Navigation Links
Scientists ID Gene Behind Early Onset Puberty
Date:6/5/2013

WEDNESDAY, June 5 (HealthDay News) -- Scientists say they've identified a gene mutation behind a condition that causes children to undergo puberty before the age of 9.

The condition, known as central precocious puberty, appears to be inherited via a gene passed along by fathers, say researchers reporting online June 5 in the New England Journal of Medicine.

Besides helping children with central precocious puberty, "these findings will open the door for a new understanding of what controls the timing of puberty" generally, co-senior study author Dr. Ursula Kaiser, chief of the endocrinology, diabetes and hypertension division at Brigham and Women's Hospital in Boston, said in a hospital news release.

According to the authors, the mutation leads to the start of puberty before age 8 in girls and before age 9 in boys. That's earlier than the typical onset of puberty, which begins in girls between ages 8 and 13 and in boys between ages 9 and 14.

The study included genetic analyses of 40 people from 15 families with a history of early puberty. In five of the 15 families, the researchers discovered four mutations in the MKRN3 gene. A mutation in the MKRN3 gene can lead to premature activation of reproductive hormones and trigger early puberty, the study authors explained in the news release.

All of the people with the MKRN3 mutations inherited them from their fathers.

One expert who reviewed the research said the finding should be a great advance for children with central precocious puberty.

Testing children for the MKRN3 mutation "may help in the diagnosis, preventing the use of extensive testing and procedures such as MRI of the head," explained Dr. Patricia Vuguin, pediatric endocrinologist at Steven & Alexandra Cohen Children's Medical Center of New York, in New Hyde Park, N.Y.

She said better diagnostic tests would help spot patients at risk for early puberty and problems that often accompany it, such as short stature, psychological issues and other possible health issues. More generally, "the diagnosis will also help understand the role of this gene and other associated genes on how and when kids go into puberty, an area that is currently not clear," Vuguin said.

The findings will also be presented June 17 at the Endocrine Society's annual meeting.

More information

The Nemours Foundation has more about early puberty.

-- Robert Preidt

SOURCES: Patricia Vuguin, M.D., M.Sc., pediatric endocrinologist, Steven & Alexandra Cohen Children's Medical Center of New York, New Hyde Park, N.Y.; Brigham and Women's Hospital, news release, June 5, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Gene Behind Early Onset Puberty
(Date:3/29/2017)... ... , ... Hamlin Dental Group, multi-location dental office in North Hollywood , ... are safe and effective options, and can be used alone or in conjunction with ... of care. , Dr. Hamid Reza of Hamlin Dental Group offers other treatments as ...
(Date:3/29/2017)... ... ... has helped over 1.5 million SharePoint users learn the content management system faster and ... for SharePoint was at the farm level. Enterprises using SharePoint Online in Office 365 ... recently released a modified version of the Help System, VisualSP for Site Collections, which ...
(Date:3/28/2017)... ... March 28, 2017 , ... Greenfield Advisors is expanding ... extensive knowledge of appraisals, property values, ad valorem taxation, and government policy to ... for more than 40 years. , “Ruel is a great addition to the ...
(Date:3/28/2017)... Seattle, WA (PRWEB) , ... March 28, 2017 ... ... reach a 22% share of all holidays (IBT World Travel Trends Report). As ... physically challenging, include a range in temperatures, and prolonged sun exposure. In response, ...
(Date:3/28/2017)... Wallingford, CT (PRWEB) , ... March 28, 2017 ... ... hemostatic devices, announces today that the University of Pittsburgh Medical Center (UPMC) will ... Central and Western Pennsylvania. , The program, developed in association with efforts by ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TORONTO , March 28, 2017 /PRNewswire/ - ... service medical device development firm, announced today that it ... Toronto -based medical device industrial design and productization ... companies throughout North America with ... device talent spanning the design, engineering, regulatory, and manufacturing ...
(Date:3/28/2017)... and TEL AVIV, Israel , March 28, 2017 ... Israel . This new business entity, Emosis Ltd, ... dedicated to research and development of novel assays complementing the mother ... when relevant, locally support commercialization and sales development of Emosis kits. ... This strategic move ...
(Date:3/28/2017)... Mass. , March 28, 2017 ... company developing innovative therapeutics that address significant unmet ... a patent from the Japan Patent Office (JPO) ... connective tissue growth factor (CTGF) for the treatment ... limited to skin fibrosis and proliferative retinopathy (Japanese ...
Breaking Medicine Technology: