Navigation Links
Scientists Find Cancer Culprits in Cigarette Smoke
Date:2/28/2008

Hydrogen peroxide and other oxidants cause lung cells to become malignant

THURSDAY, Feb. 28 (HealthDay News) -- It's long been known that smoking causes lung cancer, but a new study is the first to show that the hydrogen peroxide in cigarette smoke is what actually causes healthy lung cells to turn cancerous.

Researchers from the University of California, Davis, said their findings may help lead to new treatments for lung cancer and may help the tobacco industry develop "safer" cigarettes by eliminating such substances in the smoke.

"With the five-year survival rate for people with lung cancer at a dismally low 15.5 percent, we hope this study will provide better insight into the identification of new therapeutic targets," senior author Tzipora Goldkorn said in a prepared statement.

In this laboratory study, the researchers exposed different sets of human lung cells to cigarette smoke or hydrogen peroxide and then incubated the cells for one to two days. The cells were then compared to unexposed airway cells. The cells exposed to cigarette smoke and those exposed to hydrogen peroxide showed the same molecular signatures of cancer development. The unexposed cells showed no such changes.

The findings are published in the March issue of The FASEB Journal, published by the Federation of American Societies for Experimental Biology.

Guns kill, bombs kill and cigarettes kill," Dr. Gerald Weissmann, editor-in-chief of The FASEB Journal, said in a prepared statement. "While biologists can't do much about the first two, studies like this will help in the fight against tobacco-related death and disease. These experiments not only pinpoint new molecular targets for cancer treatment, but also identify culprits in cigarette smoke that eventually will do the smoker in."

Cigarette smoking, which causes more than 400,000 deaths a year in the United States (about one in five of all deaths) is the leading preventable cause of premature death in the country, according to the U.S. Centers for Disease Control and Prevention. Smoking causes 90 percent of all lung cancer deaths in men and about 80 percent of lung cancer deaths in women.

Tobacco smoke contains more than 4,000 chemical compounds, including 43 that are know to cause cancer, according to a U.S. Surgeon General report released in 2000.

More information

The U.S. National Cancer Institute has more about smoking and cancer.



-- Robert Preidt



SOURCE: Federation of American Societies for Experimental Biology, news release, Feb. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
2. Scripps research scientists devise approach that stops HIV at earliest stage of infection
3. Scientists look at syringe assembly in plague bacteria
4. Scientists identify proteins that help bacteria put up a fight
5. CSHL scientists discover new details of a gene-regulatory network governing metabolism
6. Scientists make first map of emerging-disease hotpsots
7. Scientists shed light on long-distance signaling in developing neurons
8. Scientists explore consciousness
9. Scientists using laser light to detect potential diseases via breath samples, says new study
10. Scientists move towards stem cell therapy trials to mend shattered bones
11. U-M scientists develop tool to probe role of oxidative stress in aging, disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Find Cancer Culprits in Cigarette Smoke
(Date:5/24/2017)... ... 24, 2017 , ... Medic CE , a Career Step company, is ... Shock” hosted by the Journal of Emergency Medical Services (JEMS). The free webinar, to ... presented by Captain Rommie Duckworth, LP, a career fire captain as well as founder ...
(Date:5/24/2017)... ... May 24, 2017 , ... Rob Lowe is a sought after actor, and ... “Informed” brings the public important topics from all aspects of life, and a new ... issues surrounding feet and ankles. , Podiatry is essential to people’s overall well-being, and ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... based sleep diagnostics sensors, announced today it had completed the first phase of ... mix of domestic and rest of world (ROW) authorized dealers specializing in polysomnography ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... the pharmaceutical and medical device sectors, today announced the winners of its 3rd ... Entrepreneurs) represent the most influential people in the healthcare industry today. , Out ...
(Date:5/23/2017)... ... ... The National Council on Strength and Fitness (NCSF), a ... Strength Coach credential has earned accreditation from the National Commission for Certifying Agencies ... qualified candidates for jobs in the Strength and Conditioning profession. The CSC distinction ...
Breaking Medicine News(10 mins):
(Date:5/23/2017)... PLEASANTON, Calif. , May 23, 2017 /PRNewswire/ ... world,s most innovative medical devices for pressure ulcer ... at the American Association of Critical Care Nurses, ... Houston May 22-25. The Leaf Patient ... designed specifically for the hospital environment.  The system ...
(Date:5/22/2017)... MAITLAND, Fla. , May 22, 2017 /PRNewswire/ ... industry as a whole continue to make the ... evidence becomes increasingly important for ensuring positive patient ... Key industry stakeholders are shifting focus away from ... results and effects of long-term specialty drug therapy ...
(Date:5/18/2017)... May 17, 2017  Bayer announced today that the ... be presented at the 53 rd Annual Meeting ... place June 2-6 in Chicago . ... span prostate, colorectal, liver and thyroid cancers, as well ... Phase II CHRONOS-1 trial of copanlisib in patients with ...
Breaking Medicine Technology: