Navigation Links
Scientists Discover How Chemo Can Make Women Infertile
Date:9/28/2009

ects in offspring. In particular, cisplatin, which was studied in this trial, causes specific types of chromosomal damage.

Cisplatin is primarily usually used to treat ovarian cancer, Attia noted.

In this study, Gonfloni and her colleagues showed that cisplatin promotes the death of oocytes, or female germ cells, by way of the c-Abl enzyme, a protein that, when mutated, can also cause chronic myeloid leukemia (CML).

But targeting the enzyme with imatinib (Gleevec), a drug used to treat CML, protected the oocytes from the ill effects of cisplatin.

"These results raise the possibility of protecting ovarian function during cancer treatments, thereby preserving the fertility in female cancer survivors," Gonfloni added.

But how to use one drug without compromising the other?

"First, we have to show that imatinib can be used to prevent chemotherapy-induced ovarian toxicity without interfering with anti-cancer treatments," Gonfloni said. "In other words, we have to prove that tumor-bearing laboratory animals can be cured with a combined cisplatin and imatinib treatment, while at the same time preserving fertility," she explained.

"Then, for any clinical implications, it will be very important to prove the same protective effect of a specific dosage of imatinib on human oocytes cultured and challenged with chemotherapeutic drugs in vitro," she added.

And preserving fertility is not always the right thing, Astsaturov said.

"Chemotherapy induces menopause in some hormone-dependent cancers. It has a beneficial effect because it's withdrawing the stimulants for the cancer cells. Menopause is contributing to the cure," he said. "It's still debated whether we should preserve menstrual function at all costs."

More information

Visit Cancer Research UK for more on chemotherapy and fert
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Scientists May Know How Lung Cancer Spreads
2. UCSF scientists illuminate how microRNAs drive tumor progression
3. Glaxo Official Memo Urged Scientists to Withhold Information About Paxils Risks, Trial Hears; Pharmaceutical Industry Today Offers Complete News Coverage
4. University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk
5. Scientists Spot Key to Breast Cancer Spread
6. Scientists Find Clue to Dangerous Side Effect of MS Drug
7. Scientists Spot Clue to Cancers Aggressiveness
8. Scientists Turn Off Obesity Switch in Mice
9. NIBIB scientists increase imaging efficiency in cell structure studies
10. Scientists Make Sweet Monkey Music
11. Scientists from University of Hawaii at Manoa find genetic marker
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Discover How Chemo Can Make Women Infertile
(Date:1/23/2015)... 2015 Hastings and Hastings, a law firm ... record number of legal representation client review requests for slip ... a steady rise in the number of slip and fall ... throughout the Valley. With that said, a large number of ... an experienced law firm. Hastings and Hastings is a personal ...
(Date:1/22/2015)... 23, 2015 LunaDress, with its top dressmaking ... industry. Now, the business is showing its latest designs of ... , According to the company’s CEO, all the fresh new ... with big discounts, up to 80% off. All the clothes ...
(Date:1/22/2015)... AZ (PRWEB) January 22, 2015 Padre Murphy's ... long supporter of Pro Player Health Alliance (PPHA). ... Padre Murphy's in getting everyone, including NFL greats, treated for ... of the leading groups supporting the cause in the valley. ...
(Date:1/22/2015)... Minn. (PRWEB) January 22, 2015 Blue Cross ... those Minnesotans who exemplify what it means to “Live Fearless.” ... chance for people to share their stories about how they ... or simply inspired others by living in the moment. By ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... emphasis on preventive care to universal electronic records , ... to debate the details of what many hope will ... health-care system. While no fully formed proposals have emerged ... Evidence-based guidelines. , During a speech to ...
... to Offer Full Integration with Patient and Chamber , ... , world leader in technology for hyperbaric healthcare, today ... System which will provide verification of all NFPA (National Fire ... and is the first to be fully integrated into any ...
... Snapshot of Employer Health Benefits to Help Pharmaceutical and ... Tenn., June 22 HealthLeaders-InterStudy, the leading provider of ... of Employer Vantage , a Web-based ... the nation,s largest employers partner with for health and ...
... ... Free-Standing Inpatient Unit. , ... PA (Vocus) June 22, 2009 -- Peaceful. Calm. Serene. These are the ... Caring for a hospice patient in their own home is ideal, but is not always ...
... HAIKOU CITY, China, June ... (OTC Bulletin Board: CPHI), which develops,manufactures, and markets ... has received official approval from China,s State Food ... Phase II clinical trials to,test the efficacy of ...
... Bioniche Life Sciences Inc. ("Bioniche"; TSX: BNC), a ... update on its corporate activities. , In April, ... in concluding a partnering transaction related to its ... for the intravesical treatment of non-muscle-invasive bladder cancer. ...
Cached Medicine News:Health News:The Nuts and Bolts of Reform Proposals 2Health News:The Nuts and Bolts of Reform Proposals 3Health News:Sechrist Industries Introduces Ground-Check System to Verify NFPA Ground Requirements in Hyperbaric Chambers 2Health News:HealthLeaders-InterStudy Unveils Enhanced Employer Vantage 2Health News:Unique Facility Designed for the Comfort of Hospice Patients and Their Families 2Health News:Unique Facility Designed for the Comfort of Hospice Patients and Their Families 3Health News:China Pharma Holdings, Inc. Announces SFDA Approval for Rosuvastatin Clinical Trials 2Health News:China Pharma Holdings, Inc. Announces SFDA Approval for Rosuvastatin Clinical Trials 3Health News:Bioniche Provides a Corporate Update 2
(Date:1/23/2015)... , Jan. 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... immune therapies for operable and inoperable solid tumor cancers, announced ... the 7 th Annual Phacilitate Immunotherapy Forum in ... at Phacilitate will take place on January 26 at 10:30 ...
(Date:1/23/2015)... NEW YORK , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer ... the board of directors of Advaxis, Inc. ("Advaxis" or ... the board has breached its fiduciary duties to shareholders. ... published on an investing website reporting that Advaxis had ...
(Date:1/23/2015)... Fla. , Jan. 23, 2015  iMD Companies, Inc. (ICBU) ... to increase market share and grab a foothold in the ... influence, production capabilities and a presence in the sector, and ... facilitate the growth of hemp and medical marijuana, iMD is ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: