Navigation Links
Scientists Find Way to Partially Reverse Aging in Mice
Date:11/29/2010

SUNDAY, Nov. 28 (HealthDay News) -- U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective "caps" on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. Ronald A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

"Whether this would impact on normal aging is a more difficult question," he said in the news release. "But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline."

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

"If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged," he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

More information

The Mass.gov Web site offers tips for healthy aging.

-- Robert Preidt

SOURCE: Dana-Farber Cancer Institute, news release, Nov. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Way to Partially Reverse Aging in Mice
(Date:1/13/2017)... ... January 13, 2017 , ... The 18th European Congress: Perspectives in ... March 3-4, 2017. This Congress is expertly designed to meet the educational needs ... with lung cancer. , Chaired by Dr. Giorgio V. Scagliotti, Professor of Oncology at ...
(Date:1/13/2017)... ... ... inventor from Pahrump, Nev., used an unsavory medical experience to think of a way to ... urine bag for a half year due to lazy bladder," he said. "Keeping these things ... better way to do this." , He then designed and created a prototype of the ...
(Date:1/13/2017)... , ... January 13, 2017 , ... Friday, January 13 ... of the game room, increasing the size of the location to 90,000 square feet. ... 8-hole mini golf course that takes customers on an educational tour of the historic ...
(Date:1/13/2017)... ... January 13, 2017 , ... As the nation watches this month’s transition ... colleges and schools of education across the country is urging a fundamental reconsideration of ... Principles released today, 175 deans sounded the alarm: “Our children suffer when we deny ...
(Date:1/13/2017)... ... January 13, 2017 , ... One way to obtain a green card is ... can show their work is in the national interest. There are two significant advantages ... be sponsored by an employer; and 2) the submission is made directly to the ...
Breaking Medicine News(10 mins):
(Date:1/12/2017)... -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing ... this week,s Orlando Dermatology Aesthetic & Clinical (ODAC) Conference, which ... inflammation. The data will be shared in a ... at ODAC, which is being held Jan. 13-16 in ... ...
(Date:1/12/2017)...   TyrNovo , s NT219 drug candidate ... cancer drug resistance and would be ... NT219 is a novel proprietary ... ( IRS1/2 and STAT3) highly involved in ... .   NT219 has demonstrated ...
(Date:1/12/2017)... -- "Global Lung Cancer Vaccine Market & Pipeline ... trends in the global lung cancer vaccine market. ... available in the market. This report analyzes the ... in clinical pipeline and gives comprehensive clinical insight ... the lung cancer vaccines. Currently there are 9 ...
Breaking Medicine Technology: