Navigation Links
Scientists ID Enzyme That Allows Dysentery Amoeba to Hide
Date:6/19/2008

Finding could lead to more effective treatments for diarrhea worldwide, study says

THURSDAY, June 19 (HealthDay News) U.S. researchers say they've identified an enzyme that may help dysentery-causing amoeba evade the immune system.

The finding may help lead to new ways to fight dysentery, a form of diarrhea that affects about 500 million people worldwide each year and is a serious health threat in many regions.

"This is the first enzyme to be identified that looks like it could mediate immune system evasion," Sin Urban, an assistant professor of molecular biology and genetics at Johns Hopkins University, Baltimore, said in a prepared statement.

Urban and colleagues found the EhROM1 enzyme in the dysentery-causing amoeba Entamoeba histolytica.

The study was published in the June 15 issue of the journal Genes & Development.

The EhROM1 enzyme is part of an ancient group of enzymes known as rhomboid enzymes. In most animals, these enzymes play a role in cell-to-cell communication. But a few years ago, Urban found that malaria parasites use rhomboid enzymes to invade host cells.

This led him to look at the DNA of other disease-causing organisms to see if any of them also had genes that encode rhomboid enzymes. That led to the discovery of EhROM1 in Entamoeba histolytica. More research is needed to determine exactly how it helps this amoeba evade detection by the immune system.

The EhROM1 enzyme is similar to those found in malaria parasites, which suggests that a drug that targets EhROM1 in order to treat dysentery might also prove effective against malaria, Urban said.

More information

The U.S. Centers for Disease Control and Prevention has more about chronic diarrhea.



-- Robert Preidt



SOURCE: Johns Hopkins Medicine, news release, June 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
2. UF scientists to work with German firm in prostate cancer treatment research
3. Scientists from Granada drastically reduce the wait time for new teeth implant
4. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
5. Scientists Discover Protein Involved in Fat Production
6. Twenty of Americas Most Promising Scientists Selected as 2008 Pew Scholars in the Biomedical Sciences
7. QBI neuroscientists make Alzheimers disease advance
8. EPA scientists recognized with prestigious honor
9. 2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications
10. Scientists ID Brain Pathway That Stops Seizures
11. Scientists ID Gene Regulating Blood Glucose Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Multiple award ... been family-owned and operated for over 35 years. Maintaining core values of exceptional customer ... their success and made them a leading name in San Diego plumbing, and other ...
(Date:5/6/2016)... ... May 06, 2016 , ... Few events in healthcare changed ... for its cost despite its potential to wipe out a silent killer, hepatitis ... a class called direct-acting antivirals (DAAs)—have created fallout in the courts and state ...
(Date:5/6/2016)... ... May 06, 2016 , ... This Mother’s Day kicks off ... The 17th annual National Women’s Health Week takes place May 8-May 14. ... are combining forces to empower women to make their health a top priority. Women ...
(Date:5/6/2016)... ... 06, 2016 , ... “ Crossing Over: Affirmations of Faith in the Midst ... have allowed those holding vigil to glimpse into the supernatural as their lives ended. ... readers spiritually and practically gain insight into providing care to terminal patients. , ...
(Date:5/5/2016)... ... 2016 , ... TransWipe Volume 3 is a set of 30 professional transition ... preset between two video clips to instantly add a unique transition to any Final ... color and orientation options. TransWipe Volume 3 is a Final Cut Pro X exclusive ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... May 5, 2016  Endo International plc (NASDAQ: ... that Brian Lortie , President, U.S. Branded ... position upon the appointment of a successor. Mr. ... U.S. Pharmaceuticals business with responsibility for all strategic, ... strategy and portfolio development, commercial operations, managed markets, ...
(Date:5/5/2016)... First quarter 2016 adjusted diluted earnings per share (EPS) of ... First quarter reported diluted (GAAP) loss per share from continuing ... financial guidance; now expects 2016 revenues to range from $3.87 ... per share to range from $4.50 to $4.80 ... facility restructuring , Company expands Board capabilities, ...
(Date:5/5/2016)... , May 5, 2016  Diagnostic imaging ... decade due to concerns that these tests cause health ... approach to imaging, as well as the adoption ... era of medical peripherals that help health care providers cut ... Ampronix  advanced medical imaging is a renowned authorized reseller ...
Breaking Medicine Technology: