Navigation Links
Scientists Discover Trigger for Autoimmune Diseases
Date:12/22/2008

Self-attacking, dormant cells switch 'on' in those with lupus, rheumatoid arthritis

MONDAY, Dec. 22 (HealthDay News) -- Healthy adults have potential autoimmune disease-causing cells, but these cells stay in an "off" state, a U.S. study shows.

Immune cells that attack the body cause autoimmune diseases such as lupus and rheumatoid arthritis (RA). Whether the switched-off cells in healthy adults are true precursors of the self-attacking immune cells and, if so, what prevents them from causing disease in certain people, isn't known, the researchers said.

J. Andrew Duty, of the Oklahoma Medical Research Foundation, and colleagues found that anergic (dormant) autoimmune disease-causing cells account for 2.5 percent of immune B-cells circulating in the blood of healthy adults.

These anergic cells don't appear to cause problems in healthy adults, but did produce self-reactive antibodies when exposed to a strong stimulus in lab experiments. This means these anergic cells may contain the precursors for the self-attacking B-cells in patients with autoimmune disease, the researchers said.

In previously healthy people, anergy may somehow break down and allow self-attacking B-cells to cause autoimmune disease.

The study was published in the Dec. 22 online issue of The Journal of Experimental Medicine.

More information

The U.S. National Women's Health Information Center has more about autoimmune diseases.



-- Robert Preidt



SOURCE: Rockefeller University Press, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Scientists Spot Key to Cystic Fibrosis Infections
2. Scientists, Physicians, Health, and Environmental Justice Advocates to New Obama EPA Director: We Look Forward to Toxic Chemical Regulatory Reform
3. Seven life scientists get research boost to set up in Europe
4. UC San Diego scientists developing brain imaging methods for studying natural human behavior
5. Scientists ID Enzyme Causing Brain Cell Death
6. NASA scientists provide update on existing remote sensing technology programs and new projects
7. Scientists ID Protein Aiding Breast Cancer Spread
8. UCLA scientists prove endothelial cells give rise to blood stem cells
9. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
10. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
11. Carnegie Mellon scientists offer explanation for face blindness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Discover Trigger for Autoimmune Diseases
(Date:4/17/2014)... April 17, 2014 Meaningful long-term survival is ... of the abdomen when treated with cytoreductive surgery ... a first-of-its-size analysis by physicians at Wake Forest ... the largest reported, single-center experience with cytoreductive surgery ... M.D., and analysis of 20 years, worth of ...
(Date:4/17/2014)... shocking rates of suicide are highest in areas with ... smallholdings less than one hectare and trying ... that are highly susceptible to global price fluctuations. , ... that point to a crisis in key areas of ... economy during the 90s. Researchers say that policy intervention ...
(Date:4/17/2014)... Queen,s University Belfast,s Vice-Chancellor, Professor Patrick Johnston, whose work ... elected as a Fellow of the European Academy of ... is an independent advisory body of highly distinguished oncologists ... and suffering caused by cancer in Europe. , Professor ... Northern Ireland move from the bottom of the UK ...
(Date:4/16/2014)... Consider the marvel of the embryo. It begins as a ... they multiply to become the cells of our lungs, muscles, ... , Now, in a feat of reverse tissue engineering, Stanford ... that allows embryonic cells to proliferate and transform into all ...
(Date:4/16/2014)... (April 16, 2014) A team that includes scientists from ... Science Center at San Antonio, Johns Hopkins University and St. ... a common fungus to infect the body. , The fungal ... and oral thrush, and is the most common fungal pathogen ...
Breaking Medicine News(10 mins):Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 3Health News:Stanford scientists develop 'playbook' for reverse engineering tissue 2Health News:Stanford scientists develop 'playbook' for reverse engineering tissue 3
... HOPKINTON, Mass., Feb. 23 Caliper Life Sciences, Inc. ... call discussing the company,s fourth quarter 2008 financial results ... Kevin Hrusovsky, President and Chief Executive Officer and Peter ... will discuss operational and financial results and the company,s ...
... - First Aid Charity Implements ... Volunteers Quickly and Effectively , ... selected the autonomous,web-based SMS solution from Text Messaging ... its substantial,volunteer base throughout the Sussex region via ...
... with degenerative disc disease , , MONDAY, Feb. 23 (HealthDay ... outcomes for people who have surgery for degenerative disc ... an attempt to find ways to stop or reverse ... from disc tissue removed during surgery and cultivating the ...
... commitment to customer service, ApothecaryRx provides tips to ... VALLEY, Minn., Feb. 23 The ... choices to make ends meet, including foregoing the ... and well being. Worried that some patients may ...
... Operational Efficiencies MIAMI, Feb. 23 Miami ... with a medical staff of more than 650 physicians ... a leader in providing children,s healthcare and as one ... hospital,s staff found itself facing a problem familiar to ...
... MVP Lisa Leslie Urge Teens to Stay in the ... The National Basketball Association (NBA) and the Women,s National ... Adolescent Medicine (SAM) and sanofi pasteur (the vaccines division ... Vaccines for Teens , a national multimedia campaign ...
Cached Medicine News:Health News:Caliper Life Sciences' Fourth Quarter 2008 Financial Results Conference Call Notice 2Health News:St John Ambulance Selects Web-Based SMS Solution From Text Messaging Centre (TMC) for Rapid Response Communication via Two-Way SMS Messaging 2Health News:St John Ambulance Selects Web-Based SMS Solution From Text Messaging Centre (TMC) for Rapid Response Communication via Two-Way SMS Messaging 3Health News:Anti-Cholesterol Drug May Ease Back Pain 2Health News:Cost-Saving Prescription Drug Tips: Just What the Doctor Ordered 2Health News:Cost-Saving Prescription Drug Tips: Just What the Doctor Ordered 3Health News:Miami Children's Hospital Increases Efficiency With MediTract's Contract Management Solution 2Health News:Miami Children's Hospital Increases Efficiency With MediTract's Contract Management Solution 3Health News:Miami Children's Hospital Increases Efficiency With MediTract's Contract Management Solution 4Health News:NBA and WNBA Help Teens Take Their Best Shot at Health With New Vaccines for Teens Educational Campaign 2Health News:NBA and WNBA Help Teens Take Their Best Shot at Health With New Vaccines for Teens Educational Campaign 3Health News:NBA and WNBA Help Teens Take Their Best Shot at Health With New Vaccines for Teens Educational Campaign 4Health News:NBA and WNBA Help Teens Take Their Best Shot at Health With New Vaccines for Teens Educational Campaign 5
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ( ... "Dental Consumables Market - Global Industry Analysis, Size, Share, ... to their offering. (Logo: ... which are used on patients in order to treat ...
(Date:1/15/2014)...  Celsion Corporation (the "Company") (NASDAQ: CLSN ) ... investors to purchase an aggregate of approximately $15 million ... direct offering, led by a dedicated health care fund. ... with these investors pursuant to which the Company agreed ...
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its ... highly sophisticated agro-breeding solutions for plant breeders and researchers, ... board of directors appointed chemistry and pharmaceutical industry expert ... of the board. From 1975 to 2012, ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... 20 What happens when leading,biochemists get together ... therapies are born. Recently, this same scenario,began when ... behind,the leading treatments for type 2 diabetes, a ... side effects caused by the current therapy like,high ...
... IRVINE, Calif., March 20 IDM Pharma, Inc.,(the ... it has initiated,enrollment in a clinical protocol finalized ... provides mifamurtide (L-MTP-PE) to eligible,high-risk osteosarcoma patients through ... is in response to the increasing number of,requests ...
Cached Medicine Technology:IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 2IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 3IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 4IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 5
... The SR™ Hand Implant System utilizes ... and knee joint replacements. The SR™ ... available in other prostheses including minimal bone ... eroded cartilaginous articular surfaces, retention and/or repositioning ...
Anatomic implant shape and easy-to use instrumentation promote implant alignment, stability, and restored joint kinematics....
The NeurOptics Pupillometer is a portable instrument used to measure pupils to screen candidates for refractive procedures and other ophthalmic applications....
... closely match the natural anatomy of ... Titanium construction incorporates an 8-degree cranial ... design prevents screws from backing out. ... for X-ray control of the procedure. ...
Medicine Products: