Navigation Links
Scientists ID Enzyme That Allows Dysentery Amoeba to Hide
Date:6/19/2008

Finding could lead to more effective treatments for diarrhea worldwide, study says

THURSDAY, June 19 (HealthDay News) U.S. researchers say they've identified an enzyme that may help dysentery-causing amoeba evade the immune system.

The finding may help lead to new ways to fight dysentery, a form of diarrhea that affects about 500 million people worldwide each year and is a serious health threat in many regions.

"This is the first enzyme to be identified that looks like it could mediate immune system evasion," Sin Urban, an assistant professor of molecular biology and genetics at Johns Hopkins University, Baltimore, said in a prepared statement.

Urban and colleagues found the EhROM1 enzyme in the dysentery-causing amoeba Entamoeba histolytica.

The study was published in the June 15 issue of the journal Genes & Development.

The EhROM1 enzyme is part of an ancient group of enzymes known as rhomboid enzymes. In most animals, these enzymes play a role in cell-to-cell communication. But a few years ago, Urban found that malaria parasites use rhomboid enzymes to invade host cells.

This led him to look at the DNA of other disease-causing organisms to see if any of them also had genes that encode rhomboid enzymes. That led to the discovery of EhROM1 in Entamoeba histolytica. More research is needed to determine exactly how it helps this amoeba evade detection by the immune system.

The EhROM1 enzyme is similar to those found in malaria parasites, which suggests that a drug that targets EhROM1 in order to treat dysentery might also prove effective against malaria, Urban said.

More information

The U.S. Centers for Disease Control and Prevention has more about chronic diarrhea.



-- Robert Preidt



SOURCE: Johns Hopkins Medicine, news release, June 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
2. UF scientists to work with German firm in prostate cancer treatment research
3. Scientists from Granada drastically reduce the wait time for new teeth implant
4. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
5. Scientists Discover Protein Involved in Fat Production
6. Twenty of Americas Most Promising Scientists Selected as 2008 Pew Scholars in the Biomedical Sciences
7. QBI neuroscientists make Alzheimers disease advance
8. EPA scientists recognized with prestigious honor
9. 2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications
10. Scientists ID Brain Pathway That Stops Seizures
11. Scientists ID Gene Regulating Blood Glucose Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... San Diego, CA (PRWEB) , ... March 28, 2017 , ... ... and turtlenecks from the daily wardrobe. However, for those self-conscious about a double chin, ... believe they have the ideal solution. , “For most people, a double chin ...
(Date:3/28/2017)... ... March 28, 2017 , ... Neurotechnology , ... biometric time and attendance tracking products: the new NCheck Cloud Bio Attendance cloud-based ... Attendance uses biometric face recognition to enable users to check in and out ...
(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin ... one of few medical professionals in the country to sit on the 2017 National ... Aesthetics, in just 2 years Dr. Harper helped propel the clinic from a small ...
(Date:3/28/2017)... Atlantic City, NJ (PRWEB) , ... March 28, ... ... annual American Camp Association’s Tri-State Camp Conference in Atlantic City March 13-16, was ... partners, and their team of professional staff discussed strategies for preventing outbreaks among ...
(Date:3/28/2017)... St. Louis, MO (PRWEB) , ... March 28, ... ... high levels of job satisfaction in their profession as their value increases in ... a company that provides resources such as job boards, career fairs, and candidate ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... United Kingdom and  BOSTON , March 28, ... Linguamatics today announced a partnership with ... The agreement allows pharmaceutical companies to extract key ... I2E text mining technology. The ... of the top 20 global pharmaceutical companies. The ...
(Date:3/28/2017)... , March 28, 2017  AcelRx Pharmaceuticals, Inc. ... the development and commercialization of innovative therapies for ... the European Medicines Agency (EMA) has notified the ... mcg) Marketing Authorisation Application (MAA) has passed validation, ... is underway. The MAA for ARX-04 (known as ...
(Date:3/28/2017)... 28, 2017 The global ... 8.0 billion by 2025, according to a new study ... infectious diseases and cancer is expected to upsurge the ... over the coming years. In addition, higher number of ... allogenic stem cell therapy, due to adverse effects caused ...
Breaking Medicine Technology: