Navigation Links
Scientists Find Clues to How the Body Fights Off HIV
Date:4/5/2010

Research on antibodies may aid vaccine development

MONDAY, April 5 (HealthDay News) -- Researchers report that they've gained more insight into how the body fights off HIV, a finding that offers a possible new avenue toward a vaccine against the virus, which causes AIDS.

At the moment, there's no way to know whether the research will help scientists develop a vaccine. HIV remains an extremely stubborn enemy.

Still, the findings do give scientists an idea of how to prepare the body to meet the threat of HIV, "a possible way that one could think about the kinds of response you'd want to have on hand before a virus shows up," said study author Dr. M. Anthony Moody, chief medical officer at Duke University's Human Vaccine Institute.

The findings are reported online April 5 in the Journal of Experimental Medicine.

The study examines antibodies, the foot soldiers of the immune system that gather to fight off invaders. The researchers found four kinds of antibodies that appear to create a barrier that prevents HIV from getting into a kind of door in cells.

That door, known as a receptor, is an entry point for HIV in the vast majority of cases.

The four antibodies work differently than their counterparts because they focus on creating a barricade to protect the cells instead of doing direct battle with the virus cells, Moody said.

It's not clear if having more of these antibodies would help people do a better job of fighting off HIV. There's definite room for improvement in that area, Moody said.

"One of the fundamental problems that research in HIV has faced is that when people become infected, they don't typically mount an antibody response that's very effective at controlling a response early on," Moody said. "The response to the virus is much slower, and it's delayed and comes in stages. The kinds of antibodies that are produced do appear to have an effect, but the virus always seems to stay one step ahead."

By contrast, the body has a more effective antibody response to viruses such as influenza, he said.

The next step is to "understand even more deeply what's going on," Moody said. Another step would be to consider whether to test the antibodies in animals and people to see whether they boost their immune systems, he said.

Rowena Johnston, vice president of research with amfAR, the Foundation for AIDS Research in New York City, said the research reflects a feeling in the HIV vaccine research field that "what they need to do is go back to the drawing board."

The challenge, she said, is that many steps would be involved in getting the antibodies to protect cells against HIV. "The more steps you introduce into it, the more things that can go wrong," she said.

The research does provide more information about how the process works, she said, "but it doesn't mean the next step is voila, we have a vaccine."

More information

The U.S. Vaccine Research Center has more on research into an HIV vaccine.



SOURCES: M. Anthony Moody, M.D., chief medical officer, Human Vaccine Institute, Duke University School of Medicine, Durham, N.C.; Rowena Johnston, Ph.D., vice president, research, amfAR, The Foundation for AIDS Research, New York City; April 5, 2010, Journal of Experimental Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Caltech scientists uncover structure of key protein in common HIV subgroup
2. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
3. Scientists Tweak Subjects Brains to Alter Their Moral Choices
4. Scientists in hot pursuit of first new drug for global killer in 50 years
5. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
6. Anti-obesity drugs unlikely to provide lasting benefit according to scientists
7. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
8. Scientists Find Stem Cells in Hair That Can Become Skin
9. MRC scientists announce advance in understanding bodys natural defenses
10. Scientists identify microRNA as possible cause of chemotherapy resistance
11. Scientists Find Key to Hormone-Resistant Prostate Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... ... , ... The American College of Medical Informatics (ACMI) will present the 2017 ... Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is ... pioneer in the field of medical informatics, this prestigious award is presented to an ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
Breaking Medicine Technology: