Navigation Links
Scientists Gain Insight Into Blood Cancer's Progression
Date:2/20/2009

Findings for chronic myeloid leukemia may have wider implications, researchers say

FRIDAY, Feb. 20 (HealthDay News) -- U.S. researchers say they've spotted a mechanism by which chronic myeloid leukemia (CML) progresses into a deadlier stage.

The finding may improve patient outcomes, they said.

The researchers found that when a molecular off-switch called glycogen synthase kinase (GSK) 3 beta becomes faulty in chronic stage CML cells, it fails to turn off another protein called beta-catenin. This enables pre-leukemia stem cells to develop into leukemia stem cells and increase their numbers, leading to the more dangerous "blast crisis" state of CML.

"If we can predict when a patient is moving from the chronic phase in CML to the blast crisis stage, then we can hopefully intervene before it's too late," study co-leader Dr. Catriona H.M. Jamieson, an assistant professor of medicine at the University of California, San Diego (UCSD) School of Medicine and director for Stem Cell Research at the Moores UCSD Cancer Center, said in a university news release.

Faulty GSK 3 beta also offers a potential treatment target, the researchers said. "This knowledge may enable us to design and develop more effective, personalized therapies for these patients," co-first author and staff research associate Annelie Abrahamsson said in the news release.

The study appears online in this week's issue of the Proceedings of the National Academy of Sciences.

The findings may not be limited to CML, the team noted.

"Downregulating beta-catenin and GSK deregulation may have other implications in many cancers," Jamieson said. "By studying CML, we can understand the molecular evolution of disease and the stepwise progression to cancer. It becomes a useful paradigm for understanding how cancers evolve and the pathways that are essential to escape the normal control mechanisms."

More information

The U.S. National Cancer Institute has more about chronic myeloid leukemia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Feb. 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
2. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
3. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
4. Scientists uncover secrets of potential bioterror virus
5. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
6. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
7. Scientists Heartened at Prospect of End to Stem Cell Ban
8. Scientists discover key factor in controlling the breakdown of bone
9. Team led by Scripps Scientists increases understanding of two types of blindness
10. CSHL scientists discover link between control of chromosome duplication and segregation
11. UCSB scientists make headway in understanding Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Gain Insight Into Blood Cancer's Progression
(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... N.J. (PRWEB) , ... October 13, 2017 , ... The ... Holly Day Market. Featuring a collection of specialty vendors and unique items from across ... personalized and quality-focused health and wellness services offered by the VNA. The boutique ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
Breaking Medicine Technology: