Navigation Links
Scientists ID Gene That Shows Progression in ALS Patients
Date:12/12/2012

WEDNESDAY, Dec. 12 (HealthDay News) -- A gene that's an indicator of disease progression in most patients with amyotrophic lateral sclerosis (ALS) has been identified by researchers.

ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that slowly causes paralysis and death. It affects about five in 100,000 people and there is no known cure.

The researchers at the Methodist Hospital in Houston found that the debilitating symptoms of ALS appear to be increased by a lack of inflammation-reducing T cells. Specifically, they discovered that expression of the gene FoxP3 -- which helps control the production of anti-inflammatory T cells -- was an indicator of disease progression in 80 percent of the ALS patients they studied.

Low FoxP3 levels were likely in patients whose ALS progressed rapidly, while higher FoxP3 levels were associated with slower disease progression, according to the study published online recently in the EMBO Molecular Medicine Journal.

"This is the first demonstration that regulatory T cells may be slowing disease progression, since low FoxP3 indicates a rapidly progressing disease," lead author Jenny Henkel, an assistant professor of neurology, said in a hospital news release. "Levels of FoxP3 may now be used as a prognostic indicator of future disease progression and survival."

The link between inflammation and ALS progression is well established, and many genes associated with the disease have been identified, according to the news release.

"While inflammation exacerbates [worsens] disease in ALS patients, this inflammation is suppressed in some patients," Henkel said. "The data in our article suggest that regulatory T cells can suppress this inflammation."

She said researchers are closing in on specific targets for modifying the inflammation that drives ALS progression, and that they are also getting closer to developing new treatments for the disease.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about amyotrophic lateral sclerosis.

-- Robert Preidt

SOURCE: Methodist Hospital, news release, Dec. 7, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists train honey bees to stick out their tongues
2. NIH scientists reflect on gains in emerging infectious disease awareness, research and response
3. 2 UT Southwestern scientists honored as rising stars in Texas research
4. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
5. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
6. To make old skin cells act young again, boost their surroundings, U-M scientists show
7. Temple scientists target DNA repair to eradicate leukemia stem cells
8. Green scientists propose safety testing system for development of new chemicals
9. Scientists discover mechanism that could reduce obesity
10. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
11. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Gene That Shows Progression in ALS Patients
(Date:2/10/2016)... ... February 09, 2016 , ... Ross A. Clevens, MD, ... to welcome a new addition to their growing practice. Beginning this month, Teresa ... nurse practitioner performing cosmetic procedures including injectables, fillers and laser treatments. ...
(Date:2/9/2016)... ... February 09, 2016 , ... Steven Douglas Associates is a ... Florida Event, an upscale fundraiser held in South Florida. The Inaugural What’s Your Taste ... This year the event will be held in a new, more causal format at ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... production of its newest mobility device, the StandUp Walker. Made entirely in the ... in the last 50 years. , StandUp Walker’s novel patent-pending design offers 2-in-1 ...
(Date:2/9/2016)... Springs, FL (PRWEB) , ... February 09, 2016 ... ... leading innovative specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ ... for each prescription referral received at our specialty pharmacy. , “Since our ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Bon-Ton Stores, Inc. (NASDAQ: ... stores, announced it has raised $176,000 to benefit the Breast Cancer Research Foundation, ... at the University of Iowa, The Lynn Sage Cancer Research Foundation, and Masonic ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 9, 2016 On ... Administration (FDA) met with its Arthritis Advisory ... biosimilar of Johnson & Johnson,s Remicade and ... approved in the U.S. The Biologics Prescribers ... groups - Alliance for Patient Access, American ...
(Date:2/9/2016)... Calif. , Feb. 9, 2016 /PRNewswire/ - Nevro ... company that is providing innovative evidence-based solutions for the ... release financial results for the fourth quarter and full ... 29, 2016. Company management will host a conference call ... Time) on Monday, February 29, 2016. www.nevro.com ...
(Date:2/9/2016)... 9, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... today reported its fourth quarter and full year ... vivo therapeutic genome editing," said Edward Lanphier, ... finger nuclease (ZFN) technology leads the therapeutic genome ... competencies necessary to move our ground-breaking genome editing ...
Breaking Medicine Technology: