Navigation Links
Scientists ID Enzyme Causing Brain Cell Death
Date:12/10/2008

Findings could offer new therapies for neurodegenerative diseases

WEDNESDAY, Dec. 10 (HealthDay News) -- An enzyme believed to play a role in the death of neurons in the brains of patients with Alzheimer's and other neurodegenerative diseases has been identified by U.S. researchers.

The finding could help in the development of new drugs to treat these debilitating conditions.

The scientists focused on an enzyme called HDAC1, which configures chromatin, the structural component of chromosomes. Tests in mice found that when HDAC1 is blocked, some neurons start to replicate their DNA as if they were about to divide. This isn't a natural cycle for neurons and causes them to die. But increased levels of HDAC1 prevent this process and protect neurons.

The finding that HDAC1 is a molecular link between aberrant neuron cell-cycle activity and DNA damage suggests that the enzyme may be a potential target for drugs to treat diseases and conditions that involve neuronal death, the researchers said.

"Our findings provide insight into how neurons die in neurodegenerative diseases and offer a new therapeutic strategy for countering neuronal death," study leader Li-Huei Tsai, a professor of neuroscience at Massachusetts Institute of Technology, said in a school news release.

The study was published in the Dec. 11 issue of Neuron.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Dec. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Enzyme Causing Brain Cell Death 
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based facial plastic ... med-spa with the addition of new Silk Peel skin ... and services. , “Silk Peel is a procedure that ... “As a result it can address issues like acne ... or blemishes.” , Similar to microdermabrasion, Silk Peel ...
(Date:12/24/2014)... Yunx.co.uk, a hot style dress supplier that offers all ... unveils 65 new bridesmaid dresses and announces ... to 80% off. , Yunx.co.uk’s dresses are very popular ... looks and delicate craftsmanship. These new bridesmaid dresses are ... and offering high-quality women’s dresses with fast delivery to ...
(Date:12/24/2014)... a famous bamboo flooring company offering bamboo flooring products ... its multiple layer bamboo panel board collection , and ... Bamboo panel is the product made from 100 percent ... features high quality selective bamboo and eco-friendly adhesives that ... consists of multiple layers of bamboo. , According to ...
(Date:12/24/2014)... infection does not contribute to mental decline in people with ... made it possible for people with HIV to survive much ... and other types of mental impairment as they age, the ... other viruses -- a common problem in people with HIV ... has been the hepatitis C virus, which infects about one ...
(Date:12/24/2014)... (HealthDay News) -- Researchers say they have used human ... eggs and sperm. While this had already been ... time that these types of cells -- called primordial ... stem cells, according to the team at the University ... germ cells is one of the earliest events during ...
Breaking Medicine News(10 mins):Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2
... protective effect , SUNDAY, April 18 (HealthDay News) -- ... seem to have a reduced risk of developing breast ... the study, which is to be presented Sunday at ... Washington, D.C., did not separate out which specific vitamins ...
... from a sentinel lymph node removed during surgery is a ... false negatives, which means the node, when analyzed under a ... occur in the patient. The sentinel node is the first ... Now, researchers from Georgetown Lombardi Comprehensive Center say that they ...
... ... has successfully completed deployment of CellTrak workflow automation and visit compliance solutions. The ... , ... April 18, 2010 -- ABC Hospice, Inc, a premier hospice provider in North East ...
... ... , ... (PRWEB) April 18, 2010 -- Allegheny Medical Integrated Health Services ( http://www.alleghenymedical.com/ ), one ... professionals whose mission is to build better health for every aspect of an individual,s ...
... life than in past generations, study finds , FRIDAY, April ... an earlier age and failing to lose the extra pounds ... expectancy will be worse than previously estimated. , The ... 1966 and 1985 became obese -- a step above merely ...
... ... Orthopedics is donating 300 seedlings for Westminster’s Arbor Day and Earth Day Celebration Saturday, April ... Golden, CO (PRWEB) ... with the City of Westminster to celebrate Earth Day and Arbor Day April 17. As ...
Cached Medicine News:Health News:Supplements Might Reduce Breast Cancer Risk 2Health News:Supplements Might Reduce Breast Cancer Risk 3Health News:Routine breast cancer biopsy might predict lymph node cancer spread 2Health News:CellTrak Increases Employee Productivity and Efficiencies at ABC Hospice, Inc. 2Health News:CellTrak Increases Employee Productivity and Efficiencies at ABC Hospice, Inc. 3Health News:Allegheny Medical's Occupational Health Services Helps Employers Build a Healthier Workforce 2Health News:Allegheny Medical's Occupational Health Services Helps Employers Build a Healthier Workforce 3Health News:Obesity Epidemic May Cut Life Spans of Young Adults 2Health News:Panorama Orthopedics and the City of Westminster Join Forces to Improve the Environment through Tree Giveaway 2
(Date:12/22/2014)... 22, 2014  ConvaTec, a privately-held medical products and ... appointed Interim Chief Executive Officer of the company, effective ... Ken Berger .  "The Board of Directors of ConvaTec ... over the past three years," said Magnus Lundberg ... are confident that the company is well positioned for ...
(Date:12/22/2014)... 22, 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation (NASDAQ: ... discovering, developing and commercializing innovative therapies addressing major ... the following open letter to shareholders from President ... Sc. Dear RXi Shareholders, ... inaccurate statements posted on certain social media sites ...
(Date:12/22/2014)... , Dec. 22, 2014  Pfenex Inc. (NYSE ... recombinant anthrax vaccine, has been filed and is now ... provided by the Department of Health and Human Services ... (BARDA). "We are extremely pleased to have ... Px563L.  This represents a significant milestone in our company,s ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 3
... September 30 Gamida Cell announced,today the publication of ... widely known as "StemEx", as a therapy for blood ... ex vivo expanded,umbilical cord blood cell graft for allogeneic ... Petropoulos, will be published in the,November 2009 issue of ...
... 30 GenVec, Inc. (Nasdaq: GNVC ) announced today ... and Research (SBIR) grant from the National Cancer Institute (NCI) ... research of a new approach to treating metastatic cancer. Under ... hypothesis that the delivery of a specific gene will stimulate ...
Cached Medicine Technology:Article Published in Expert Opinion on Biological Therapy Evaluates StemEx(R) (carlecortemcel-l) for Leukemia and Lymphoma 2Article Published in Expert Opinion on Biological Therapy Evaluates StemEx(R) (carlecortemcel-l) for Leukemia and Lymphoma 3GenVec Receives National Cancer Institute Grant to Expand Cancer Program 2
... This Sarmiento style Patella-Tendon-Bearing brace is designed ... the tibia and fibula. The tibial crest ... intra medullary nailing and removal of internal ... movement of joints above and below the ...
Designed as an excellent form of primary suspension...
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... This lightweight orthosis is designed to ... joint while allowing unobstructed motion of ... more custom fit the splint may ... formed using a heat gun. One ...
Medicine Products: