Navigation Links
Scientists Find Way to Partially Reverse Aging in Mice
Date:11/29/2010

SUNDAY, Nov. 28 (HealthDay News) -- U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective "caps" on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. Ronald A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

"Whether this would impact on normal aging is a more difficult question," he said in the news release. "But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline."

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

"If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged," he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

More information

The Mass.gov Web site offers tips for healthy aging.

-- Robert Preidt

SOURCE: Dana-Farber Cancer Institute, news release, Nov. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Way to Partially Reverse Aging in Mice
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial ... financial preparation services, is providing an update on a charitable event that began ... Rescue is a locally recognized nonprofit that provides shelter and care for animals ...
(Date:10/13/2017)... ... 13, 2017 , ... PurhealthRX , a leading Health and Nutrition Company, ... Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market by ... be easily incorporated into liquid products, while reducing costs to end users. , The ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: