Navigation Links
Scientists Find Clue to Dangerous Side Effect of MS Drug
Date:9/9/2009

Tysabri appears to awaken dormant, common virus that crosses over into brain

WEDNESDAY, Sept. 9 (HealthDay News) -- Scientists may have discovered part of the reason why Tysabri, a drug used to treat multiple sclerosis, may lead to the development of a rare but potentially deadly brain disease in some patients.

The drug seems to rouse the typically dormant JC virus from its slumber, allowing it to cross into the brain.

Although this finding may lead to a way of predicting who is at risk for the brain infection -- called progressive multifocal leukoencephalopathy (PML) -- at this point, the implications are still unclear.

"We don't know what this means until we find out over time whether or not people actually do get PML," said Patricia O'Looney, vice president of biomedical research at the National Multiple Sclerosis Society in New York City. "But it certainly is exploring a key question."

The study authors also warned against coming to premature conclusions.

"We don't advocate a change in management [of the disease] at this point because the clinical relevance of these findings is still unknown," said Dr. Igor J. Koralnik, senior author of a paper appearing in the Sept. 10 issue of the New England Journal of Medicine. "But it should spur further research."

Natalizumab (Tysabri) first received U.S. Food and Drug Administration approval in November 2004, only to be pulled from the market three months later after several patients in clinical trials developed the rare but deadly viral infection.

According to the study authors, as of July 24, 2009, 13 patients with multiple sclerosis taking Tysabri are known to have developed PML, along with one patient with Crohn's disease (Tysabri was approved to treat Crohn's in early 2008).

The JC virus is present yet dormant in about 90 percent of people. It can reactivate in people with AIDS or otherwise compromised immun
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Clue to Dangerous Side Effect of MS Drug
(Date:4/19/2015)... Indiana (PRWEB) April 19, 2015 ... statewide Network Service Provider, announces a major bandwidth ... (AdamsWells) in Bluffton, IN. Craigville Telephone Company, ... has expanded service on IFN’s protected 10 Gigabit ... Zehner, IFN’s Vice President of Sales and Marketing, ...
(Date:4/18/2015)... CA (PRWEB) April 19, 2015 For some ... will proudly display for the rest of their lives, as ... obtaining them and put in a great amount of thought ... a whim, they have outgrown them or simply want them ... of people regret their tattoo, and in 2012-13 there was ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post ... caused by a car accident. , Car ... vehicle. A policy can pay for car repairs and ... always carry appropriate coverage when they are driving. ... with several important riders that offer extra coverage options. ...
(Date:4/18/2015)... 18, 2015 "I recognized the need ... healthcare facilities," said an inventor from Cincinnati, Ohio. "This ... , He developed the Slyde Door to offer an ... healthcare facilities. It provides convenient storage space for an ... stretchers available for patients. , This offers added ...
(Date:4/18/2015)... Insuranceautoquote.info has released a new blog post explaining how ... , Clients can review important auto insurance quotes online, ... important advantages for clients who need affordable financial security ... have coverage for their vehicles can purchase a policy ... Many agencies offer important discounts and drivers can learn ...
Breaking Medicine News(10 mins):Health News:AdamsWells Internet Telecom TV Expands Bandwidth via Indiana Fiber Network, LLC 2Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2
... to reduce transmission from mother to child, experts say ... HIV infection in infants are significantly higher among blacks ... to reduce the disparity, a new government report says. ... overall, among black babies, the rate of perinatal HIV ...
... , SACRAMENTO, Calif. , Feb. 4 ... CEO and Meg Heim, RN , Vice President of Marketing ... Force Committee on behalf of the Governor of California , ... California Department of Chronic Disease and Injury Prevention (CDPH).  The committee ...
... , ATLANTA , Feb. 4 ... Financial Management Association (HFMA) performed a rigorous assessment of ... by Surgical Information Systems, and determined that it meets ... the areas of effectiveness, quality and usability, price, value, ...
... , HAMILTON, Bermuda , ... ("XL" or the "Company") today announced that Chief Executive,Officer Michael S. ... 2010 at the Mandarin Oriental Hotel in Miami, Florida ,on ... A live webcast of Mr. McGavick,s presentation will ...
... , , EDF Testifies 20 Million+ Residents in South ... Calif. , Feb. 4 Environmental Defense Fund ... Standard (NAAQS) for ozone pollution from 75 to 60 parts ... reduce asthma cases 50-fold, according to analyses by the Environmental Protection ...
... (Feb. 4, 2010) Patients with mild gallstone pancreatitis usually ... symptoms to subside, before undergoing surgery to remedy the condition. ... Institute (LA BioMed) indicates patients may no longer have to ... sooner. The study, slated for publication in the ...
Cached Medicine News:Health News:Black and Hispanic Infants Much More Likely to Have HIV 2Health News:BioMedix Vascular Solutions, Inc. Invited to Participate in the California P.A.D. Task Force Committee 2Health News:SIS Rules-Based Charging Solution Successfully Peer Reviewed by HFMA for Third Consecutive Year 2Health News:SIS Rules-Based Charging Solution Successfully Peer Reviewed by HFMA for Third Consecutive Year 3Health News:XL Capital Ltd to Present at Credit Suisse Financial Services Forum on February 11, 2010 2Health News:Stronger Ozone Standard Could Dramatically Reduce Asthma, Premature Deaths 2Health News:Stronger Ozone Standard Could Dramatically Reduce Asthma, Premature Deaths 3Health News:Patients with mild gallstone pancreatitis can undergo surgery sooner, shortening hospital stays 2
(Date:4/17/2015)... , April 17, 2015  Over the next five years, ... to grow, with ArcView predicting that 14 more states will ... marijuana. The U.S. market for legal cannabis grew 74 percent ... 2013. Analysts project the market could grow more than fourfold ... states soften their stance on marijuana. Cannabiz Mobile ...
(Date:4/17/2015)... 16, 2015 Research and Markets ( ... "Corporate Reputation of Pharma in 2014 - a Perspective ... to their offering. This independent study, funded ... groups with an interest in diabetes on the corporate ... pharma industry as a whole) in 2014. The results ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. For the ... on the corporate reputation of the pharmaceutical industry held ... with the views of patient organisations representing all therapy ...
Breaking Medicine Technology:Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3
... CVS Caremark reiterated the company,s support that the U.S. ... approve biogeneric drugs under the Affordable Care Act. The ... Reid, testified before the FDA today during a public ... for biosimilar and interchangeable biological products held at the ...
... 2010 Spectros Corporation presented new clinical results ... Tissue Oximeter at the San Diego Convention Center ... presented during poster sessions entitled "Experimental Circulation: Ischemia ... the American Society of Anesthesiologists (ASA 2010) on ...
Cached Medicine Technology:CVS Caremark Reiterates Support for FDA Implementation of Approval Pathway for Biogeneric Drugs 2Spectros Presents New Clinical Studies Using T-Stat VLS Tissue Oximeter at Anesthesiology 2010 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: