Navigation Links
Scientists Discover New Drug Targets for Crohn's Disease
Date:2/26/2009

Gene-searching method uncovered more players in painful gastrointestinal condition

THURSDAY, Feb. 26 (HealthDay News) -- An international team of researchers has pinpointed new genetic targets for drugs to treat Crohn's disease, a chronic and painful condition caused by inflammation of the gastrointestinal tract.

The Children's Hospital of Philadelphia-led group used a new gene-searching method, combining a statistical tool that identifies genes interacting on the same biological pathways with highly automated gene-hunting techniques that scan the whole genome.

An initial analysis was performed on DNA from 1,758 Crohn's patients and 1,480 people without the disease. All of them were of European ancestry. The analysis was repeated in three more groups, of both European and African ancestry.

"Among hundreds of known biological pathways, the one that surfaced from the analysis as being most significant included genes already known to be relevant to the biology of Crohn's disease," study leader Dr. Hakon Hakonarson, director of the Center for Applied Genomics at Children's Hospital, said in a news release from the hospital.

The interleukin 12 (IL12) pathway governs cell receptors involved in the developed of Crohn's disease. Previous research has found that monoclonal antibodies that block the IL12 receptor show some clinical success in treating Crohn's disease.

The study was published online and in the March 13 print issue of The American Journal of Human Genetics.

"As we better understand the gene pathways operating in Crohn's disease, we are uncovering more potential targets for effective drug treatments," study co-author Dr. Robert Baldassano, a pediatric gastroenterologist and director of the Center for Pediatric Inflammatory Bowel Disease at Children's Hospital, said in the same news release.

Developing targeted therapies based on gene pathways might enable doctors t
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Discover New Drug Targets for Crohn's Disease
(Date:7/25/2014)... Staffordshire, UK (PRWEB) July 26, 2014 ... a variety of dental services including general dentistry, clear ... practice opening in September this year in Derby. The ... is at the HollyBrook Medical Centre in Littleover, Derby. ... the new practice. , The new dental practice, which ...
(Date:7/25/2014)... According to a new market research report "Machine ... ultrasound emission, lubricating oil analysis, corrosion monitoring, motor ... Global Forecast to 2014 - 2020", published by ... to reach $2.50 at a CAGR of 7.16% ... data Tables and 57 Figures spread through 353 ...
(Date:7/25/2014)... New York, NY (PRWEB) July 25, 2014 ... cut ticket prices across the board for the Guinness ... Liverpool FC and Olympiacos FC at Soldier Field ... is also offering their customer appreciation promo/coupon/offer code SOCCER-2014 ... be an amazing year for diehard soccer fans in ...
(Date:7/25/2014)... July 25, 2014 As reported by Wood ... Deaths Increase (7/20), Michigan has seen a nearly 500-person increase ... While the count was 271 between 1999 and 2002, the ... Agents believe that, like other states, drug users in Michigan ... via prescription pills. He compared the price of both substances, ...
(Date:7/25/2014)... News) -- The human brain can preserve oxygen to ... study finds. Although dehydration significantly reduces blood ... that the brain compensates by increasing the amount of ... has helped us understand a lot more about how ... conditions," study first author Steven Trangmar, a researcher at ...
Breaking Medicine News(10 mins):Health News:Derby Cosmetic Dentist Dental Perfection to Open New Practice in Littleover, Derby this September 2Health News:Machine Health Monitoring Market by Product, Component & Application Worth $2.50 Billion by 2020 - New Report by MarketsandMarkets 2Health News:Machine Health Monitoring Market by Product, Component & Application Worth $2.50 Billion by 2020 - New Report by MarketsandMarkets 3Health News:Machine Health Monitoring Market by Product, Component & Application Worth $2.50 Billion by 2020 - New Report by MarketsandMarkets 4Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Rise in Heroin Use, Overdose Deaths in Michigan 2Health News:Human Brain Has Coping Mechanism for Dehydration 2
... Taking a prenatal vitamin ... launches its first product, S7 Prenatal™ Drink Mix, the first of its kind. The ... be good for you. To celebrate the launch, the company is offering a free two ... ...
... ... market and is now available through leading cold laser retailer Cold Laser-Therapy-US. The new programmable ... more readily available to the medical field. , ... Cape Girardeau, MO (PRWEB) July 27, 2009 - Cold laser equipment ...
... , SANTA MONICA, Calif., July ... and FIZ Karlsruhe, a European-based provider of information delivery ... article ePrint procurement service within the FIZ AutoDoc full-text ... offering enables FIZ AutoDoc customers, including dozens of major ...
... Government health officials from 13 African countries today launched ... laboratories, starting a process that the World Health Organization ... historic step to strengthen health systems and lead to ... Africa,s laboratories are now accredited, in part because the ...
... years, oncologists have debated whether patients with a certain ... Now a major study published in the journal ... standard chemotherapy and radiation can be an option for ... lung cancer, but does not dramatically improve overall survival ...
... ... Giant MARIJUANA BUD to Protest San Francisco Indoor Gardening Expo Censorship that,s Hurting Medical Marijuana ... ... the 6th annual San Francisco Indoor Gardening Expo, but this year,s Expo will be greeted ...
Cached Medicine News:Health News:Moms, Registered Dietitian, Develop the First All-In-One Prenatal Vitamin in a Great Tasting Drink Mix 2Health News:Cold Laser Technology Made Even More Accessible with Powerful New Product Available from Laser-Therapy.US 2Health News:Reprints Desk Makes Pharmaceutical ePrint Procurement Service Available Through FIZ AutoDoc Document Delivery System 2Health News:Reprints Desk Makes Pharmaceutical ePrint Procurement Service Available Through FIZ AutoDoc Document Delivery System 3Health News:Leading health organizations launch new accreditation process for laboratories across Africa 2Health News:Leading health organizations launch new accreditation process for laboratories across Africa 3Health News:Leading health organizations launch new accreditation process for laboratories across Africa 4Health News:Surgery remans an option for advanced lung cancer 2Health News:Giant Bud Banner Half the Size of Football Field Flies Sunday Protesting Hydroponics Industry Cartel Monopoly that's Harming California's Medical Marijuana Patients 2Health News:Giant Bud Banner Half the Size of Football Field Flies Sunday Protesting Hydroponics Industry Cartel Monopoly that's Harming California's Medical Marijuana Patients 3
(Date:7/25/2014)... 2014  Solanbridge Group Inc (OTC: SLNX) is pleased ... in Buzznbrewz.com and the Letter of Intent issued on ... executed Purchase Agreement. Charles R. Shirley ... to have Mr. David Pecoraro and Buzznbrewz.com ... the private sector and developed a tremendous network of ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Diagnostic Devices Market 2014-2018" report to their offering. ... About Ophthalmic Diagnostic Device An ophthalmic ... a defect or deficiency in the human visual pathway. ... such as presbyopia, cataracts, glaucoma, retinal disorders, conjunctivitis, and ...
(Date:7/25/2014)... , July 25, 2014  Semler Scientific, Inc. ... medical risk assessment company that develops patented products ... evaluating chronic diseases, today reported financial results for ... 30, 2014. "The second quarter ... said Doug Murphy-Chutorian , M.D., chief executive ...
Breaking Medicine Technology:Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2Semler Reports Second Quarter 2014 Financial Results 2Semler Reports Second Quarter 2014 Financial Results 3
... NEW YORK, May 18, 2011 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p0498665/Machine-to-Machine-M2M-Communications-in-Healthcare-2010-20.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Healthcare ... healthcare applications will be huge, EUR69 billion ...
... Bayer HealthCare Pharmaceuticals, Inc. announced today that data ... presented in a scientific forum at the 2011 Annual ... June 3-7, in Chicago, IL.   "Bayer ... in late-stage development, and our researchers are working tirelessly ...
Cached Medicine Technology:Reportlinker Adds Machine-to-Machine (M2M) Communications in Healthcare 2010-20 2Reportlinker Adds Machine-to-Machine (M2M) Communications in Healthcare 2010-20 3Bayer to Present Data on Investigational Oncology Compounds at 2011 Annual Meeting of the American Society of Clinical Oncology (ASCO) 2
... Rusch Safety Clear Plus™ Cuffed Endotracheal Tube ... stylet inside. Sterile, Single use. A quality Rusch ... ready to use saving you time and storage ... to facilitate smooth withdrawal. It is designed with ...
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. Murphy eye. High volume/low pressure cuff. Connector is permanently fixed into the tube. X-ray opaque. Graduated. Single use. Steri...
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. High volume/low pressure cuff. Permanent connector. X-ray opaque. Single use. Sterile...
... with Murphy eye. Laser resistant foam surrounds the ... (One inside other) 40cm (16") long, Single Use. ... access and optimum visibility within the operating site, ... a special laser-guard of approx. 17cm in length ...
Medicine Products: