Navigation Links
Scientists Find Gene Differences in Nonsmokers With Lung Cancer
Date:11/12/2012

MONDAY, Nov. 12 (HealthDay News) -- Three genetic regions associated with increased lung cancer risk in Asian women who have never smoked have been identified by an international team of scientists.

They said their findings provide further proof that the risk of lung cancer among people who never smoked, especially Asian women, may be associated with specific genetic characteristics that distinguish it from lung cancer in smokers.

The researchers analyzed data from 14 studies that included a total of about 14,000 Asian women (6,600 with lung cancer and 7,500 without the disease). The team found that variations at three locations in the genome -- two on chromosome 6 and one on chromosome 10 -- were associated with lung cancer in Asian women who never smoked.

The discovery on chromosome 10 was especially important because it has not been found in previous research, according to the study published online Nov. 11 in the journal Nature Genetics.

"Our study provides strong evidence that common inherited genetic variants contribute to an increased risk of lung cancer among Asian women who have never smoked," study co-author Dr. Nathaniel Rothman, a senior investigator in the division of cancer epidemiology and genetics at the U.S. National Cancer Institute, said in an institute news release.

"These variants may also increase lung cancer risk associated with environmental factors, such as environmental tobacco smoke," he added.

The researchers did not find an association between lung cancer risk in Asian women who had never smoked and variations at a location on chromosome 15 that has been linked with lung cancer risk in smokers. This provides further proof that the genetic variation on chromosome 15 may be smoking related, the authors said in the news release.

The research team also found some evidence that Asian women with one of the newly identified genetic variants may be more vulnerable to the effects of secondhand smoke. But more research is needed to confirm this.

Lung cancer among people who have never smoked is the seventh leading cause of cancer death worldwide, according to the release. Historically, most lung cancer diagnosed among women in Eastern Asia has been among those who never smoked. The three genetic variations identified in this study have not been associated with lung cancer risk in other populations.

More information

The American Cancer Society has more about lung cancer.

-- Robert Preidt

SOURCE: U.S. National Cancer Institute, news release, Nov. 11, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists at IRB BARCELONA discover a key process that allows colon cancer to metastasize
2. Scientists uncover a new pathway that regulates information processing in the brain
3. 2 Scripps Research Institute scientists honored by American Chemical Society
4. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
5. Loyola names Junior and Senior Scientists of the Year
6. Scientists find Achilles’ heel of cancer cells
7. UC Davis scientists identify new target for lung cancer treatment
8. Scientists create endless supply of myelin-forming cells
9. Scientists decode software instructions of aggressive leukemia cells
10. Canadian scientists discover cause of high cholesterol
11. Scientists step up hunt for bacterial genes tied to Lyme disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Gene Differences in Nonsmokers With Lung Cancer
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: