Navigation Links
Scientists ID Antibody That Might Boost Cancer Therapy
Date:3/14/2013

THURSDAY, March 14 (HealthDay News) -- A new monoclonal antibody that can target proteins inside cancer cells has been developed by researchers and tested in the laboratory and in mice.

Monoclonal antibodies are naturally occurring human antibodies that are genetically altered in a laboratory, cloned in large numbers and introduced into the patient to target disease sites.

In the new study, a monoclonal antibody, called ESK1, targets a protein associated with many types of cancer.

The targeted protein, called WT1, is over-produced in a range of leukemias and other cancers, including myeloma and breast, ovarian and colorectal cancers. WT1 is an oncogenic protein, which means it supports the formation of cancer.

Because WT1 is found in few healthy cells, patients are less likely to suffer side effects from drugs that would potentially target the protein, the researchers said.

"This is a new approach for attacking WT1, an important cancer target, with an antibody therapy," Dr. David Scheinberg, an inventor of the antibody, said in a news release from the Memorial Sloan-Kettering Cancer Center in New York City. "This is something that was previously not possible."

"There has not been a way to make small molecule drugs that can inhibit WT1 function," said Scheinberg, who is chairman of the molecular pharmacology and chemistry program at the center. "Our research shows that you can use a monoclonal antibody to recognize a cancer-associated protein inside a cell, and it will destroy the cell."

Although studies involving animals can be useful, they frequently fail to produce similar results in humans.

In laboratory research, the antibody showed promise as a treatment for leukemia, the researchers said. Their findings appear in the March 13 issue of the journal Science Translational Medicine.

The Sloan-Kettering researchers created the new antibody in collaboration with Eureka Therapeutics.

More information

The American Academy of Family Physicians outlines current cancer treatments.

-- Robert Preidt

SOURCE: Memorial Sloan-Kettering Cancer Center, news release, March 13, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Report Clues to Flu Shots Effectiveness
2. Scientists discuss relationship between abortion and violence against women
3. A*STAR scientists discover switch critical to wound healing
4. Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
5. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
6. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
7. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
8. Scientists make older adults less forgetful in memory tests
9. Scientists unveil secrets of important natural antibiotic
10. Fungi offers new clues in asthma fight, say Cardiff scientists
11. Scientists find promising new approach to preventing progression of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Antibody That Might Boost Cancer Therapy
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... to catalyze conversations in support of bold systems change models helping to achieve ... an event on September 21, 2017, “We the Future: Accelerating Sustainable Development Solutions” ...
(Date:8/17/2017)... ... August 17, 2017 , ... SeQuel Response announced today that for ... among the fastest-growing private companies in the U.S., putting it in the top 10 ... applied to the Inc. 5000 over the years, only a fraction have ...
(Date:8/17/2017)... ... 2017 , ... Dr. Charles W. Grimsley’s new book ... 9781498497626; $7.99, eBook, 9781498497633) focuses on the treatment of veterans diagnosed with posttraumatic ... through a progressive journey toward healing. This book will help readers learn to ...
(Date:8/17/2017)... ... August 17, 2017 , ... Momkus McCluskey Roberts LLC recently ... is a member of the firm’s Commercial Litigation and Employment Law groups. , Ms. ... of knowledge in matters of employment litigation, commercial litigation and business disputes. Her experience ...
(Date:8/17/2017)... ... August 17, 2017 , ... A recent report indicates that circa 79 percent ... cited deficiencies in data integrity. The FDA outlines their expectations for quality critical instrumentation ... as part of the Beckman Coulter Life Sciences Virtual Trade Show Virtual ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that its Board of Directors has approved the payment ... quarter of 2017. The ... or about October 27, 2017 to stockholders of record as ... declarations of dividends are subject to approval of the Board ...
(Date:8/7/2017)... Mich., Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), ... the quarter ended June 30, 2017.  All comparisons, unless otherwise ... Second Quarter 2017 Highlights ... to $1,089 million, an increase of 3.5% ... Gross margin of 7.5% versus 7.6% ...
(Date:8/4/2017)... 4, 2017 The search for test results ... physician/patient consult has long been the goal of healthcare ... focus of the largest meeting of lab professionals and ... market research firm Kalorama Information.  The firm said scores ... or related supplies and software were at the American ...
Breaking Medicine Technology: