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Scientists Explore Human Gene Pool With Help From Microsoft Research

disease and Alzheimer's disease.

* Department of Bioengineering, University of California, San Diego;

Division of Computer Science, University of California, Berkeley;

Trey Ideker and Richard Karp: "Pathway-Based Association: A New

Paradigm for Genome Wide Association Studies." Ideker and Karp

propose to help explain the associations captured by GWAS in terms

of known gene and protein interactions by developing computational

tools that help explain linkages between signaling, regulatory and

metabolic pathways to the genes that are associated with a disorder.

If successful, this research could have a positive impact on a broad

range of genomic studies.

* Columbia University, George Hripcsak: "Phenotypic Pipeline for

Genome-wide Association Studies." Large-scale studies involving many

subjects, or even smaller studies in which subjects are selected

from a larger population, will require innovative means to extract a

reliable, useful phenotype from electronic health records data.

Hripcsak proposes to develop advanced informatics methods to convert

raw health records data into usable research information.

* University of the Republic of Uruguay; Pasteur Institute at

Montevideo, Raul Ruggia and Hugo Naya: "Data Quality Management for

Model Improvement in GWAS." This project addresses the problems of

building a data-quality management environment for the biological

area, which would enable the user to define and evaluate

biological-oriented data-quality properties over specific data

sources. The biological-oriented properties would be defined in

terms of the basic ones, and the environment would use the existing

techniques that manage basic quality properties. The main expected


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