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Scientists Hot on Trail of New Antibiotics
Date:10/17/2008

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"It's an amazing site," Eddy Arnold, also of Rutgers University, said of this hinge that the researchers refer to as a switch region. "It's a drug designer's dream, because it's a pocket that can accommodate a variety of chemical inhibitors."

Myxopyronin and corallopyronin appear to work against a broad range of infectious diseases including TB, according to the researchers. The current treatment for TB, rifamycins, requires six months to two years of therapy, depending on whether the person can tolerate the drugs or whether the strain of TB the person has is resistant to antibiotics.

The researchers said that antibiotics targeting this RNA polymerase hinge cut treatment time down to as little as two weeks.

More information

The American Lung Association has more about tuberculosis.



-- Kevin McKeever



SOURCE: Cell Press, news release, Oct. 16, 2008


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Scientists Hot on Trail of New Antibiotics
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