Navigation Links
Scientists Find Cancer Culprits in Cigarette Smoke
Date:2/28/2008

Hydrogen peroxide and other oxidants cause lung cells to become malignant

THURSDAY, Feb. 28 (HealthDay News) -- It's long been known that smoking causes lung cancer, but a new study is the first to show that the hydrogen peroxide in cigarette smoke is what actually causes healthy lung cells to turn cancerous.

Researchers from the University of California, Davis, said their findings may help lead to new treatments for lung cancer and may help the tobacco industry develop "safer" cigarettes by eliminating such substances in the smoke.

"With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets," senior author Tzipora Goldkorn said in a prepared statement.

In this laboratory study, the researchers exposed different sets of human lung cells to cigarette smoke or hydrogen peroxide and then incubated the cells for one to two days. The cells were then compared to unexposed airway cells. The cells exposed to cigarette smoke and those exposed to hydrogen peroxide showed the same molecular signatures of cancer development. The unexposed cells showed no such changes.

The findings are published in the March issue of The FASEB Journal, published by the Federation of American Societies for Experimental Biology.

Guns kill, bombs kill and cigarettes kill," Dr. Gerald Weissmann, editor-in-chief of The FASEB Journal, said in a prepared statement. "While biologists can't do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pinpoint new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in."

Cigarette smoking, which causes more than 400,000 deaths a year in the United States (about one in five of all deaths) is the leading preventable cause of premature death in the country, according to the U.S. Centers for Disease Control and Prevention. Smoking causes 90 percent of all lung cancer deaths in men and about 80 percent of lung cancer deaths in women.

Tobacco smoke contains more than 4,000 chemical compounds, including 43 that are know to cause cancer, according to a U.S. Surgeon General report released in 2000.

More information

The U.S. National Cancer Institute has more about smoking and cancer.



-- Robert Preidt



SOURCE: Federation of American Societies for Experimental Biology, news release, Feb. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
2. Scripps research scientists devise approach that stops HIV at earliest stage of infection
3. Scientists look at syringe assembly in plague bacteria
4. Scientists identify proteins that help bacteria put up a fight
5. CSHL scientists discover new details of a gene-regulatory network governing metabolism
6. Scientists make first map of emerging-disease hotpsots
7. Scientists shed light on long-distance signaling in developing neurons
8. Scientists explore consciousness
9. Scientists using laser light to detect potential diseases via breath samples, says new study
10. Scientists move towards stem cell therapy trials to mend shattered bones
11. U-M scientists develop tool to probe role of oxidative stress in aging, disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Cancer Culprits in Cigarette Smoke
(Date:12/2/2016)... ... 02, 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover ... he was inspired to practice medicine at an early age by his father, who ... making diagnoses and prescribing medicine,” he states. “It is about building relationships with people; ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Health" in USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized ... fulfilling lives. “We are prolonging life 6 years in the last 3 decades,” ...
(Date:12/2/2016)... ... , ... Rijuven Corp launches rejiva ( http://www.rejiva.com ), a unique wearable technology ... health technology on the market can deliver all that rejiva can. , “Rejiva promotes ... their health than the usual heart rate and steps taken”, adds Evens Augustin, CEO ...
(Date:12/2/2016)... PA (PRWEB) , ... December 02, 2016 , ... ... and pharmaceutical organizations to build intelligent, connected applications, was named the best Sales ... , The winner announcement was made today by the Software & Information ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the ... while brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that there ... this handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... In the first ever attempt to include ... from C. sativa, the Hebrew University in Jerusalem, the ... II , the Universita` del Piemonte Orientale and Phytoplant ... and unified inventory of phytocannabinoids of different botanical origin. ... remarkable chemical and structural diversity of phytocannabinoids. As a ...
(Date:12/2/2016)... -- Maxor National Pharmacy Services, LLC ("Maxor"), today announced that it ... combination of Texas -based Maxor Specialty / ... together both company,s clinical expertise and high-touch patient service models ... pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... December 2, 2016 Orthopedic Implants (Including ... is Expected to Gain a Significant Market Share Owing to ... ... According to a new report ... Implants Sterile Packaging: Clamshell Product Type Segment Projected to Witness ...
Breaking Medicine Technology: