Navigation Links
Scientists ID Gene Regulating Blood Glucose Levels
Date:6/7/2008

Copies of variant don't boost type 2 diabetes risk but could suggest its causes

FRIDAY, June 6 (HealthDay News) -- Researchers who've identified a gene that regulates glucose levels but does not increase the risk of type 2 diabetes say their finding may help improve understanding of the underlying causes of diabetes.

"Elevations of blood glucose are diagnostic of diabetes. This finding demonstrates there are gene variants that are important in day-to-day regulation of glucose, but they do not appear to play a significant role in disease risk," co-senior author Richard M. Watanabe, an associate professor of preventive medicine and physiology & biophysics at the Keck School of Medicine at the University of Southern California, said in a prepared statement.

"The identification of these variants increases our basic knowledge about regulation of glucose and may also be useful in future genetic studies to help discriminate between genetic variants that do or do not contribute to disease susceptibility," Watanabe said.

The researchers analyzed genetic information from thousands of people and concluded a gene on chromosome 2 that encodes for the enzyme glucose-6-phosphatase catalytic 2 (G6PC2) is associated with fasting glucose levels.

"G6PC2 is primarily expressed in the beta cells of the pancreas and is responsible for converting glucose-6-phosphate back to glucose. Genetic variation of G6PC2 may be responsible for reducing insulin secretion and causing the glucose concentration to increase," Watanabe said.

With each additional copy of the higher frequency variant of the gene, glucose concentrations increased. Chronically elevated glucose levels may be a precursor to type 2 diabetes, Watanabe noted.

The study is published in the July issue of The Journal of Clinical Investigation.

"Genetics is identifying a whole new set of genes, proteins and pathways that are related to diabetes and blood sugar control. Our next challenge is to figure out how these genes work," study co-author Dr. Thomas A. Buchanan, professor of endocrinology at Keck, said in a prepared statement.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Robert Preidt



SOURCE: University of Southern California Health Sciences, news release, June 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 27, 2016 , ... Aimed at nurses and employees in ... courtesy of leaders in the nursing and health care industry. It also provides ... and associations—namely Jones & Bartlett Learning. , Jones & Bartlett Learning is adding ...
(Date:5/26/2016)... ... 2016 , ... Despite last week’s media reports hinting at a June rate ... until March 2017 for an interest rate increase, according to Rajeev Dhawan of the ... “The Federal Open Market Committee (FOMC) dot charts are of interest to the press ...
(Date:5/26/2016)... St. Louis, Missouri (PRWEB) , ... May 26, ... ... optimal cost, quality and clinical outcomes, hosted members and suppliers for its inaugural ... with a focus on their mission of elevating the operational health of America’s ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Woodlands at ... offering a new model of care for living and healing, celebrated its grand opening, ... Life in a Real Home provided by Empowered Staff. , “This is an incredibly ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... solutions for drugs, biologics, consumer health and global clinical supply services, today announced ... to support the company’s continued investment and strategic growth plans in the Asia ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... NASHVILLE, Tenn. , May 26, 2016 ... provider of software and analytics, network solutions ... healthcare, today announced it entered into a ... leading provider of outpatient software solutions and ... surgery centers, specialty hospitals and rehabilitation clinics ...
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) today ... co-development agreement with Therawis Diagnostics GmbH to develop and commercialize ... develop and market PITX2 as a marker to predict effectiveness ... cancer patients. "We are pleased to partner with ...
(Date:5/25/2016)... Va. , May 25, 2016  Granger Diagnostics ... sequencing test for wounds and infections. This test ... parasites, and select viruses. The test requires only ... David G. Bostwick , ... testing to facilitate wound healing: "We are excited ...
Breaking Medicine Technology: