Navigation Links
Scientists Discover New Drug Targets for Crohn's Disease
Date:2/26/2009

Gene-searching method uncovered more players in painful gastrointestinal condition

THURSDAY, Feb. 26 (HealthDay News) -- An international team of researchers has pinpointed new genetic targets for drugs to treat Crohn's disease, a chronic and painful condition caused by inflammation of the gastrointestinal tract.

The Children's Hospital of Philadelphia-led group used a new gene-searching method, combining a statistical tool that identifies genes interacting on the same biological pathways with highly automated gene-hunting techniques that scan the whole genome.

An initial analysis was performed on DNA from 1,758 Crohn's patients and 1,480 people without the disease. All of them were of European ancestry. The analysis was repeated in three more groups, of both European and African ancestry.

"Among hundreds of known biological pathways, the one that surfaced from the analysis as being most significant included genes already known to be relevant to the biology of Crohn's disease," study leader Dr. Hakon Hakonarson, director of the Center for Applied Genomics at Children's Hospital, said in a news release from the hospital.

The interleukin 12 (IL12) pathway governs cell receptors involved in the developed of Crohn's disease. Previous research has found that monoclonal antibodies that block the IL12 receptor show some clinical success in treating Crohn's disease.

The study was published online and in the March 13 print issue of The American Journal of Human Genetics.

"As we better understand the gene pathways operating in Crohn's disease, we are uncovering more potential targets for effective drug treatments," study co-author Dr. Robert Baldassano, a pediatric gastroenterologist and director of the Center for Pediatric Inflammatory Bowel Disease at Children's Hospital, said in the same news release.

Developing targeted therapies based on gene pathways might enable doctors to tailor treatments to a patient's genetic profile, he added.

More information

The Crohn's and Colitis Foundation of American has more about Crohn's disease.



-- Robert Preidt



SOURCE: Children's Hospital of Philadelphia, news release, Feb. 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Discover New Drug Targets for Crohn's Disease
(Date:12/2/2016)... ... , ... For over twenty-four years, Doctors on Liens has published a directory of ... quality medical care. When the company started in 1997, the directory was a single ... and the now ten-page directory features a vast array of medical specialists stretching ...
(Date:12/2/2016)... Portland, Maine (PRWEB) , ... December 02, 2016 , ... ... support group for caregivers of those affected by autism spectrum disorder (ASD) and other ... and Easter Seals Maine, will give parents and other caregivers the opportunity to share ...
(Date:12/2/2016)... New York, NY (PRWEB) , ... December 02, ... ... today, featuring an inspirational interview of two ostomy patients, standing as living proof ... million people suffer from digestive diseases and issues that spike around the holidays. ...
(Date:12/2/2016)... Wilmington, Delaware (PRWEB) , ... December 02, 2016 ... ... has released a new version of its SaaS LIMS, CloudLIMS Lite. CloudLIMS Lite ... from sample entry through labeling, storing, shipping and disposal. The new version is ...
(Date:12/2/2016)... PA (PRWEB) , ... December 02, 2016 , ... Rijuven ... stress and overall health, day and night. No other wearable health technology on the ... We wanted to give poeple more meaningful insights about their health than the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... OLD LYME, Conn. , Dec. 1, 2016 /PRNewswire/ ... consulting, has announced the honor of being selected as ... that include: Simpson Healthcare Executives Website at the PLATINUM ... Directed Conversations Training Module at the GOLD Level, and ... At Simpson Healthcare Executives, we are ...
(Date:12/2/2016)... , Dec. 2, 2016 Allergan plc (NYSE: ... additional information on its previously announced Accelerated Share Repurchase (ASR) ... ... As previously announced, the Company entered into ... which the Company will repurchase $10 billion of its ordinary ...
(Date:11/30/2016)... -- Research and Markets has announced the addition of ... report to their offering. ... Detachable coil embolization is a minimally ... detachable coil embolization treatment of cerebral aneurysms is less invasive and requires ... in the wall of an artery in the brain. This area bulges ...
Breaking Medicine Technology: