Navigation Links
Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
Date:2/15/2010

lecular program for organ development that also is beneficial to tissue repair," said Dr. Lang. "This study also indicates the pathway may be important to tissue regeneration and repair in other organs."

Wnt7b is part of the Wnt family of proteins, which are known to help regulate cells as they proliferate, grow and become specific cell types for the body. Wnt proteins have also been linked to the regulation of stem cells in bone marrow and skin, which suggested to researchers of the current study that Wnt might have a role in tissue regeneration.

The researchers conducted a number of experiments of kidney injury in mice to identify the repair pathway, finding that:

  • Silencing macrophage white blood cells through a process called ablation reduced the response level of Wnt proteins to injured kidney cells.
  • Deleting the Wnt7b protein from macrophages diminished normal tissue repair functions in injured kidneys.
  • Injecting into the injured kidneys a protein calked Dkk2, which is known to help regulate the Wnt pathway during embryonic development, enhanced the macrophage-Wnt7b repair process. This also restored epithelial surface cells that line internal kidney surfaces and suggested a therapeutic potential for the pathway.

Drs. Lang and Duffield said the repair pathway may benefit other injured organs because macrophages act somewhat like a universal emergency responder in the body, rushing to injured tissues wherever damage occurs. Another factor is the central role the Wnt pathway plays in cell regulation and function throughout the body.

Other collaborating institutions in the study include: the Department of Structural Biology, St, Jude Children's Hospital, Memphis, Tenn.; the departments of Internal Medicine and Molecular Biology, University of Texas'/>"/>

SOURCE Cincinnati Children's Hospital Medical Center
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Prevention Is Key Research Goal for Premature Babies, Scientists Say
2. Scientists Discover How HIV Is Transmitted Between Men
3. Scientists Pinpoint Area of Brain That Fears Losing Money
4. Scientists Spot Genes Tied to Aging
5. UM School of Medicine scientists find new malaria vaccine is safe and promotes immune response in children
6. Scientists ID a protein that splices and dices genes
7. Breakthrough by Danish scientists in preventing maternal malaria
8. NIH scientists identify maternal and fetal genes that increase preterm birth risk
9. UM School of Medicine scientists find new malaria vaccine is safe and protective in children
10. Gladstone scientists identify target that may reduce complications of obesity
11. Scientists map out regulatory regions of genome, hot spots for diabetes genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... 01, 2015 ERISAPros is ... Carolyn Roddy to the professional staff of its Compliance ... from The Ohio State University-Mortiz College of Law. Prior ... experience working with several Fortune 500 companies as well ... of corporate benefits. Her experiences range from benefit plan ...
(Date:2/28/2015)... Malaysia (PRWEB) February 28, 2015 The ... all across Malaysia into one platform and gears towards ... , A series of group talks in smaller ... like Nation Building, Education, Personal Development, Leadership, Entrepreneurship, Healthcare, ... and raise awareness of Malaysian youths. , ...
(Date:2/28/2015)... Gerald “Solutionman” Haman surveyed over 10,000 people ... innovative thinking. “The #1 block was lack of ... reports Haman, who created the Thinkubator Innovation Studio in ... that they did not have enough time for innovative ... stimulate innovation. , Solutionman’s monthly “Accelerating Innovation Training” workshops ...
(Date:2/28/2015)... 28, 2015 March—also known as ... to remind ourselves and others that suspected head ... NeuroSurgical Specialists (ANS). , Concussions are a form ... 75% of TBIs. There are 1.6-3.8 million sports-related ... benign, but it is a brain injury. Many ...
(Date:2/28/2015)... A study out of the University ... procedure for the treatment of a hereditary ocular condition ... Authored by Dr. Robert MacLaren, professor of ophthalmology at ... Medical Journal on January 16, 2014 , the study ... disorder that mostly affects men and leads to the ...
Breaking Medicine News(10 mins):Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 3Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 4Health News:New Survey Reveals “Lack of Time” Is the Number #1 Barrier to Innovative Thinking 2Health News:New Survey Reveals “Lack of Time” Is the Number #1 Barrier to Innovative Thinking 3Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 2Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 3Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2
... is EBCC? , The most exciting breast cancer conference ... all the major players in breast cancer. The conference ... in a partnership of equals to talk not just ... and practical issues associated with caring for patients with ...
... and the,Aronson Foundation, a charitable organization, recently presented a ... The gift,raised from and by Aronson & Company staffers, ... the young patients., Commented Lisa J. Cines, Managing ... further support the hospital in their efforts to help,the ...
... 9 Percent to $12.4 Billion, ARLINGTON HEIGHTS, ... and a looming home lending crisis, average,Americans continue ... the,latest procedural statistics report from the American Society ... surgery procedures were,performed in 2007 - a 7 ...
... Scot Rourke, President and CEO of,OneCommunity, has been ... 2008 by the Intelligent Community Forum (ICF), (http://www.intelligentcommunity.org ... to,studying economic growth in the Broadband Economy., ... in Cleveland, Ohio today.,Rourke will make the Intelligent ...
... Survey Shows Increasing Use of Tiered Copayments, Generics, ... WASHINGTON, March 25 A new survey of,employers ... tools,has helped to slow the cost of prescription ... manager (PBM) tools in increasing savings,and access for ...
... This release is available in German . , , ... these common figures of speech can be taken literally, ... of us would like. For it turns out that intense ... and increase the risk of thrombosis or heart attack. , ...
Cached Medicine News:Health News:An invitation to Europe's largest forum on breast cancer 2Health News:The Aronson Foundation Makes Charitable Donation to Children's Hospital 2Health News:Plastic Surgery Procedures Maintain Steady Growth in 2007 2Health News:OneCommunity's Scot Rourke Named Intelligent Community Visionary of the Year for 2008 2Health News:Employers: Proven PBM Tools Slowing Cost of Prescription Drug Benefits 2Health News:Fear that freezes the blood in your veins 2Health News:Fear that freezes the blood in your veins 3
(Date:2/27/2015)... -- Uroplasty, Inc. (NASDAQ: UPI ), a medical device ... to treat voiding dysfunctions, today announced that it will ... March 10, 2015. Rob Kill , President and ... will present at 4:00 p.m. Pacific Time and meet ... the Ritz Carlton in Laguna Niguel, CA. ...
(Date:2/27/2015)... 2015  Two mass spectrometry technologies MALDI ... their effectiveness is established, according to biotechnology ... says that while mass spectrometry (mass spec ... in proteomic biomarker discovery and validation, mass ... techniques has struggled to elucidate molecular distribution ...
(Date:2/26/2015)... 2015  Tandem Diabetes Care®, Inc. (NASDAQ: ... the t:slim® and t:flex™ Insulin Pumps, today announced the ... of its common stock at a price to the ... Tandem from this offering are expected to be $56.3 ... estimated offering expenses payable by Tandem. All of the ...
Breaking Medicine Technology:Uroplasty to Participate in the 27th Annual ROTH Conference 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 2Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 3
... CHAPEL HILL, N.C., Oct. 25, 2011 While some ... in today,s crowded, competitive marketplace.   ... new products, companies must think strategically about clinical and ... serve as the gatekeepers to a product,s acceptance in ...
... 2011 The Medical Design Excellence Awards ... from companies and individuals worldwide that are involved in the ... medical packaging products. (Logo:   http://photos.prnewswire.com/prnh/20101214/LA16070LOGO ) ... and sponsored by MD+DI ...
Cached Medicine Technology:Latest Pharmaceutical Launch Strategies Demonstrate Growing Importance of Thought Leader Engagement at Market Entry 2UBM Canon's 2012 Medical Design Excellence Awards Calls for Entries 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: