Navigation Links
Scientists Find Gene Differences in Nonsmokers With Lung Cancer
Date:11/12/2012

MONDAY, Nov. 12 (HealthDay News) -- Three genetic regions associated with increased lung cancer risk in Asian women who have never smoked have been identified by an international team of scientists.

They said their findings provide further proof that the risk of lung cancer among people who never smoked, especially Asian women, may be associated with specific genetic characteristics that distinguish it from lung cancer in smokers.

The researchers analyzed data from 14 studies that included a total of about 14,000 Asian women (6,600 with lung cancer and 7,500 without the disease). The team found that variations at three locations in the genome -- two on chromosome 6 and one on chromosome 10 -- were associated with lung cancer in Asian women who never smoked.

The discovery on chromosome 10 was especially important because it has not been found in previous research, according to the study published online Nov. 11 in the journal Nature Genetics.

"Our study provides strong evidence that common inherited genetic variants contribute to an increased risk of lung cancer among Asian women who have never smoked," study co-author Dr. Nathaniel Rothman, a senior investigator in the division of cancer epidemiology and genetics at the U.S. National Cancer Institute, said in an institute news release.

"These variants may also increase lung cancer risk associated with environmental factors, such as environmental tobacco smoke," he added.

The researchers did not find an association between lung cancer risk in Asian women who had never smoked and variations at a location on chromosome 15 that has been linked with lung cancer risk in smokers. This provides further proof that the genetic variation on chromosome 15 may be smoking related, the authors said in the news release.

The research team also found some evidence that Asian women with one of the newly identified genetic variants may be more vulnerable to the effects of secondhand smoke. But more research is needed to confirm this.

Lung cancer among people who have never smoked is the seventh leading cause of cancer death worldwide, according to the release. Historically, most lung cancer diagnosed among women in Eastern Asia has been among those who never smoked. The three genetic variations identified in this study have not been associated with lung cancer risk in other populations.

More information

The American Cancer Society has more about lung cancer.

-- Robert Preidt

SOURCE: U.S. National Cancer Institute, news release, Nov. 11, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists at IRB BARCELONA discover a key process that allows colon cancer to metastasize
2. Scientists uncover a new pathway that regulates information processing in the brain
3. 2 Scripps Research Institute scientists honored by American Chemical Society
4. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
5. Loyola names Junior and Senior Scientists of the Year
6. Scientists find Achilles’ heel of cancer cells
7. UC Davis scientists identify new target for lung cancer treatment
8. Scientists create endless supply of myelin-forming cells
9. Scientists decode software instructions of aggressive leukemia cells
10. Canadian scientists discover cause of high cholesterol
11. Scientists step up hunt for bacterial genes tied to Lyme disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Gene Differences in Nonsmokers With Lung Cancer
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: