Navigation Links
Scientists ID Gene That Shows Progression in ALS Patients

WEDNESDAY, Dec. 12 (HealthDay News) -- A gene that's an indicator of disease progression in most patients with amyotrophic lateral sclerosis (ALS) has been identified by researchers.

ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that slowly causes paralysis and death. It affects about five in 100,000 people and there is no known cure.

The researchers at the Methodist Hospital in Houston found that the debilitating symptoms of ALS appear to be increased by a lack of inflammation-reducing T cells. Specifically, they discovered that expression of the gene FoxP3 -- which helps control the production of anti-inflammatory T cells -- was an indicator of disease progression in 80 percent of the ALS patients they studied.

Low FoxP3 levels were likely in patients whose ALS progressed rapidly, while higher FoxP3 levels were associated with slower disease progression, according to the study published online recently in the EMBO Molecular Medicine Journal.

"This is the first demonstration that regulatory T cells may be slowing disease progression, since low FoxP3 indicates a rapidly progressing disease," lead author Jenny Henkel, an assistant professor of neurology, said in a hospital news release. "Levels of FoxP3 may now be used as a prognostic indicator of future disease progression and survival."

The link between inflammation and ALS progression is well established, and many genes associated with the disease have been identified, according to the news release.

"While inflammation exacerbates [worsens] disease in ALS patients, this inflammation is suppressed in some patients," Henkel said. "The data in our article suggest that regulatory T cells can suppress this inflammation."

She said researchers are closing in on specific targets for modifying the inflammation that drives ALS progression, and that they are also getting closer to developing new treatments for the disease.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about amyotrophic lateral sclerosis.

-- Robert Preidt

SOURCE: Methodist Hospital, news release, Dec. 7, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists train honey bees to stick out their tongues
2. NIH scientists reflect on gains in emerging infectious disease awareness, research and response
3. 2 UT Southwestern scientists honored as rising stars in Texas research
4. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
5. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
6. To make old skin cells act young again, boost their surroundings, U-M scientists show
7. Temple scientists target DNA repair to eradicate leukemia stem cells
8. Green scientists propose safety testing system for development of new chemicals
9. Scientists discover mechanism that could reduce obesity
10. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
11. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
Post Your Comments:
Related Image:
Scientists ID Gene That Shows Progression in ALS Patients
(Date:11/25/2015)... Ill. (PRWEB) , ... November 25, 2015 , ... ... and potentially more aggressive than those found on mammography, according to a study ... findings of additional cancers not seen on mammography may necessitate a change in ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... factory direct sauna parts and accessories. , Sauna accessories help improve the bather ... style and personality. From basic styles for the purist looking for simplicity in ...
(Date:11/25/2015)... , ... November 25, 2015 , ... According to an ... robot is being more and more widely heralded as a breakthrough for performing hernia ... method has over traditional laparoscopic surgery is that it can greatly reduce the pain ...
(Date:11/25/2015)... , ... November 25, 2015 , ... The McHenry County ... recent successful appellate decision obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. ... Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to court documents, ...
(Date:11/25/2015)... ... 25, 2015 , ... Brillianteen, McGaw YMCA’s student-produced musical show, ... 65th Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for this final ... has been a treasured tradition for numerous families in the Evanston community. Over ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... ATLANTA , Nov. 25, 2015 ... the first federal bellwether trial against Wright Medical ... relating to their Conserve metal-on-metal hip implant device, ... Christiansen.  Following a two week trial and three ... Conserve metal-on-metal hip device was defectively designed and ...
(Date:11/25/2015)... , Nov. 25, 2015  Trovagene, Inc. (NASDAQ: ... announced that Chief Executive Officer Antonius Schuh, Ph.D., is ... th Annual Piper Jaffray Healthcare Conference. ... New York Palace Hotel in New York ... p.m. EST. Mr. Schuh will be available for one-on-one ...
(Date:11/25/2015)... --> --> ... was valued at $11,171.1 million in 2014, and it ... during 2015 - 2022. The global market is growing, ... diabetes. In addition, the increase in obese population and ... the growth of the market. Furthermore, technological advancements in ...
Breaking Medicine Technology: