Navigation Links
Scientists Find Cancer Culprits in Cigarette Smoke
Date:2/28/2008

Hydrogen peroxide and other oxidants cause lung cells to become malignant

THURSDAY, Feb. 28 (HealthDay News) -- It's long been known that smoking causes lung cancer, but a new study is the first to show that the hydrogen peroxide in cigarette smoke is what actually causes healthy lung cells to turn cancerous.

Researchers from the University of California, Davis, said their findings may help lead to new treatments for lung cancer and may help the tobacco industry develop "safer" cigarettes by eliminating such substances in the smoke.

"With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets," senior author Tzipora Goldkorn said in a prepared statement.

In this laboratory study, the researchers exposed different sets of human lung cells to cigarette smoke or hydrogen peroxide and then incubated the cells for one to two days. The cells were then compared to unexposed airway cells. The cells exposed to cigarette smoke and those exposed to hydrogen peroxide showed the same molecular signatures of cancer development. The unexposed cells showed no such changes.

The findings are published in the March issue of The FASEB Journal, published by the Federation of American Societies for Experimental Biology.

Guns kill, bombs kill and cigarettes kill," Dr. Gerald Weissmann, editor-in-chief of The FASEB Journal, said in a prepared statement. "While biologists can't do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pinpoint new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in."

Cigarette smoking, which causes more than 400,000 deaths a year in the United States (about one in five of all deaths) is the leading preventable cause of premature death in the country, according to the U.S. Centers for Disease Control and Prevention. Smoking causes 90 percent of all lung cancer deaths in men and about 80 percent of lung cancer deaths in women.

Tobacco smoke contains more than 4,000 chemical compounds, including 43 that are know to cause cancer, according to a U.S. Surgeon General report released in 2000.

More information

The U.S. National Cancer Institute has more about smoking and cancer.



-- Robert Preidt



SOURCE: Federation of American Societies for Experimental Biology, news release, Feb. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
2. Scripps research scientists devise approach that stops HIV at earliest stage of infection
3. Scientists look at syringe assembly in plague bacteria
4. Scientists identify proteins that help bacteria put up a fight
5. CSHL scientists discover new details of a gene-regulatory network governing metabolism
6. Scientists make first map of emerging-disease hotpsots
7. Scientists shed light on long-distance signaling in developing neurons
8. Scientists explore consciousness
9. Scientists using laser light to detect potential diseases via breath samples, says new study
10. Scientists move towards stem cell therapy trials to mend shattered bones
11. U-M scientists develop tool to probe role of oxidative stress in aging, disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Cancer Culprits in Cigarette Smoke
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... More than ... so it is not surprising that bariatric surgery has received increased attention in recent ... explains. Of course, when it comes to weight loss, most people are familiar with ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Two director-level employees ... YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen ... For this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... An ... returns for a third time to shed lights on the variety of topics detailing ... inspirational stories, “Nurse Appreciation” tackles why this career has gone from being in a ...
(Date:5/27/2016)... ... May 27, 2016 , ... This campaign aims to provide a path to ... society can control and change. , As nearly 795,000 Americans suffering from a new ... United States. Plus, with an estimated 129,000 of these people dying from stroke, it’s ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response to ... who are unaware of the plight of aphasia. In collaboration with the American ... Awareness” campaign. , The link between stroke and aphasia is relatively unknown, but ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... LONDON , May 30, 2016 ... to eliminate viral hepatitis by 2030. At the 69 th ... first ever Global Viral Hepatitis Strategy, signalling the greatest global ... sets a goal of eliminating hepatitis B and C by ... which, if reached, will reduce annual deaths by 65% and ...
(Date:5/30/2016)... Eye expert s advise ... before leaving hospital to ... Eye Hospital Dubai, the first overseas branch of the world-renowned Moorfields ... babies as a special concern in the region when it comes ... prematurity (ROP). ROP is a potentially blinding condition that affects premature ...
(Date:5/27/2016)... May 27, 2016 According to ... hypertension is driving ambulatory blood pressure monitoring system market ... and their ability to respond to different pressure rates, ... can lead to various cardiovascular disorders such as heart ... These diseases are growing in prevalence each year. WHO ...
Breaking Medicine Technology: