-Blackwell ... Epilepsy affects up to 2% of the worldwide ...
... papillomavirus (HPV) DNA-based testing or visual inspection of the ... had a statistically significant reduction in high grade cervical ... according to a study published online Sept. 30 in ... In many developing countries, especially in ...
... of Health scientists could explain how Salmonella bacteria, a ... In a study published this week in the ... describe finding a reservoir of rapidly replicating Salmonella inside ... cells and are pushed from the epithelial layer by ...
... MEDFORD/SOMERVILLE, Mass.--Researchers from Tufts University School of Engineering and ... precursors to the potent anti-cancer compound Taxol in an ... The findings are significant steps on the way to ... to design new Taxol-like pharmaceuticals. The work ...
... Louisville School of Nursing has earned a $792,000 grant ... Health Resources and Services Administration to develop nursing informatics ... well as practicing nurses from University of Louisville Hospital. ... a tsunami of patient data in order to make ...
Cached Medicine News:Health News:New lung cancer research finds half of advanced lung cancer patients receive chemotherapy 2Health News:Adjunctive rufinamide reduces refractory partial-onset seizures 2Health News:HPV screen-and treat-intervention effective in cervical cancer prevention 2Health News:NIH scientists describe how salmonella bacteria spread in humans 2Health News:Researchers advance biosynthesis of potent anti-cancer drug Taxol 2Health News:UofL School of Nursing awarded grant to fund new informatics education project 2
(Date:12/24/2014)... 2014 Tianyin Pharmaceutical Co., Inc. (NYSE ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded ... that the Company achieved the Public Notice (Gong ... certificate of TPI,s Qionglai Facility (QLF) from the ... notice period is a significant procedure of GMP ...
(Date:12/22/2014)... 22, 2014 NxStage Medical, Inc. (NASDAQ: ... dialysis products, announced today that the U.S. Food ... One™ to perform hemodialysis overnight while the patient ... hemodialysis. NxStage,s® System One is the first and ... this indication. Home nocturnal hemodialysis ...
(Date:12/22/2014)...  ConvaTec, a privately-held medical products and technologies company, ... Chief Executive Officer of the company, effective December 22, ... .  "The Board of Directors of ConvaTec thanks Mr. ... past three years," said Magnus Lundberg , the ... that the company is well positioned for the future."  ...
Breaking Medicine Technology:TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... 4, 2011 Four-time NASCAR Cup Series champion Jeff ... track as he is for his philanthropic activities and ... support of the Alabama tornado relief effort through the ... shoes and clothing for babies and children affected by ...
... Rep. Ed Whitfield, R-Ky., has introduced a bill in ... education and certification standards in the Medicare program for ... imaging examinations and radiation therapy treatments. The ... Medical Imaging and Radiation Therapy bill (H.R. 2104) was ...
Cached Medicine Technology:Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims 2Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims 3Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims 4Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims 5Medical Imaging and Radiation Therapy Personnel Certification Bill Introduced in Congress 2Medical Imaging and Radiation Therapy Personnel Certification Bill Introduced in Congress 3
... with blade. Fiberoptic blades are designed ... allowing you to take advantage of ... from different fitting fiberoptic systems. FOCS™ ... cost effective alternative to expensive fiberoptic ...
... can be used with Portex® reusable or ... blades with long-lasting bronze fiber-optic bundles provide ... routine use., ,The laryngoscope blades are ... from infant to large adult, and in ...
... system. Providing an unobstructed view of the ... many types of intubations., ,A high ... patented Glidescope blade. Clear images are captured ... monitor screen. An LED light source mounted ...
... Tip Laryngoscopes are the most ... The articulating tip aids during ... improved view of epiglottis. Available ... styles. We guarantee your complete ...
Medicine Products: