Navigation Links
Scientists Find Way to Heal Broken Bones Faster
Date:4/28/2010

Mouse study suggests Wnt protein might help humans with fractures, too

WEDNESDAY, April 28 (HealthDay News) -- Stanford researchers have found a way to significantly speed up the healing of broken bones in mice, a feat which, if replicated in humans, could mean people with fractures would be free of their casts a lot sooner.

"This has huge implications," said Dr. Victor Khabie, co-director of the Orthopedic and Spine Institute at Northern Westchester Hospital in Mt. Kisco, N.Y. "Broken bones is a big problem, and this is just the tip of the iceberg."

The technique could help in fusing bones as well, and many other surgeries that rely on bone growth and bone healing to succeed, he added.

"A lot of the surgeries we do rely on bone growth and bone healing, and a lot of the failures of surgery have to do with the fact that the bone never heals or the fusion never [takes]," Khabie explained.

And this might have applications beyond bones.

"It isn't limited to bone injuries," said Dr. Jill Helms, senior author of the study published in the April 28 issue of Science Translational Medicine. "There's a lot of interest in the role that [the protein used in these experiments] plays in tissue repair and tissue regeneration."

That also includes blood, neural and cardiac cells, added Helms, who is a professor of surgery and of plastic and reconstructive surgery at Stanford University School of Medicine.

The research borrowed a chapter from the lives of animals that can regenerate on their own, such as zebrafish and flat worms.

Scientists already knew that this capability was partly due to a class of proteins called Wnt proteins.

Although mammals don't have the same innate ability to regenerate, the researchers speculated that, with a little help from Wnt proteins, maybe they could.

The researchers actually conducted two experiments, both testing the idea that tissues might heal faster if the Wnt signal was ramped up.

The first used a genetic approach, involving mice that had been genetically engineered to respond better to a Wnt signal, then administering purified Wnt via fat particles known as liposomes.

The second strategy involved raising levels of the Wnt protein in normal mice. Both groups of mice had sustained bone injuries.

"Both experiments showed us the same thing, that when Wnt signals were prolonged in an injury site then healing was much more robust," Helms reported. "When we delivered this form of the protein in a little lipid [fat] particle to an injury site, we accelerated the healing quite dramatically."

In fact, within the first three days, those mice had 3.5 times more new bone than the mice in the other groups, according to background information about the study.

Helms and her colleagues believe Wnt causes bone stem cells to divide more and turn into bone-forming cells much sooner.

J. Edward Puzas, a professor of orthopedics and senior associate dean for basic research at the University of Rochester Medical Center, added that the idea might also benefit people who sustain potentially life-threatening fractures as a result of osteoporosis.

In separate ongoing studies, Puzas is finding that the osteoporosis drug Forteo is also useful in healing bones.

The Stanford group is now expanding its work to speed tissue regeneration after skin wounds, heart attacks and stroke.

More information

The American Academy of Orthopaedic Surgeons has more on bone fractures.



SOURCES: Jill Helms, Ph.D., DDS, professor, surgery and plastic and reconstructive surgery, Stanford University School of Medicine, Palo Alto, Calif.; Victor Khabie, co-director, Orthopedic and Spine Institute, Northern Westchester Hospital, Mt. Kisco, N.Y.; J. Edward Puzas, Ph.D., professor, orthopedics, and senior associate dean, basic research, University of Rochester Medical Center, Rochester, N.Y.; April 28, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists Report Key Finding in Breast Cancer Research
2. Rutgers Stem Cell Research Center derives new cell lines and trains stem cell scientists
3. CSHL scientists discover how a tumor suppressor induces senescence and staves off cancer
4. Scientists find key to gene that promotes cancer metastasis
5. Scientists find gene linked to schizophrenia
6. Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists
7. Scientists Grow Replacement Blood Vessels From Stem Cells
8. Southampton scientists begin Phase II patient trial for new asthma treatment
9. Scientists find out why living things are the size they are -- and none other
10. Scientists: Soccer improves health, fitness and social abilities
11. Pan-Asian hub for life scientists to open in Suzhou, China, on Monday, April 6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
Breaking Medicine Technology: