Navigation Links
Scientists ID Enzyme That Allows Dysentery Amoeba to Hide
Date:6/19/2008

Finding could lead to more effective treatments for diarrhea worldwide, study says

THURSDAY, June 19 (HealthDay News) U.S. researchers say they've identified an enzyme that may help dysentery-causing amoeba evade the immune system.

The finding may help lead to new ways to fight dysentery, a form of diarrhea that affects about 500 million people worldwide each year and is a serious health threat in many regions.

"This is the first enzyme to be identified that looks like it could mediate immune system evasion," Sin Urban, an assistant professor of molecular biology and genetics at Johns Hopkins University, Baltimore, said in a prepared statement.

Urban and colleagues found the EhROM1 enzyme in the dysentery-causing amoeba Entamoeba histolytica.

The study was published in the June 15 issue of the journal Genes & Development.

The EhROM1 enzyme is part of an ancient group of enzymes known as rhomboid enzymes. In most animals, these enzymes play a role in cell-to-cell communication. But a few years ago, Urban found that malaria parasites use rhomboid enzymes to invade host cells.

This led him to look at the DNA of other disease-causing organisms to see if any of them also had genes that encode rhomboid enzymes. That led to the discovery of EhROM1 in Entamoeba histolytica. More research is needed to determine exactly how it helps this amoeba evade detection by the immune system.

The EhROM1 enzyme is similar to those found in malaria parasites, which suggests that a drug that targets EhROM1 in order to treat dysentery might also prove effective against malaria, Urban said.

More information

The U.S. Centers for Disease Control and Prevention has more about chronic diarrhea.



-- Robert Preidt



SOURCE: Johns Hopkins Medicine, news release, June 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
2. UF scientists to work with German firm in prostate cancer treatment research
3. Scientists from Granada drastically reduce the wait time for new teeth implant
4. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
5. Scientists Discover Protein Involved in Fat Production
6. Twenty of Americas Most Promising Scientists Selected as 2008 Pew Scholars in the Biomedical Sciences
7. QBI neuroscientists make Alzheimers disease advance
8. EPA scientists recognized with prestigious honor
9. 2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications
10. Scientists ID Brain Pathway That Stops Seizures
11. Scientists ID Gene Regulating Blood Glucose Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... , ... May 26, 2016 , ... ... Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, ... public. , Dr. Maisel, founder of Retina Group of New York , ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... In an effort to provide hair restoration ... to both Snapchat users and those who do not use the app. Dr. Mohebi, the ... new page, Dr. Mohebi Live . , Dr. Mohebi says, “The positive response ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership ... solutions, today announced the organization has earned its ISO 13485 certification, indicating the ... compliant with all rules and policies associated with ISO quality standard 13485. ...
(Date:5/26/2016)... ... ... The Lung Institute has partnered with the Gulfcoast North Area ... at their clinic in downtown Tampa. The class is complimentary for the public. Register ... a free downloadable 4 Week Smoking Cessation Guide for those who are ...
(Date:5/26/2016)... ... May 26, 2016 , ... Nike Yoga Camps ... from daily practices, arts & crafts, discussions, and games all geared towards enhancing ... Evans have combined backgrounds in kids’ yoga, collegiate sport yoga instruction, and global ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... WASHINGTON , May 26, 2016 ... Microspheres, Associated With Both Cost Savings and ... BTG plc (LSE: BTG), an international specialist healthcare ... data at the 21st Annual Meeting of ISPOR ... that treatment of hepatocellular carcinoma (HCC) using yttrium-90 ...
(Date:5/25/2016)... und GERMANTOWN, Maryland , May ... mit Therawis bedient dringenden ... QIAGEN N.V. (NASDAQ: QGEN ... eine Lizenz- und Entwicklungsvereinbarung mit Therawis Diagnostics GmbH ... Onkologie eingegangen zu sein. Ein erstes Projekt wird ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
Breaking Medicine Technology: