Navigation Links
Scientists ID Antibody That Might Boost Cancer Therapy
Date:3/14/2013

THURSDAY, March 14 (HealthDay News) -- A new monoclonal antibody that can target proteins inside cancer cells has been developed by researchers and tested in the laboratory and in mice.

Monoclonal antibodies are naturally occurring human antibodies that are genetically altered in a laboratory, cloned in large numbers and introduced into the patient to target disease sites.

In the new study, a monoclonal antibody, called ESK1, targets a protein associated with many types of cancer.

The targeted protein, called WT1, is over-produced in a range of leukemias and other cancers, including myeloma and breast, ovarian and colorectal cancers. WT1 is an oncogenic protein, which means it supports the formation of cancer.

Because WT1 is found in few healthy cells, patients are less likely to suffer side effects from drugs that would potentially target the protein, the researchers said.

"This is a new approach for attacking WT1, an important cancer target, with an antibody therapy," Dr. David Scheinberg, an inventor of the antibody, said in a news release from the Memorial Sloan-Kettering Cancer Center in New York City. "This is something that was previously not possible."

"There has not been a way to make small molecule drugs that can inhibit WT1 function," said Scheinberg, who is chairman of the molecular pharmacology and chemistry program at the center. "Our research shows that you can use a monoclonal antibody to recognize a cancer-associated protein inside a cell, and it will destroy the cell."

Although studies involving animals can be useful, they frequently fail to produce similar results in humans.

In laboratory research, the antibody showed promise as a treatment for leukemia, the researchers said. Their findings appear in the March 13 issue of the journal Science Translational Medicine.

The Sloan-Kettering researchers created the new antibody in collaboration with Eureka Therapeutics.

More information

The American Academy of Family Physicians outlines current cancer treatments.

-- Robert Preidt

SOURCE: Memorial Sloan-Kettering Cancer Center, news release, March 13, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Report Clues to Flu Shots Effectiveness
2. Scientists discuss relationship between abortion and violence against women
3. A*STAR scientists discover switch critical to wound healing
4. Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
5. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
6. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
7. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
8. Scientists make older adults less forgetful in memory tests
9. Scientists unveil secrets of important natural antibiotic
10. Fungi offers new clues in asthma fight, say Cardiff scientists
11. Scientists find promising new approach to preventing progression of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Antibody That Might Boost Cancer Therapy
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/19/2017)... HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform ... leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
Breaking Medicine Technology: