Navigation Links
Scientists ID Gene That Shows Progression in ALS Patients
Date:12/12/2012

WEDNESDAY, Dec. 12 (HealthDay News) -- A gene that's an indicator of disease progression in most patients with amyotrophic lateral sclerosis (ALS) has been identified by researchers.

ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that slowly causes paralysis and death. It affects about five in 100,000 people and there is no known cure.

The researchers at the Methodist Hospital in Houston found that the debilitating symptoms of ALS appear to be increased by a lack of inflammation-reducing T cells. Specifically, they discovered that expression of the gene FoxP3 -- which helps control the production of anti-inflammatory T cells -- was an indicator of disease progression in 80 percent of the ALS patients they studied.

Low FoxP3 levels were likely in patients whose ALS progressed rapidly, while higher FoxP3 levels were associated with slower disease progression, according to the study published online recently in the EMBO Molecular Medicine Journal.

"This is the first demonstration that regulatory T cells may be slowing disease progression, since low FoxP3 indicates a rapidly progressing disease," lead author Jenny Henkel, an assistant professor of neurology, said in a hospital news release. "Levels of FoxP3 may now be used as a prognostic indicator of future disease progression and survival."

The link between inflammation and ALS progression is well established, and many genes associated with the disease have been identified, according to the news release.

"While inflammation exacerbates [worsens] disease in ALS patients, this inflammation is suppressed in some patients," Henkel said. "The data in our article suggest that regulatory T cells can suppress this inflammation."

She said researchers are closing in on specific targets for modifying the inflammation that drives ALS progression, and that they are also getting closer to developing new treatments for the disease.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about amyotrophic lateral sclerosis.

-- Robert Preidt

SOURCE: Methodist Hospital, news release, Dec. 7, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists train honey bees to stick out their tongues
2. NIH scientists reflect on gains in emerging infectious disease awareness, research and response
3. 2 UT Southwestern scientists honored as rising stars in Texas research
4. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
5. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
6. To make old skin cells act young again, boost their surroundings, U-M scientists show
7. Temple scientists target DNA repair to eradicate leukemia stem cells
8. Green scientists propose safety testing system for development of new chemicals
9. Scientists discover mechanism that could reduce obesity
10. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
11. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Gene That Shows Progression in ALS Patients
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... been named one of Michigan’s 2017 Best and Brightest in Wellness® by Best ... in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  BioPharmX Corporation (NYSE MKT: ... that developed an innovative way to use nonlinear optical ... delivery of new drugs. ... Dermatology Conference will show how researchers from BioPharmX and ... Medical School used a suite of imaging techniques in ...
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
Breaking Medicine Technology: