Navigation Links
Scientists Discover How Stomach Tumors Form
Date:4/23/2008

Blocking IL-11 protein prevents inflammation, hints of new treatments for disease

WEDNESDAY, April 23 (HealthDay News) -- Scientists say they may have discovered how tumors develop in the stomach, a finding that could lead to new treatments for gastric cancer.

In a study done on mice, scientists at the Melbourne Branch of the International Ludwig Institute for Cancer Research (LICR) found that blocking the signaling pathway of the IL-11 protein -- either through genetic manipulation or with medications -- would prevent certain inflammation, hyperplasia (an abnormal increase in the number of cells), and tumor formation in pre-clinical models of stomach cancer.

Stomach cancer, the second most common cause of cancer-related deaths worldwide, has been shown previously to be correlated with chronic inflammation.

The findings were published online April 22 in The Journal of Clinical Investigation.

The study shows that IL-11 promotes chronic inflammation and the formation of tumors in the stomach by increasing activation of the Stat3 protein, a known player in inflammation-associated carcinogenesis. Excessive Stat3 activity is often found in gastric and other types of cancer. The underlying cause of the Stat3 issue had previously been unknown.

"The clear link between inhibition of IL-11/Stat3 activity and suppression of gastric tumorigenesis that we identified supports the further development of pharmacologic agents that target these molecules for the treatment of gastric and potentially other cancers," study author Matthias Ernst, from the LICR Melbourne Branch, said in a prepared statement. "We believe that we have a very relevant model in our hand for the preclinical assessment of such compounds as well as for the identification of potential markers that may ultimately help in the early detection of disease."

More information

The American Cancer Society has more about stomach cancer.



-- Kevin McKeever



SOURCE: Ludwig Institute for Cancer Research, news release, April 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. U.S. Scientists Receive Japan Prize on April 23, 2008
2. Scientists discover a mechanism that can send cells on the road to cancer
3. Scientists identify novel way to prevent cardiac fibrosis
4. Scientists Explore Human Gene Pool With Help From Microsoft Research
5. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
6. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
7. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
8. Stem cells and cancer: Scientists investigate a fine balancing act
9. Scientists Block Prostate Cancer Cells Spread
10. Scientists solve mystery of polyketide drug formation
11. Scientists Uncover How HIV Hides Inside Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: