Navigation Links
Scientists ID Brain Pathway That Stops Seizures
Date:6/8/2008

Mouse study finds gene affects acids that regulate severity of convulsions

SUNDAY, June 8 (HealthDay News) -- A brain pathway that stops seizures has been found by Iowa researchers.

Applying modern genetics and molecular biology to clinical observations made more than 80 years ago, a team from the University of Iowa and the Veterans Affairs Iowa City Health Care System found that increased acid (pH) activates an ion channel in the brain that shuts down seizure activity. The findings were expected to be published online June 8 in Nature Neuroscience.

"Although this work provides insight into how seizures normally stop and might help us learn more about how to terminate those seizures that don't stop, it will take more work to turn the finding into a new therapeutic approach," senior study author Dr. John Wemmie, an assistant professor of psychiatry in the University of Iowa's Roy J. and Lucille A. Carver College of Medicine, said in a prepared statement. "We will be working with colleagues in neurology and neurosurgery to try and translate the findings to treatments."

Clinical experiments from the first half of the 20th century show breathing carbon dioxide, which creates more acid in brain tissue, helps stop epileptic seizures while the seizures themselves lower brain pH. The modern discovery of an acid-activated ion channel (ASIC1a) in the brain helped the team piece the puzzle together.

"We found that ASIC1a does not seem to play a role in how a seizure starts, but as the seizure continues, and the pH is reduced, ASIC1a appears to play a role in stopping additional seizure activity," study co-lead author Adam Ziemann, a student in the Medical Scientist Training Program at the university, said in a prepared statement.

Researchers found that seizures are more severe and longer in mice lacking the ASIC1a gene than those with the gene. Also, chemically blocking ASIC1a causes the se
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... In a July 9th article in the Money ... Lotus Blossom Consulting LLC , was quoted in a Family ... Cut the High Cost of Infertility . Her advice began ... maximize your chance of success from the first attempt.” The ... “I am always happy to talk with the media ...
(Date:7/24/2014)... its 2014 Power of A Award winners, including two ... , The ASA Global Humanitarian Outreach (GHO) program ... the top honors from ASAE. GHO was honored for ... on the global anesthesia crisis and supporting low income ... honored with a Power of A Silver Award for ...
(Date:7/24/2014)... Kathleen Doheny HealthDay Reporter ... children often don,t view their kids as unhealthy or recognize ... a new study. The children of the families surveyed ... the Hasbro Children,s Hospital in Providence, R.I. "A third ... study researcher Dr. Kyung Rhee, now an assistant professor of ...
(Date:7/24/2014)... Pools and beaches are the place to be ... especially for small children, so Amica Insurance is ... the Centers for Disease Control and Prevention, children between the ... water-related injuries and deaths. It’s important to know the best ... is offering the following tips from the American Red Cross:, ...
(Date:7/24/2014)... treatment of overweight and obese preschoolers works better when ... only the child is targeted, according to research published ... the University at Buffalo and Women and Children,s Hospital ... or obese and had one parent who participated in ... to body mass index (BMI) measurements, calculated based on ...
Breaking Medicine News(10 mins):Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3Health News:Parents of Obese Kids Often View Them as Healthy 2Health News:Parents of Obese Kids Often View Them as Healthy 3Health News:Keep Kids Safe in the Water with 5 Tips from Amica 2Health News:Overweight and obese preschoolers lose more weight when parent is also treated 2Health News:Overweight and obese preschoolers lose more weight when parent is also treated 3
... Formulary, the leading provider of access to and ... to customized formulary data and co-pay reports. Fingertip ... now offers subscribers the ability to save report ... offers eleven comprehensive reports that provide real-time current ...
... opens new office outside of Seattle, expands workforceTAMPA, ... Targeted Population Health Management company focused on the ... expanding its workforce to include more than 40 ... Lynnwood, Wash. The new site is the Company,s ...
... Full Year Highlights:- Fourth quarter net service revenues increased ... increased 61% to $212.6 million- Fourth quarter Visiting Nurse ... full year VN net revenues rose 80% to $173.0 ... million; full year net income increased 114% to $16.3 ...
... Demonstrates Ability to Treat Subcutaneous InfectionsEMERYVILLE, Calif., March ... a clinical stage biopharmaceutical company, today announced that ... molecule in NovaBay,s, proprietary Aganocide(R) class of compounds, ... Dermatology (AAD) 67th Annual Meeting in San Francisco ...
... LOUIS, Missouri, March 4 Elsevier,world-leading publisher of ... pleased to announce the July 2009 launch of ... American College of,Osteopathic Family Physicians (ACOFP), Osteopathic Family ... Physician, Official Journal of the American College of,Osteopathic ...
... help him find the surgeon in India his U.S. cardiologist recommended. Just ... overseas completed. He,s now home and enjoying his new lease on life. ... ... his chronic fatigue was due to a problem with his heart,s mitral valve, ...
Cached Medicine News:Health News:Fingertip Formulary Analytics(R) Offers One-Click Access to Customized Formulary Data and Co-Pay Reports 2Health News:Health Integrated Enjoys Steady Growth 2Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 2Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 3Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 4Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 5Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 6Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 7Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 8Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 9Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 10Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 11Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 12Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 13Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 14Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 15Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 16Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 17Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 18Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 19Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 20Health News:NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting 2Health News:NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting 3Health News:Elsevier Announces Launch of Osteopathic Family Physician Publishing Partnership Formed With American College of Osteopathic Family Physicians 2Health News:Elsevier Announces Launch of Osteopathic Family Physician Publishing Partnership Formed With American College of Osteopathic Family Physicians 3Health News:Ohio Patient Thanks India and WorldMed Assist For Heart Surgery Overseas; His Indian Surgeon Thanks U.S. for Superb Training 2Health News:Ohio Patient Thanks India and WorldMed Assist For Heart Surgery Overseas; His Indian Surgeon Thanks U.S. for Superb Training 3
(Date:7/24/2014)... July 24, 2014  Mettler-Toledo International Inc. (NYSE: ... 2014.  Provided below are the highlights: , ... quarter compared with the prior year. Reported sales increased ... , Net earnings per diluted share as reported (EPS) ... of 2013. Adjusted EPS was $2.57, an increase of ...
(Date:7/24/2014)... 24, 2014 Omnicell, Inc. (NASDAQ: ... and supply management solutions and analytics software for ... 31, to discuss the Company,s Second Quarter 2014 ... 2014 earnings conference call and webcastWhen: , ... Lipps, chairman, president and chief executive officer ...
(Date:7/24/2014)... and MENLO PARK, Calif. , July 24, ... ("DelMar" "the company") announced today that the company,s board of ... December 31 to June 30. Accordingly, DelMar will file a ... Jeffrey Bacha , president and CEO of DelMar ... step in achieving our goal of obtaining a senior exchange ...
Breaking Medicine Technology:Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 14Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 3
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... chairs are recommended for the following ... static control, health care and office. ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
Medicine Products: