Navigation Links
Scientists Engineer Protein That Could Battle Strep
Date:3/6/2008

California team's discovery may lead to a vaccine that wards off infections

THURSDAY, March 6 (HealthDay News) -- A stabilized form of a protein found on streptococcus bacteria may provide protection against strep infections, a new study suggests.

A team led by University of California, San Diego (UCSD), researchers developed the first detailed description of the structure of the streptococcal M protein, which plays a critical role in the virulence of Group A Streptococcus (GAS), which causes a number of diseases, including strep throat, rheumatic fever and necrotizing fasciitis ("flesh-eating" disease).

The researchers conducted tests using M1 protein, the version of the M protein present on the most common disease-associated GAS strains. They also produced a variant of M1 that stimulates the immune system in mice, without causing any of the negative health effects of the natural M1 protein.

These investigations, described in the March 7 issue of Science, may help scientists develop M1 protein-based vaccines against GAS, the researchers said.

"Using X-ray crystallography, we determined that M1 protein has an irregular, unstable structure. We created a modified version of M1 with a more stable structure, and found that it is just as effective at eliciting an immune reaction, but safer than the original version of M1, which has serious drawbacks to its use as a vaccine," Partho Ghosh, a professor of chemistry and biochemistry in UCSD's Division of Physical Sciences, said in a prepared statement.

"Certain antibodies that are produced by the immune system against M1 protein have been shown to cross-react with normal human tissues, including heart muscle, potentially triggering the serious autoimmune disease known as rheumatic fever," said Victor Nizet, a professor of pediatrics and pharmacy at the UCSD School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences.

"M1 protein can also act as a toxin, producing clotting abnormalities and lung injury when injected into mice. Therefore, our results with modified M1 provide very novel insight about the role of M proteins in invasive GAS disease and rheumatic heart disease," Nizet said in a prepared statement.

Each year, strep infections afflict more than 600 million people worldwide and kill 400,000, according to background information in a news release about the research.

More information

The U.S. Centers for Disease Control and Prevention has more about Group A Strep.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, March 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of I scientists aim to overcome allergic reactions to soy
2. Congressional R&D Caucus co-chairs join scientists, engineers and graduate students
3. Scientists find mercury threatens next generation of loons
4. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
5. Scientists discover who is likely to get dry eye syndrome after LASIK surgery
6. Scientists uncover further steps leading to celiac disease
7. Scientists Find Cancer Culprits in Cigarette Smoke
8. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
9. Scripps research scientists devise approach that stops HIV at earliest stage of infection
10. Scientists look at syringe assembly in plague bacteria
11. Scientists identify proteins that help bacteria put up a fight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Engineer Protein That Could Battle Strep
(Date:12/7/2016)... PITTSBURGH, PA (PRWEB) , ... December 07, 2016 , ... ... and regular changing of the securement tape is painful for her. "This is why ... cannula’s to patients’ heads," she said. , They then created a prototype of the ...
(Date:12/7/2016)... ... 2016 , ... A. Kevin Spann Insurance, a New York-based firm offering insurance ... launching a charity drive to raise funds that will benefit the Marine Corps League. ... and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann team ...
(Date:12/7/2016)... ... 07, 2016 , ... Sharon Kleyne, host of the nationally syndicated radio program, ... Voice of America, declared on her radio program in November 2016 the need to ... these bullies attack leaders in corporate America, they are trying to take advantage of ...
(Date:12/7/2016)... ... December 07, 2016 , ... Facial plastic surgeon, Dr. John D. Rachel ... a portion of proceeds to two local organizations: North Chicago Animal Control and Friends ... is a team of authorized and trained volunteers who support rescued animals held ...
(Date:12/7/2016)... Dallas, TX (PRWEB) , ... December 07, 2016 ... ... service based in Dallas, Texas, is condemning "scam operations" carried out by unethical ... to bring these scam operations to a halt. According to Texas Premier Locksmith, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016  Haemonetics Corporation (NYSE: HAE ) ... System), an innovative software suite designed to help customers drive ... launch of NextGen DMS 4 improves core features and introduces ... per liter of plasma collected, enhancing quality and regulatory compliance ... ...
(Date:12/8/2016)... December 8, 2016 Stock-Callers.com revisits ... research, distribution, and marketing of pharmaceutical drug products. Companies ... protection and expiration. Additionally, these firms typically have dividend ... a whole. Up for review this morning are: Novo ... Inc. (NASDAQ: SGYP ), Pernix Therapeutics Holdings ...
(Date:12/8/2016)... Eli Lilly and Company (NYSE: ... abemaciclib, a cyclin-dependent kinase (CDK) 4 and CDK 6 ... Ki67, a biomarker of cell proliferation, after two weeks ... presented during the official press program at the 2016 ... alone or in combination with the non-steroidal aromatase-inhibitor anastrozole, ...
Breaking Medicine Technology: