Navigation Links
Scientists Find Cancer Culprits in Cigarette Smoke
Date:2/28/2008

Hydrogen peroxide and other oxidants cause lung cells to become malignant

THURSDAY, Feb. 28 (HealthDay News) -- It's long been known that smoking causes lung cancer, but a new study is the first to show that the hydrogen peroxide in cigarette smoke is what actually causes healthy lung cells to turn cancerous.

Researchers from the University of California, Davis, said their findings may help lead to new treatments for lung cancer and may help the tobacco industry develop "safer" cigarettes by eliminating such substances in the smoke.

"With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets," senior author Tzipora Goldkorn said in a prepared statement.

In this laboratory study, the researchers exposed different sets of human lung cells to cigarette smoke or hydrogen peroxide and then incubated the cells for one to two days. The cells were then compared to unexposed airway cells. The cells exposed to cigarette smoke and those exposed to hydrogen peroxide showed the same molecular signatures of cancer development. The unexposed cells showed no such changes.

The findings are published in the March issue of The FASEB Journal, published by the Federation of American Societies for Experimental Biology.

Guns kill, bombs kill and cigarettes kill," Dr. Gerald Weissmann, editor-in-chief of The FASEB Journal, said in a prepared statement. "While biologists can't do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pinpoint new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in."

Cigarette smoking, which causes more than 400,000 deaths a year in the United States (about one in five of all deaths) is the leading preventable cause of premature death in the country, according to the U.S. Centers for Disease Control and Prevention. Smoking causes 90 percent of all lung cancer deaths in men and about 80 percent of lung cancer deaths in women.

Tobacco smoke contains more than 4,000 chemical compounds, including 43 that are know to cause cancer, according to a U.S. Surgeon General report released in 2000.

More information

The U.S. National Cancer Institute has more about smoking and cancer.



-- Robert Preidt



SOURCE: Federation of American Societies for Experimental Biology, news release, Feb. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
2. Scripps research scientists devise approach that stops HIV at earliest stage of infection
3. Scientists look at syringe assembly in plague bacteria
4. Scientists identify proteins that help bacteria put up a fight
5. CSHL scientists discover new details of a gene-regulatory network governing metabolism
6. Scientists make first map of emerging-disease hotpsots
7. Scientists shed light on long-distance signaling in developing neurons
8. Scientists explore consciousness
9. Scientists using laser light to detect potential diseases via breath samples, says new study
10. Scientists move towards stem cell therapy trials to mend shattered bones
11. U-M scientists develop tool to probe role of oxidative stress in aging, disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Cancer Culprits in Cigarette Smoke
(Date:2/17/2017)... ... February 17, 2017 , ... Like most hospitals across the ... in large part by the Hospital Readmission Reduction Program (HRRP), the return of a ... area for hospitals across the nation. While many providers are struggling to leverage limited ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Mason Pasquin Agency, ... and business owners in and around the Hampton Roads metropolitan region, is joining ... forms of domestic violence. , There are multiple categories of domestic violence – ...
(Date:2/16/2017)... ... February 17, 2017 , ... ... over 10 years of research, development and clinical trials, the founder of Chigurupati ... a patented compound of FDA approved ingredients that when infused into alcohol, protect ...
(Date:2/16/2017)... ... February 17, 2017 , ... Teaching nursing care of vulnerable children is ... ACE.P (pediatrics) is being created with the support of the Hearst Foundations. An initiative ... ACE.P will address what has been identified as a critical gap in preparing the ...
(Date:2/16/2017)... ... February 16, 2017 , ... As a reflection ... patient care, NWH has achieved Magnet® recognition for the second time, ... 2017. The American Nurses Credentialing Center’s Magnet Recognition Program® distinguishes organizations that meet ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Feb. 17, 2017   FormFast , the leader ... new partnership with Engage , one of the ... . FormFast will serve as the forms automation ... with MEDITECH .  FormFast is ... to complement and enhance the electronic health record. FormFast,s ...
(Date:2/17/2017)... 2017  Noble Capital Markets announced today that it ... EPIX ). The report was issued by ... PhD. ESSA Pharmaceuticals is a clinical stage ... (CRPC). Its lead compound EPI-506, is a small molecule ... the androgen receptor, thereby has potential to overcome some ...
(Date:2/16/2017)... -- DaVita Inc. (NYSE: DVA ) today announced ... Net income attributable to DaVita Inc. for ... million, or $0.80 per share and $880 million, or $4.29 ... to DaVita Inc. for the quarter and year ended December ... million, or $0.98 per share, and $789 million, or $3.85 ...
Breaking Medicine Technology: