Navigation Links
Scientists ID Enzyme That Allows Dysentery Amoeba to Hide
Date:6/19/2008

Finding could lead to more effective treatments for diarrhea worldwide, study says

THURSDAY, June 19 (HealthDay News) U.S. researchers say they've identified an enzyme that may help dysentery-causing amoeba evade the immune system.

The finding may help lead to new ways to fight dysentery, a form of diarrhea that affects about 500 million people worldwide each year and is a serious health threat in many regions.

"This is the first enzyme to be identified that looks like it could mediate immune system evasion," Sin Urban, an assistant professor of molecular biology and genetics at Johns Hopkins University, Baltimore, said in a prepared statement.

Urban and colleagues found the EhROM1 enzyme in the dysentery-causing amoeba Entamoeba histolytica.

The study was published in the June 15 issue of the journal Genes & Development.

The EhROM1 enzyme is part of an ancient group of enzymes known as rhomboid enzymes. In most animals, these enzymes play a role in cell-to-cell communication. But a few years ago, Urban found that malaria parasites use rhomboid enzymes to invade host cells.

This led him to look at the DNA of other disease-causing organisms to see if any of them also had genes that encode rhomboid enzymes. That led to the discovery of EhROM1 in Entamoeba histolytica. More research is needed to determine exactly how it helps this amoeba evade detection by the immune system.

The EhROM1 enzyme is similar to those found in malaria parasites, which suggests that a drug that targets EhROM1 in order to treat dysentery might also prove effective against malaria, Urban said.

More information

The U.S. Centers for Disease Control and Prevention has more about chronic diarrhea.



-- Robert Preidt



SOURCE: Johns Hopkins Medicine, news release, June 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
2. UF scientists to work with German firm in prostate cancer treatment research
3. Scientists from Granada drastically reduce the wait time for new teeth implant
4. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
5. Scientists Discover Protein Involved in Fat Production
6. Twenty of Americas Most Promising Scientists Selected as 2008 Pew Scholars in the Biomedical Sciences
7. QBI neuroscientists make Alzheimers disease advance
8. EPA scientists recognized with prestigious honor
9. 2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications
10. Scientists ID Brain Pathway That Stops Seizures
11. Scientists ID Gene Regulating Blood Glucose Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
(Date:9/19/2017)... HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that ... developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and ...
Breaking Medicine Technology: