Navigation Links
Scientists Hot on Trail of New Antibiotics
Date:10/17/2008

Natural compounds could mean faster treatments for TB, fight other drug-resistant bacteria

FRIDAY, Oct. 17 (HealthDay News) -- Researchers believe they are close to perfecting a new class of broad-spectrum antibiotics that could counter increasingly drug-resistant bacteria, a new study says.

The new antibiotics compounds -- all of which are natural products produced by certain bacteria to battle other bacteria -- also show promise as a more effective and faster treatment for tuberculosis. One in three people worldwide carries TB, and today's antibiotics are not efficient in combating it.

The new research, published in the Oct. 17 issue of the journal Cell, is encouraging, because bacterial infectious diseases are responsible for a quarter of all deaths worldwide. For all major bacterial pathogens, strains resistant to at least one current antibiotic have arisen, according to one researcher.

"For six decades, antibiotics have been our bulwark against bacterial infectious diseases," Richard Ebright, a Howard Hughes Institute investigator at Rutgers University, said in an interview issued by the journal's publisher. "Now, this bulwark is collapsing. There is an urgent need for new antibiotic compounds and practical new targets."

The new antibiotic compounds under study are myxopyronin, corallopyronin, and ripostatin. They block the action in bacteria of RNA polymerase, an essential protein in all organisms that is necessary to transcribe the genetic instructions in DNA into RNA, which in turn directs the assembly of proteins.

"RNA polymerase has a shape reminiscent of a crab claw, with two prominent pincer-like projections," Ebright said. "Just as with a real crab claw, one pincer stays fixed and one pincer moves, opening and closing to keep DNA in place. The pincer that moves does so by rotating about a hinge. Our studies show that the three antibiotics bind to and jam this hinge."

"It's an amazing site," Eddy Arnold, also of Rutgers University, said of this hinge that the researchers refer to as a switch region. "It's a drug designer's dream, because it's a pocket that can accommodate a variety of chemical inhibitors."

Myxopyronin and corallopyronin appear to work against a broad range of infectious diseases including TB, according to the researchers. The current treatment for TB, rifamycins, requires six months to two years of therapy, depending on whether the person can tolerate the drugs or whether the strain of TB the person has is resistant to antibiotics.

The researchers said that antibiotics targeting this RNA polymerase hinge cut treatment time down to as little as two weeks.

More information

The American Lung Association has more about tuberculosis.



-- Kevin McKeever



SOURCE: Cell Press, news release, Oct. 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Hot on Trail of New Antibiotics
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: