Navigation Links
Scientists ID Enzyme Causing Brain Cell Death
Date:12/10/2008

Findings could offer new therapies for neurodegenerative diseases

WEDNESDAY, Dec. 10 (HealthDay News) -- An enzyme believed to play a role in the death of neurons in the brains of patients with Alzheimer's and other neurodegenerative diseases has been identified by U.S. researchers.

The finding could help in the development of new drugs to treat these debilitating conditions.

The scientists focused on an enzyme called HDAC1, which configures chromatin, the structural component of chromosomes. Tests in mice found that when HDAC1 is blocked, some neurons start to replicate their DNA as if they were about to divide. This isn't a natural cycle for neurons and causes them to die. But increased levels of HDAC1 prevent this process and protect neurons.

The finding that HDAC1 is a molecular link between aberrant neuron cell-cycle activity and DNA damage suggests that the enzyme may be a potential target for drugs to treat diseases and conditions that involve neuronal death, the researchers said.

"Our findings provide insight into how neurons die in neurodegenerative diseases and offer a new therapeutic strategy for countering neuronal death," study leader Li-Huei Tsai, a professor of neuroscience at Massachusetts Institute of Technology, said in a school news release.

The study was published in the Dec. 11 issue of Neuron.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Dec. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Enzyme Causing Brain Cell Death 
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with ... will raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and ... is in a low-income area and has more than 60 2nd and 3rd graders ...
(Date:2/12/2016)... ... ... Vail knee specialist Robert LaPrade, MD, PhD was named one ... consists of physicians establishing, leading and partnering with ambulatory surgery centers across the United ... Center, also known as an ASC, is a modern health care facility focused on ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a full ... of the latest charity campaign in their community enrichment program. Art Expression utilizes ... worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Miami Dental ... implants to their Miami dental office. Beginning in January, Miami Dental Specialists will ... Miami Dental Specialists are the first office to be chosen by the dental implant ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12 2016  OMS Supply, a large ... medical practitioners, announced today the recent launching of their ... a variety of features that enhance the user experience ... supplies. --> --> ... fairly new company that started in early 2016, they ...
(Date:2/12/2016)... Maharashtra, February 12, 2016 ... report titled Chronic Inflammation Global Clinical Trials Review, ... of the global clinical trials landscape along with ... by Region, Country (G7 & E7), Trial Status, ... and reviews top companies involved and enlists all ...
(Date:2/11/2016)... IRVINE, Calif., Feb. 11, 2016 PRO-DEX, INC. (NasdaqCM: ... quarter ended December 31, 2015. The Company also filed its ... fiscal year 2016 with the Securities and Exchange Commission today. ... December 31, 2015 --> --> ... 2015 increased $2.6 million, or 95%, to $5.4 million from ...
Breaking Medicine Technology: