Navigation Links
Scientists Find New Key to Lupus
Date:10/19/2009

Molecule identified in lab mice may cause autoimmune disease

MONDAY, Oct. 19 (HealthDay News) -- Researchers say they've gained new understanding of how lupus develops in mice, a finding that could help future treatments for the autoimmune disease.

An estimated 1.5 million to 2 million people in the United States suffer from lupus, a disorder in which the body's defenses turn inward. The condition can cause symptoms similar to those of arthritis and rheumatic diseases.

At issue is the immune system's ability to take out the trash -- to get rid of cells that don't have long to live. "Just like in mice, in humans, if you don't clear the dying cells, then that predisposes you to lupus," said Lata Mukundan, a Stanford University School of Medicine researcher and co-author of a study published online Oct. 18 in the journal Nature Medicine.

"If you look at patients with lupus, they have an inability to clear those dead cells," Mukundan said in a statement.

The study authors report that they gained insight into how immune-system cells detect which other cells are dying in order to dispose of them. They looked at human and mouse cells outside the body and in genetically engineered mice.

The researchers suspected that a molecule known as PPAR-delta was crucial to the process. "We wanted to know, if you took a mouse and only deleted PPAR-delta from its macrophages, is that sufficient to cause an autoimmune disease?" asked Dr. Ajay Chawla, assistant professor of endocrinology and co-author of the study, in a statement. "Apparently it is," he said.

The researchers say currently existing drugs activate the molecule in question. Perhaps, they say, the drugs could treat lupus.

More information

Learn more about lupus from the National Institutes of Health.




'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Health care is only part of the puzzle: Social scientists analyze societys health and success
2. Scientists Provide First Map of Complete Human Epigenome
3. New Professional Network Brings Chinese Scientists and Researchers into International Community
4. Hutchinson Center scientists net $16.7 million for stem cell research
5. USC neuroscientists awarded $9 million to map gene expression during human brain development
6. Duke/Singapore scientists find new way to classify gastric cancers
7. Scripps research scientists find missing puzzle piece of powerful DNA repair complex
8. Scientists decipher missing piece of first-responder DNA repair machine
9. University of Louisville neuroscientists hope to get people walking again
10. Oldest Skeleton in Human Family Tree Surprises Scientists
11. Scientists find obesity alone does not cause arthritis in animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Young women starting college understand the benefits of a ... But they aren,t confident they can follow through on ... The study involved 268 female college freshmen ... and Eating Right program. The students answered food-related questions ... they were very busy with school work, were very ...
(Date:9/21/2014)... To accommodate the ever-growing customer base, Angeldress.co.uk decided to ... Recently, the company has unveiled its 2014 vintage ... wedding gowns, Angeldress.co.uk wants to make sure that all ... way. Its high quality vintage wedding outfits are now ... 62% off. , Online shopping is becoming more and ...
(Date:9/21/2014)... BambooIndustry.com, an experienced producer of natural bamboo items, has ... http://www.bambooindustry.com/products/bamboo-panel/ ). The company’s excellent panels are very popular ... discounted prices now, from 10 to 30 percent off. ... are available in many specifications; they are promised to ... finely manufactured by qualified workers. They are specially offered ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 Top10BestSEOHosting.com, ... ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the most ... want to buy high quality hosting products. ... good hosting suppliers; we recommend two great hosting ... says, “We believe that iPage and GreenGeeks are ...
(Date:9/20/2014)... 6 Minutes to Skinny , a fat ... that is showing men and women of all ages how ... fat using simple 6-minute exercises and easy-to-follow lifestyle tips daily, ... review. , “When it comes to losing body fat, ... for all people,” reports Michaels. “Metabolism plays a big role ...
Breaking Medicine News(10 mins):Health News: College Women Can Use Food Strategies, Study Finds 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2Health News:Discounted Bamboo Panels For Sale At BambooIndustry.com 2Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2
... use of narcotics for chronic pain in elderly works, ... the dose. On the other hand, the use of ... increase in the dosage with serious health repercussions. ... morphine, methadone and oxycodone. Opioid drugs are used for ...
... for creating stem cells that may be used to help ... lines are an exact match with the patients’ DNA and ... into using stem cells cloned from the persons to use ... first time human embryonic stem cells have been found suitable ...
... New study had found out that colonoscopy may be ... ,For patients suspected with colorectal cancer, flexible sigmoidoscopy ... of 1cm in diameter, adenomas with dysplasia, or cancer. ... neoplasia that may be cancerous for women who were ...
... may increase the risk of bacterial infection of the lungs, ... Medicine. ,Researchers had studied persons of age between 2 ... each of 635 persons with invasive pneumococcal disease, 10 persons ... defined by the study as proof of diagnosis of asthma ...
... among patients of colon cancer after undergoing surgery can reduce ... a study which was presented at the annual meeting of ... recurrence reduces by about 50% for the patients who took ... from colon cancer. ,Colon and rectum together form the ...
... Children suffering from Attention Deficit Hyperactivity Syndrome (ADHD) may ... help of sensory interventions like applying deep pressure or ... Hyperactivity Disorder (ADHD) is a condition that affects nearly ... early school years. Children with ADHD are known to ...
Cached Medicine News:
(Date:9/19/2014)... WHITEHOUSE STATION, N.J. , Sept. 19, 2014 Merck ... the United States and Canada , ... on Desafiando La Diabetes: Logra Tus Metas , an educational ... of their blood sugar -- a key treatment goal to help ... the United States are at a higher risk for ...
(Date:9/19/2014)... Five MinuteClinic walk-in medical clinics are opening inside select CVS/pharmacy stores ... opened in Memphis and Cordova ... in Springfield on September 24 and a ... open October 22.  MinuteClinic is the largest and fastest growing provider ... . The Memphis -area clinics join ...
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
Breaking Medicine Technology:Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3
... June 27 /CNW/ -,Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; ... a clinical trial,comparing CellCept (oral mycophenolate mofetil, MMF) ... of care, for,inducing treatment response in the induction ... rates were similar in both arms, the trial ...
... WIRE)--Jun 27, 2007 - PrimeCell(TM),Therapeutics LLC (http://www.primecelltherapeutics.com) ... pre-clinical,studies for a clinical trial to assess ... bone marrow stem cells into,spinal cord injury ... preliminary report at the 13th,Annual Meeting of ...
Cached Medicine Technology:Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 2Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 3Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 4Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 5Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 6Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 7Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 8Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for,Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical,Study 2
... Heavy Duty is a pressure relief mattress overlay ... specifically to the BariKare® Bed., ,INDICATIONS , ... lbs., Large patients at risk or suffering from ... mattress that would benefit from a pressure relief ...
... bariatric bed system which helps provide comfort ... care setting, ,INDICATIONS: ,Patients weighing up ... 2) ,Healthcare frame accommodating one or two ... ,CONTRAINDICATION: ,Total weight in excess of ...
... The BariMaxx™ is a full-featured healthcare ... environment for the care and management of ... up to 1000 lbs. ,Large patients at ... weight in excess of 1000 lbs. (including ...
EC+ Extra Care Bariatric Bed...
Medicine Products: