Navigation Links
Scientists Find Clues to How the Body Fights Off HIV
Date:4/5/2010

Research on antibodies may aid vaccine development

MONDAY, April 5 (HealthDay News) -- Researchers report that they've gained more insight into how the body fights off HIV, a finding that offers a possible new avenue toward a vaccine against the virus, which causes AIDS.

At the moment, there's no way to know whether the research will help scientists develop a vaccine. HIV remains an extremely stubborn enemy.

Still, the findings do give scientists an idea of how to prepare the body to meet the threat of HIV, "a possible way that one could think about the kinds of response you'd want to have on hand before a virus shows up," said study author Dr. M. Anthony Moody, chief medical officer at Duke University's Human Vaccine Institute.

The findings are reported online April 5 in the Journal of Experimental Medicine.

The study examines antibodies, the foot soldiers of the immune system that gather to fight off invaders. The researchers found four kinds of antibodies that appear to create a barrier that prevents HIV from getting into a kind of door in cells.

That door, known as a receptor, is an entry point for HIV in the vast majority of cases.

The four antibodies work differently than their counterparts because they focus on creating a barricade to protect the cells instead of doing direct battle with the virus cells, Moody said.

It's not clear if having more of these antibodies would help people do a better job of fighting off HIV. There's definite room for improvement in that area, Moody said.

"One of the fundamental problems that research in HIV has faced is that when people become infected, they don't typically mount an antibody response that's very effective at controlling a response early on," Moody said. "The response to the virus is much slower, and it's delayed and comes in stages. The kinds of antibodies that are produced do appear to have an effect, but the virus always seems to stay one step ahead."

By contrast, the body has a more effective antibody response to viruses such as influenza, he said.

The next step is to "understand even more deeply what's going on," Moody said. Another step would be to consider whether to test the antibodies in animals and people to see whether they boost their immune systems, he said.

Rowena Johnston, vice president of research with amfAR, the Foundation for AIDS Research in New York City, said the research reflects a feeling in the HIV vaccine research field that "what they need to do is go back to the drawing board."

The challenge, she said, is that many steps would be involved in getting the antibodies to protect cells against HIV. "The more steps you introduce into it, the more things that can go wrong," she said.

The research does provide more information about how the process works, she said, "but it doesn't mean the next step is voila, we have a vaccine."

More information

The U.S. Vaccine Research Center has more on research into an HIV vaccine.



SOURCES: M. Anthony Moody, M.D., chief medical officer, Human Vaccine Institute, Duke University School of Medicine, Durham, N.C.; Rowena Johnston, Ph.D., vice president, research, amfAR, The Foundation for AIDS Research, New York City; April 5, 2010, Journal of Experimental Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Caltech scientists uncover structure of key protein in common HIV subgroup
2. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
3. Scientists Tweak Subjects Brains to Alter Their Moral Choices
4. Scientists in hot pursuit of first new drug for global killer in 50 years
5. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
6. Anti-obesity drugs unlikely to provide lasting benefit according to scientists
7. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
8. Scientists Find Stem Cells in Hair That Can Become Skin
9. MRC scientists announce advance in understanding bodys natural defenses
10. Scientists identify microRNA as possible cause of chemotherapy resistance
11. Scientists Find Key to Hormone-Resistant Prostate Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... patient payment industry today announced its strategic partnership with Connance, a healthcare ... , The two companies’ proven, proprietary technology combine to provide health systems, ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: