Navigation Links
Scientists Find New Key to Lupus
Date:10/19/2009

Molecule identified in lab mice may cause autoimmune disease

MONDAY, Oct. 19 (HealthDay News) -- Researchers say they've gained new understanding of how lupus develops in mice, a finding that could help future treatments for the autoimmune disease.

An estimated 1.5 million to 2 million people in the United States suffer from lupus, a disorder in which the body's defenses turn inward. The condition can cause symptoms similar to those of arthritis and rheumatic diseases.

At issue is the immune system's ability to take out the trash -- to get rid of cells that don't have long to live. "Just like in mice, in humans, if you don't clear the dying cells, then that predisposes you to lupus," said Lata Mukundan, a Stanford University School of Medicine researcher and co-author of a study published online Oct. 18 in the journal Nature Medicine.

"If you look at patients with lupus, they have an inability to clear those dead cells," Mukundan said in a statement.

The study authors report that they gained insight into how immune-system cells detect which other cells are dying in order to dispose of them. They looked at human and mouse cells outside the body and in genetically engineered mice.

The researchers suspected that a molecule known as PPAR-delta was crucial to the process. "We wanted to know, if you took a mouse and only deleted PPAR-delta from its macrophages, is that sufficient to cause an autoimmune disease?" asked Dr. Ajay Chawla, assistant professor of endocrinology and co-author of the study, in a statement. "Apparently it is," he said.

The researchers say currently existing drugs activate the molecule in question. Perhaps, they say, the drugs could treat lupus.

More information

Learn more about lupus from the National Institutes of Health.




'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Health care is only part of the puzzle: Social scientists analyze societys health and success
2. Scientists Provide First Map of Complete Human Epigenome
3. New Professional Network Brings Chinese Scientists and Researchers into International Community
4. Hutchinson Center scientists net $16.7 million for stem cell research
5. USC neuroscientists awarded $9 million to map gene expression during human brain development
6. Duke/Singapore scientists find new way to classify gastric cancers
7. Scripps research scientists find missing puzzle piece of powerful DNA repair complex
8. Scientists decipher missing piece of first-responder DNA repair machine
9. University of Louisville neuroscientists hope to get people walking again
10. Oldest Skeleton in Human Family Tree Surprises Scientists
11. Scientists find obesity alone does not cause arthritis in animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... The Truth about Six Pack Abs is a ... users some shocking foods that can burn belly fat, unique ... as well as some motivation secrets for successful fitness. , ... one unique trick that can help users reduce junk-food cravings. ... people might think, cardio exercise routines are not the best ...
(Date:8/30/2014)... Information supplied by insurance companies has ... prices to consumers in 2014. A group of ratess ... using the open system for adults at http://quotespros.com/life-insurance.html ... use this year can help the average person to ... and not from medical histories. The finder tool works ...
(Date:8/30/2014)... Denver, Colorado (PRWEB) August 30, 2014 ... a method that keeps anxiety and panic attacks under ... "Panic Away" program review describes this new ... help sufferers control panic attacks and overcome general anxiety ... popular and successful is the fact that it can ...
(Date:8/30/2014)... New York, NY (PRWEB) August 30, 2014 ... for authentic U.S. Open Tennis Championship tickets ... their customer appreciation promo/coupon code US-OPEN-2014 for all day ... (GA) seats and group sales for this prestigious Grand ... schedule is below: , 8/30/14 , US Open Tennis ...
(Date:8/30/2014)... VA (PRWEB) August 30, 2014 Seniors Guide, ... articles recently that focus on Alzheimer’s Disease, Dementia, and ... revealed to the public of being diagnosed with the Alzheimer’s, ... latest movie, “I’ll Be Me”. The movie, out on ... while focusing on his diagnosis of the disease – which ...
Breaking Medicine News(10 mins):Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2Health News:Term Life Insurance Rates Now Found Nationally by New Insurer Finder Tool 2Health News:Panic Away Review Reveals New Natural Remedy for Anxiety Patients 2Health News:US Open Tennis Tickets: Ticket Down Slashes Ticket Prices for Labor Day Weekend Sessions and More 2Health News:US Open Tennis Tickets: Ticket Down Slashes Ticket Prices for Labor Day Weekend Sessions and More 3Health News:US Open Tennis Tickets: Ticket Down Slashes Ticket Prices for Labor Day Weekend Sessions and More 4Health News:US Open Tennis Tickets: Ticket Down Slashes Ticket Prices for Labor Day Weekend Sessions and More 5Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2
... in a gene called FGFR2 could accelerate the development ... uterine cancer. Researchers at Washington University School of Medicine ... (TGen); the Wellcome Trust Sanger Institute, which is part ... Medicine reported the findings in the May 21, 2007, ...
... new study has shown the severe repercussions of high-fat food combined ... on liver and other vital organs. ,The study ... at Saint Louis University. ,As part of the study, ... a diet that was 40 percent fat and replete with high ...
... A nationwide study has been launched in US to determine ... and lorazepam, is more effective. ,Childhood seizures ... seizures can lead to brain damage or even death ... two drugs currently prescribed to tackle emergency situations - ...
... research has found that parents can foresee their children's exam ... ,The University of Bath study suggests that English and ... , ,Students with longer ring fingers are more likely ... ring fingers are said to be more proficient at literacy. ...
... demand. Two experts in this weeks BMJ debate whether presumed ... is evidence to the contrary is the answer. ... organ donation, yet only 23% have registered their wish to ... the British Medical Association. ,Research indicates that countries ...
... is widely consumed beverage and is regularly investigated and ... cancer to heart disease. Among its complex effects on ... linked to lower insulin and uric acid levels on ... suggest that coffee consumption may affect the risk of ...
Cached Medicine News:Health News:Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer 2Health News:Gene Discovery Lays Groundwork for Targeted Therapies for Endometrial Cancer 3Health News:High-fat and Sugary Diet Severely Damage Liver and Other Vital Organs 2Health News:Pediatric Seizure Study Underway in US to Decide Between Diazepam and Lorazepam 2Health News:Pediatric Seizure Study Underway in US to Decide Between Diazepam and Lorazepam 3Health News:Pediatric Seizure Study Underway in US to Decide Between Diazepam and Lorazepam 4Health News:Fingers of Kids can Predict Their Performance in Exams 2Health News:Is Presumed Consent the Answer to Organ Shortages? 2Health News:Four Cups of Coffee a Day may Cut Down the Risk of Gout 2Health News:Four Cups of Coffee a Day may Cut Down the Risk of Gout 3
(Date:8/29/2014)... 2014 Research and Markets  has announced the ... 2014" report to their offering. The ... of the largest segments of pharmaceuticals industry. The numbers of ... available therapies were unable to meet the market requirements. There ... CNS disorder, especially over the past two decades. The market ...
(Date:8/29/2014)... , Aug. 29, 2014 Does your doctor know ... 800 doctors have recommended marijuana to the over 112,000 currently ... But the majority of the other roughly 20,300+ active physicians ... very little about it – even though a poll in ... adults say they have tried it. "With ...
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4District Court Decision Received In Remodulin Patent Case 2
... 3 Glufosfamide and Phase 2 Glufosfamide Plus ... Gemcitabine Clinical Trials to be Presented, REDWOOD CITY, Calif., ... announced two presentations,regarding its oncology product candidate glufosfamide. The presentations,will ... held,September 23 to 27, 2007, at the International Conference Center ...
... First Hsp90 Inhibitor to Enter Registration Trials, HAYWARD, ... ) today announced that it has successfully,reached a binding ... the design of its TIME-1 clinical trial, a pivotal ... treatment for patients with,multiple myeloma. Through the FDA,s Special ...
Cached Medicine Technology:Threshold Pharmaceuticals Announces Two Presentations on Glufosfamide at the 2007 European Cancer Conference (ECCO) 2Threshold Pharmaceuticals Announces Two Presentations on Glufosfamide at the 2007 European Cancer Conference (ECCO) 3Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 2Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 3Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 4Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 5Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 6Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma 7
The workhorse electric system....
... Knife with BD Xstar Blade includes a ... the blade in prodedure and handling. ... a grind-less process for manufacturing surgical blades. ... and consistency. The arch style, single-bevel ...
... Safety Knife with BD Xstar Blade includes ... protects the blade in prodedure and handling. ... on a grind-less process for manufacturing surgical ... sharpness and consistency. The arch style, ...
... BD Safety Knife with BD Xstar Blade ... that protects the blade in prodedure and ... based on a grind-less process for manufacturing ... outstanding sharpness and consistency. The arch ...
Medicine Products: