Navigation Links
Scientists ID Brain Pathway That Stops Seizures
Date:6/8/2008

Mouse study finds gene affects acids that regulate severity of convulsions

SUNDAY, June 8 (HealthDay News) -- A brain pathway that stops seizures has been found by Iowa researchers.

Applying modern genetics and molecular biology to clinical observations made more than 80 years ago, a team from the University of Iowa and the Veterans Affairs Iowa City Health Care System found that increased acid (pH) activates an ion channel in the brain that shuts down seizure activity. The findings were expected to be published online June 8 in Nature Neuroscience.

"Although this work provides insight into how seizures normally stop and might help us learn more about how to terminate those seizures that don't stop, it will take more work to turn the finding into a new therapeutic approach," senior study author Dr. John Wemmie, an assistant professor of psychiatry in the University of Iowa's Roy J. and Lucille A. Carver College of Medicine, said in a prepared statement. "We will be working with colleagues in neurology and neurosurgery to try and translate the findings to treatments."

Clinical experiments from the first half of the 20th century show breathing carbon dioxide, which creates more acid in brain tissue, helps stop epileptic seizures while the seizures themselves lower brain pH. The modern discovery of an acid-activated ion channel (ASIC1a) in the brain helped the team piece the puzzle together.

"We found that ASIC1a does not seem to play a role in how a seizure starts, but as the seizure continues, and the pH is reduced, ASIC1a appears to play a role in stopping additional seizure activity," study co-lead author Adam Ziemann, a student in the Medical Scientist Training Program at the university, said in a prepared statement.

Researchers found that seizures are more severe and longer in mice lacking the ASIC1a gene than those with the gene. Also, chemically blocking ASIC1a causes the se
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Long-acting insulin is safer and more effective than ... according to new research published in the ... and twice-daily doses of both long- and intermediate-acting ... , "In patients with Type 1 diabetes, we ... insulin when it came to controlling blood sugar, ...
(Date:10/1/2014)... holiday gift ideas? Éminence Organic Skin Care, the leader in ... season. Starting October 1st 2014, new spa gift sets are ... from two luxury skin care gift sets made from the ... to deliver whole body beauty. , The luxurious Body ... formulated to suit all skin types and will tick all ...
(Date:10/1/2014)... To help raise awareness about women’s health, leading Detroit ... several tips for women looking to live a healthier and ... should start each day with meditation, prayer and breathing exercises. ... yourself for the rest of the day and prevent the ... and fitness tips include:, -Drink half your weight in ounces ...
(Date:9/30/2014)... proactive about potential disease outbreaks like Ebola and establish ... Editorial in the October issue of Australian and ... from Monash University and Heath Kelly from the Australian ... , "Australia would do well to heed the lessons ... a consistent and outward looking response," the authors said. ...
(Date:9/30/2014)... conceived either less than one year or more than five ... increased risk for autism, a new study suggests. However, ... that the research can,t prove that birth spacing has any ... that parents understand that the odds for autism are still ... apart," said outside expert Dr. Andrew Adesman. He is chief ...
Breaking Medicine News(10 mins):Health News:Long-acting insulin is safer, more effective for patients with Type 1 diabetes 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 3Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2Health News:Spacing Between Sibling Births Tied to Autism Risk in Study 2
... food to infants less than six months old is not ... allergies later and new moms should rather breastfeed them exclusively, ... avoided for the first six months, and certain items like ... until even later, according to the American College of Allergy, ...
... Consuming naturally occurring compounds in cocoa could improve ... also help blood flow// in menopausal women with ... and gives us new insights into how cocoa ... ways not previously known,' said Harold Schmitz, PhD, ...
... embryo formation has been discovered in malignant melanoma cells ... Scientist discovered this protein called Nodal by injecting malignant ... were able to induce abnormal embryonic skull and backbone ... published in online issue of the journal, Nature Medicine. ...
... the researchers at the University of Florida, Gainesville, mice based ... treat hereditary diseases of the heart.// , This ... with muscular dystrophy that damages the heart. The findings, published ... the way for studies in humans that could begin as ...
... Health service helpline NHS 24 has been criticized severely because a ... old lady.// ,Retired nurse Mary Smith, 87 had an ... helpline twice but the nurse curtly replied that she could not ... for a GP to attend to her. Then when the GP ...
... Hyderabad-based Aurobindo Pharma Ltd today said it has ... fixed drug combination product used for anti-HIV treatment. ... contains Lamivudine 150mg+2idovudine300mg tablets co-packaged with Abacavir 300mg ... ,This combination pack enhances convenience, is cost-effective ...
Cached Medicine News:Health News:Protein Involved In Embryo Formation Found In Malignant Cells 2Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 2Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 3Health News:Gene Therapy Technique for Inherited Heart Problems in The Pipeline 4
(Date:9/30/2014)... Sept. 30, 2014 Arbor Pharmaceuticals, LLC. ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - ... of the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Arbor ... stages, therapeutics assessment by drug target, mechanism of ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... Combination with CRESTOR (rosuvastatin calcium) Demonstrates Similar Lipid Effects ... ... Population, SAN FRANCISCO, June 7 ... type 2 diabetes,that were enrolled in a Phase III study showed ...
... the ADA,s Annual Scientific Sessions, SAN FRANCISCO, ... of the dose-finding study for its new,injectable diabetes ... American Diabetes Association,s (ADA) 68th Annual Scientific Sessions,meeting ... that AVE0010 was well tolerated and significantly,improved glycemic ...
Cached Medicine Technology:Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 2Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 3Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 4New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 2New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 3New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 4
DNA/RNA preparation in 8-multi channels...
... units with hydrophobic PTFE membranes,Millex filter ... ideal for the sterilizing filtration of ... and for sterilizing or clarifying organic ... filter units are available with different ...
... Bottled Water, The Simplicity personal water system ... currently use bottled water. In addition to ... store bottled water, your laboratory applications may ... be absorbed from containers and cause water ...
... of Type I ultrapure water, , Ultrapure ... System is designed to provide the "final ... by reverse osmosis, distillation or deionization. Super-Q ... which exceeds Type I ASTM/CAP/NCCLS specifications.,The Super-Q ...
Medicine Products: