Navigation Links
Scientists Find Gene Differences in Nonsmokers With Lung Cancer

MONDAY, Nov. 12 (HealthDay News) -- Three genetic regions associated with increased lung cancer risk in Asian women who have never smoked have been identified by an international team of scientists.

They said their findings provide further proof that the risk of lung cancer among people who never smoked, especially Asian women, may be associated with specific genetic characteristics that distinguish it from lung cancer in smokers.

The researchers analyzed data from 14 studies that included a total of about 14,000 Asian women (6,600 with lung cancer and 7,500 without the disease). The team found that variations at three locations in the genome -- two on chromosome 6 and one on chromosome 10 -- were associated with lung cancer in Asian women who never smoked.

The discovery on chromosome 10 was especially important because it has not been found in previous research, according to the study published online Nov. 11 in the journal Nature Genetics.

"Our study provides strong evidence that common inherited genetic variants contribute to an increased risk of lung cancer among Asian women who have never smoked," study co-author Dr. Nathaniel Rothman, a senior investigator in the division of cancer epidemiology and genetics at the U.S. National Cancer Institute, said in an institute news release.

"These variants may also increase lung cancer risk associated with environmental factors, such as environmental tobacco smoke," he added.

The researchers did not find an association between lung cancer risk in Asian women who had never smoked and variations at a location on chromosome 15 that has been linked with lung cancer risk in smokers. This provides further proof that the genetic variation on chromosome 15 may be smoking related, the authors said in the news release.

The research team also found some evidence that Asian women with one of the newly identified genetic variants may be more vulnerable to the effects of secondhand smoke. But more research is needed to confirm this.

Lung cancer among people who have never smoked is the seventh leading cause of cancer death worldwide, according to the release. Historically, most lung cancer diagnosed among women in Eastern Asia has been among those who never smoked. The three genetic variations identified in this study have not been associated with lung cancer risk in other populations.

More information

The American Cancer Society has more about lung cancer.

-- Robert Preidt

SOURCE: U.S. National Cancer Institute, news release, Nov. 11, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists at IRB BARCELONA discover a key process that allows colon cancer to metastasize
2. Scientists uncover a new pathway that regulates information processing in the brain
3. 2 Scripps Research Institute scientists honored by American Chemical Society
4. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
5. Loyola names Junior and Senior Scientists of the Year
6. Scientists find Achilles’ heel of cancer cells
7. UC Davis scientists identify new target for lung cancer treatment
8. Scientists create endless supply of myelin-forming cells
9. Scientists decode software instructions of aggressive leukemia cells
10. Canadian scientists discover cause of high cholesterol
11. Scientists step up hunt for bacterial genes tied to Lyme disease
Post Your Comments:
Related Image:
Scientists Find Gene Differences in Nonsmokers With Lung Cancer
(Date:11/25/2015)... Canadian, OK (PRWEB) , ... November 25, 2015 , ... ... and International training center for the Narconon network, announced the release of a new ... Since 1966 the Narconon organization has been working with drug- and alcohol-addicted individuals with ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 23rd 2015 ... Tri Lite’s personal heating products business. Cozy Products explains what this means for ... fit in well with the Cozy Products business model: to sell personal heaters that ...
(Date:11/25/2015)... Calif. (PRWEB) , ... November 25, 2015 , ... Beddit® ... and Beddit Classic sleep tracking systems. The new app features a more intuitive SleepScore™ ... and understand how well you slept. The SleepScore is created by a proprietary algorithm. ...
(Date:11/25/2015)... , ... November 25, 2015 , ... “While riding the ... inventor, from Bronx, N.Y. “I thought there had to be a convenient and comfortable ... PROTECTOR. , The PROTECTOR enables disabled individuals to safely travel during cold or inclement ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for ... The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout 2016 ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Japanese therapeutic drug monitoring market, including ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
(Date:11/26/2015)... --> ... att använda SyMRI för att hitta optimal ... med multipel skleros (MS) eller hjärntumörmetastaser och ... för att kunna använda SyMRI Research Edition ... kan man generera flera konstrastbilder från en ...
Breaking Medicine Technology: