Navigation Links
Scientists Gain Insight Into Blood Cancer's Progression
Date:2/20/2009

Findings for chronic myeloid leukemia may have wider implications, researchers say

FRIDAY, Feb. 20 (HealthDay News) -- U.S. researchers say they've spotted a mechanism by which chronic myeloid leukemia (CML) progresses into a deadlier stage.

The finding may improve patient outcomes, they said.

The researchers found that when a molecular off-switch called glycogen synthase kinase (GSK) 3 beta becomes faulty in chronic stage CML cells, it fails to turn off another protein called beta-catenin. This enables pre-leukemia stem cells to develop into leukemia stem cells and increase their numbers, leading to the more dangerous "blast crisis" state of CML.

"If we can predict when a patient is moving from the chronic phase in CML to the blast crisis stage, then we can hopefully intervene before it's too late," study co-leader Dr. Catriona H.M. Jamieson, an assistant professor of medicine at the University of California, San Diego (UCSD) School of Medicine and director for Stem Cell Research at the Moores UCSD Cancer Center, said in a university news release.

Faulty GSK 3 beta also offers a potential treatment target, the researchers said. "This knowledge may enable us to design and develop more effective, personalized therapies for these patients," co-first author and staff research associate Annelie Abrahamsson said in the news release.

The study appears online in this week's issue of the Proceedings of the National Academy of Sciences.

The findings may not be limited to CML, the team noted.

"Downregulating beta-catenin and GSK deregulation may have other implications in many cancers," Jamieson said. "By studying CML, we can understand the molecular evolution of disease and the stepwise progression to cancer. It becomes a useful paradigm for understanding how cancers evolve and the pathways that are essential to escape the normal control mechanisms."

More information

The U.S. National Cancer Institute has more about chronic myeloid leukemia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Feb. 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
2. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
3. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
4. Scientists uncover secrets of potential bioterror virus
5. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
6. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
7. Scientists Heartened at Prospect of End to Stem Cell Ban
8. Scientists discover key factor in controlling the breakdown of bone
9. Team led by Scripps Scientists increases understanding of two types of blindness
10. CSHL scientists discover link between control of chromosome duplication and segregation
11. UCSB scientists make headway in understanding Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Gain Insight Into Blood Cancer's Progression
(Date:2/19/2017)... Viejo, CA (PRWEB) , ... February 19, 2017 , ... ProBrand Glitch is a set ... . With ProBrand Glitch users can easily reveal any logo with a glitch reveal in ... X users control over the style and animation of each preset. Use these presets to ...
(Date:2/18/2017)... , ... February 17, 2017 , ... ... source of disruptive innovation in the industry, according to the recent NEJM Catalyst ... based on surveys of the NEJM Catalyst Insights Council, a qualified group of ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX ... applications. Users can pick and choose from hand-crafted trend-setting designs with smooth ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance Healthcare Foundation ... to further positively impact the health and wellness of our community in San ... our duty to seriously consider releasing our assets beyond our 5% targeted distribution ...
(Date:2/17/2017)... Verdes, CA (PRWEB) , ... February 17, 2017 ... ... emotional flow is Dr. Carol Francis' goals for each and every ... Conference, Dr. Carol Francis will demonstrate five different brainwave tools which help energize ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... February 20, 2017 The ... USD 58.4 billion by 2025, according to a ... market is driven by technological advancements in veterinary ... opportunities to the market. For instance, MediLabSecure, a ... of identifying emerging viruses and pathogens in 19 ...
(Date:2/20/2017)... LONDON , February 20, 2017 Acute, Chronic ... is expected to grow at a CAGR of 7% from 2016-2021 and ... a CAGR of 6% from 2016 to 2027. The market is estimated ... ... Read on to discover how you can exploit the future business ...
(Date:2/18/2017)... PORT WASHINGTON, N.Y. , Feb. 17, 2017 ... law firm dedicated to protecting the rights of ... device problems have prompted regulators to call for ... events in 1990. Safety concerns involving ... and Drug Administration (FDA) to investigate how hospitals ...
Breaking Medicine Technology: