Navigation Links
Scientists Find Clues to How the Body Fights Off HIV
Date:4/5/2010

Research on antibodies may aid vaccine development

MONDAY, April 5 (HealthDay News) -- Researchers report that they've gained more insight into how the body fights off HIV, a finding that offers a possible new avenue toward a vaccine against the virus, which causes AIDS.

At the moment, there's no way to know whether the research will help scientists develop a vaccine. HIV remains an extremely stubborn enemy.

Still, the findings do give scientists an idea of how to prepare the body to meet the threat of HIV, "a possible way that one could think about the kinds of response you'd want to have on hand before a virus shows up," said study author Dr. M. Anthony Moody, chief medical officer at Duke University's Human Vaccine Institute.

The findings are reported online April 5 in the Journal of Experimental Medicine.

The study examines antibodies, the foot soldiers of the immune system that gather to fight off invaders. The researchers found four kinds of antibodies that appear to create a barrier that prevents HIV from getting into a kind of door in cells.

That door, known as a receptor, is an entry point for HIV in the vast majority of cases.

The four antibodies work differently than their counterparts because they focus on creating a barricade to protect the cells instead of doing direct battle with the virus cells, Moody said.

It's not clear if having more of these antibodies would help people do a better job of fighting off HIV. There's definite room for improvement in that area, Moody said.

"One of the fundamental problems that research in HIV has faced is that when people become infected, they don't typically mount an antibody response that's very effective at controlling a response early on," Moody said. "The response to the virus is much slower, and it's delayed and comes in stages. The kinds of antibodies that are produced do appear to have an effect, but the virus always seems to stay one step ahead."

By contrast, the body has a more effective antibody response to viruses such as influenza, he said.

The next step is to "understand even more deeply what's going on," Moody said. Another step would be to consider whether to test the antibodies in animals and people to see whether they boost their immune systems, he said.

Rowena Johnston, vice president of research with amfAR, the Foundation for AIDS Research in New York City, said the research reflects a feeling in the HIV vaccine research field that "what they need to do is go back to the drawing board."

The challenge, she said, is that many steps would be involved in getting the antibodies to protect cells against HIV. "The more steps you introduce into it, the more things that can go wrong," she said.

The research does provide more information about how the process works, she said, "but it doesn't mean the next step is voila, we have a vaccine."

More information

The U.S. Vaccine Research Center has more on research into an HIV vaccine.



SOURCES: M. Anthony Moody, M.D., chief medical officer, Human Vaccine Institute, Duke University School of Medicine, Durham, N.C.; Rowena Johnston, Ph.D., vice president, research, amfAR, The Foundation for AIDS Research, New York City; April 5, 2010, Journal of Experimental Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Caltech scientists uncover structure of key protein in common HIV subgroup
2. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
3. Scientists Tweak Subjects Brains to Alter Their Moral Choices
4. Scientists in hot pursuit of first new drug for global killer in 50 years
5. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
6. Anti-obesity drugs unlikely to provide lasting benefit according to scientists
7. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
8. Scientists Find Stem Cells in Hair That Can Become Skin
9. MRC scientists announce advance in understanding bodys natural defenses
10. Scientists identify microRNA as possible cause of chemotherapy resistance
11. Scientists Find Key to Hormone-Resistant Prostate Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology: