Navigation Links
Scientists ID Antibody That Might Boost Cancer Therapy
Date:3/14/2013

THURSDAY, March 14 (HealthDay News) -- A new monoclonal antibody that can target proteins inside cancer cells has been developed by researchers and tested in the laboratory and in mice.

Monoclonal antibodies are naturally occurring human antibodies that are genetically altered in a laboratory, cloned in large numbers and introduced into the patient to target disease sites.

In the new study, a monoclonal antibody, called ESK1, targets a protein associated with many types of cancer.

The targeted protein, called WT1, is over-produced in a range of leukemias and other cancers, including myeloma and breast, ovarian and colorectal cancers. WT1 is an oncogenic protein, which means it supports the formation of cancer.

Because WT1 is found in few healthy cells, patients are less likely to suffer side effects from drugs that would potentially target the protein, the researchers said.

"This is a new approach for attacking WT1, an important cancer target, with an antibody therapy," Dr. David Scheinberg, an inventor of the antibody, said in a news release from the Memorial Sloan-Kettering Cancer Center in New York City. "This is something that was previously not possible."

"There has not been a way to make small molecule drugs that can inhibit WT1 function," said Scheinberg, who is chairman of the molecular pharmacology and chemistry program at the center. "Our research shows that you can use a monoclonal antibody to recognize a cancer-associated protein inside a cell, and it will destroy the cell."

Although studies involving animals can be useful, they frequently fail to produce similar results in humans.

In laboratory research, the antibody showed promise as a treatment for leukemia, the researchers said. Their findings appear in the March 13 issue of the journal Science Translational Medicine.

The Sloan-Kettering researchers created the new antibody in collaboration with Eureka Therapeutics.

More information

The American Academy of Family Physicians outlines current cancer treatments.

-- Robert Preidt

SOURCE: Memorial Sloan-Kettering Cancer Center, news release, March 13, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Report Clues to Flu Shots Effectiveness
2. Scientists discuss relationship between abortion and violence against women
3. A*STAR scientists discover switch critical to wound healing
4. Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
5. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
6. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
7. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
8. Scientists make older adults less forgetful in memory tests
9. Scientists unveil secrets of important natural antibiotic
10. Fungi offers new clues in asthma fight, say Cardiff scientists
11. Scientists find promising new approach to preventing progression of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Antibody That Might Boost Cancer Therapy
(Date:6/27/2016)... NY (PRWEB) , ... June 27, 2016 , ... ... using cutting edge technology to revolutionize the emergency ambulance transport experience for the ... are aware of how Uber has disrupted the taxi industry through the use ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... firsts,: , TwinLink™ - the first dual ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: