Navigation Links
Scientists Find Molecular Similarities in Brains of Those With Autism
Date:5/25/2011

By Jenifer Goodwin
HealthDay Reporter

WEDNESDAY, May 25 (HealthDay News) -- The symptoms and severity of autism vary widely, but new research shows remarkable similarities at the molecular level in the brains of people with the disorder.

Researchers from Los Angeles, Toronto and London analyzed post-mortem brain tissue samples from 19 people with autism and 17 without.

In the healthy brains, researchers saw distinct differences in the gene expression in the frontal lobe vs. the temporal lobe of the cerebral cortex -- differences that help determine the structure and function of the two brain regions.

Specifically, between the frontal and temporal lobes in the healthy brains, more than 500 genes were expressed at different levels. Gene expression is the process by which a gene's DNA sequence is copied into RNA to produce proteins, which perform specific tasks within the cell.

But researchers didn't find those same patterns in autistic brains. Instead, researchers found only eight differences in the gene expression in the frontal and temporal lobes.

"In a healthy brain, the frontal and temporal lobes can be differentiated," said principal investigator Dr. Daniel Geschwind, a distinguished professor of neurology, psychiatry and human genetics at the David Geffen School of Medicine at UCLA. "But in autism we didn't see that. Instead, the frontal lobe closely resembles the temporal lobe."

Many of those regional differences in the cerebral cortex are established during fetal development, researchers added.

The study is published in the May 25 online issue of Nature.

Over the past decade, researchers have discovered lots of gene variants that seem to play a role in some cases of autism, but none of the mutations were present in a large percentage of people with the disorder.

Prior research has also implicated regions of the cerebral cortex, which is highly developed in humans,
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. NIH scientists identify most proteins made by parasitic worm
2. Heart scientists discover protein that may be 1 cause of heart failure
3. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
4. Scientists discover new drug target for squamous cell carcinoma
5. Queens scientists teaming up to cure premature baby blindness
6. Scientists design new anti-flu virus proteins using computational methods
7. Scientists use genetically altered virus to get tumors to tattle on themselves
8. Scientists Find MRSA Germ in Supermarket Meats
9. Weizmann Institute scientists show: How adversity dulls our perceptions
10. McMaster scientists find protein’s bad guy role in prostate cancer
11. UCLA scientists discover way to amp up power of killer T cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Molecular Similarities in Brains of Those With Autism 
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2
... News) -- Rheumatoid arthritis patients who believe in their ... -- are more likely to reach those objectives, researchers ... who achieve their physical activity goals have lower levels ... Researchers in the Netherlands conducted an initial assessment ...
... faculty researchers and clinicians with expertise in polypharmacy, ... geriatric researcher at a free conference examining Alzheimer,s ... Medicine and Nursing join with the Greater Kentucky ... to present "The Journey: Alzheimer,s Disease and Caregiving" ...
... 2011) Bone marrow transplantation with genetically modified cells ... study led by Dr. Vivek Rangnekar, associate director of ... University of Kentucky. Bone marrow, a spongy tissue ... including leukocytes, erythrocytes and platelets. In the cover story ...
... , WEDNESDAY, Aug. 24 (HealthDay News) -- High ... fatal abnormal heart rhythms and should no longer be ... said Wednesday. Doses of Celexa (citalopram hydrobromide) greater ... the electrical activity of the heart, which can lead ...
... Aug. 24 (HealthDay News) -- U.S. teens who use social networking ... drugs and alcohol than teens with little exposure to such media, ... youths from around the nation aged 12 to 17 and about ... of teens said they used social networking sites. Social network ...
... Ont., Aug 24, 2011 More than eight out of ... and elsewhere have at least one chronic health condition and ... who are "vulnerably housed"meaning they live in unsafe, unstable or ... the survey found. The underlying cause for these health ...
Cached Medicine News:Health News:UofL experts featured at free Alzheimer's disease conference Sept. 17 2Health News:Teen Drinking, Smoking Higher Among Facebook Users: Survey 2Health News:Teen Drinking, Smoking Higher Among Facebook Users: Survey 3Health News:Study: 85 percent of homeless people have chronic health conditions 2
(Date:1/23/2015)... ORLANDO, Fla. and DUBLIN , ... of the agreement with KRS Global Biotechnology, Inc. for the ... will be compounded for shipment in the United ... 503B FDA approved Outsourcing Facility capable of compounding naltrexone tablets ...
(Date:1/23/2015)... PHILADELPHIA , Jan. 23, 2015  Pete Rose, baseball,s all-time ... joint and arthritis pain reliever Myoflex, Ducere Pharma has announced. ... and we are excited to have him on board with ... . "He is a legendary player who is known across ...
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
Breaking Medicine Technology:Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4Pete Rose bets on Myoflex to relieve aches and pains 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... part of the brain first,affected by Alzheimers disease ... a risk gene for the disorder, a brain,imaging ... Mental,Health (NIMH), one of the National Institutes of ... structure in the lower middle,part of the brains ...
... 25, 2007 - Reata,Pharmaceuticals, Inc. today announced ... company's Synthetic Triterpenoid programs in,the May 2007 ... The article, "Triterpenoids and rexinoids as multifunctional,agents ... by researchers,and Reata scientific collaborators from the ...
Cached Medicine Technology:Cortex Area Thinner in Youth with Alzheimers-Related Gene 2Cortex Area Thinner in Youth with Alzheimers-Related Gene 3Cortex Area Thinner in Youth with Alzheimers-Related Gene 4Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 2Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 3Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 4
Detection of Lupus Anticoagulants. Freeze-dried hexagonal phase phos-phatidylethanolamine; normal plasma with heparin inhibitor; PTT-LS reagent of cephalin and particulate siliceous activator;all fre...
Colorimetric Assay of Protein C Activity by STA© Analyzers. Highly purified extract of Agkistrodon c. contortrix venom for specific activation of protein C, with an activator selected specially ...
Immuno-turbidimetric assay for Free Protein Sby STA© Analyzers. Suspension of microparticles coated with monoclonal antibodies to Free Protein S....
Substrate Plasma for Factor V Assay by STA© Analyzers. Freeze-dried human plasma, artificially depleted of factor V....
Medicine Products: