Navigation Links
Scientists Develop New Strategy to Fight Obesity
Date:10/31/2008

Findings could produce treatments to reduce cravings, expand calorie burn

FRIDAY, Oct. 31 (HealthDay News) -- An antibody that breaks down and suppresses an appetite stimulant produced by the human body has been discovered.

Scientists with The Scripps Research Institute say the antibody catalyst, GHR-11E11, increased the metabolic rate in fasting mice and curbed their eating even after the rodents went 24 hours without food.

The antibody counteracts ghrelin, a gastric hormone that promotes weight gain and fat storage through metabolic actions that decrease the breakdown of stored fat for energy as well as energy expenditure itself. The body releases the substance to encourage eating during periods of calorie restriction. The findings were published in this week's online issue of the Proceedings of the National Academy of Sciences.

"Our study showed that this novel catalytic ghrelin antibody could specifically seek out and degrade ghrelin," co-lead investigator Kim Janda, a professor of chemistry, said in a news release from the institute. "While this antibody lacks a high level of catalytic efficiency, our study clearly demonstrates that even a basal level of catalysis can effectively modulate feeding behavior. These findings not only validate antibody-based therapeutics, but strongly suggest that catalytic anti-ghrelin antibodies might help patients reach and maintain their weight-loss goals."

Because obesity has a complex nature, any antibody-based treatment would likely be combined with other weight-loss strategies, including medicinal, nutritional, exercise, educational and psychosocial components, Janda said. However, he added, more research is needed to better understand the effect of the antibodies over the long-term and other issues.

According to recent reports from the World Health Organization, about 1 billion people worldwide are overweight or obese, with most of these in the
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Develop New Strategy to Fight Obesity
(Date:8/29/2014)... 30, 2014 AGH Healthy Happenings, a ... Doctors in Delaware at Atlantic General Hospital, are ... services. In addition to no-cost blood pressure screenings at ... aid care at local sports tournaments. , In ... staff provide free disease management and falls prevention workshops ...
(Date:8/29/2014)... Daily Gossip reveals in its Get Rid of Cold ... cold sores patient who suffered from this terrible health problem for ... to share her tips and advices, but also her experience with ... the Get Rid of Cold Sores Fast program says that she ... least 4 years outbreaks have become more frequent. , Ellie ...
(Date:8/29/2014)... The new review that can be read ... holistic system that will permanently eliminate the symptoms of this ... can achieve a cure in as fast as 30 to ... only about one week. , The Tinnitus Miracle review ... as mild hearing loss, pain in the ear and dizziness. ...
(Date:8/29/2014)... 29, 2014 The Nasal Polyps ... that the new program is actually based on ... was created by a former nasal polyps sufferer, ... the disturbing problem. Manuel Richards suffered from nasal ... system. , Learn more about Manuel Richards' ...
(Date:8/29/2014)... Indosoft, Inc., a leading provider of ... monthly per-port licensing of its Q-Suite 5.7 software. ... Indosoft has been successfully deploying and supporting its ACD ... centers around the world for more than a decade. ... clients another option which complements the widespread deployment of ...
Breaking Medicine News(10 mins):Health News:Doctors in Delaware from Atlantic General Hospital Offer No-Cost Services to Area Residents 2Health News:Doctors in Delaware from Atlantic General Hospital Offer No-Cost Services to Area Residents 3Health News:Get Rid of Cold Sores Fast Review Reveals Simple Way to Eliminate Cold Sores in 12 Hours 2Health News:Tinnitus Miracle Review Reveals How to Gain Tinnitus Relief in 7 Days 2Health News:Nasal Polyps Treatment Miracle Review Exposes New Natural and Permanent Healing Program 2Health News:Indosoft Offers Monthly Usage Licensing Terms 2
... meat, starches and sweets is linked to a rise ... to a study by US and Chinese researchers released ... the 1990s Shanghai Breast Cancer Study by Vanderbilt University ... between higher incidence of breast cancer and a move ...
... Roche Holding AG says that arthritis drug Actemra has ... helps relieve symptoms of rheumatoid arthritis in difficult-to-treat ... to regulatory approval. ,The Radiate study was conducted ... Actemra was given in combination with a standard treatment ...
... folic acid fortification of enriched grains in the mid 1990s, ... and Canada with neural tube defects has declined by 20 ... institution of fortification, however, the rate at which new cases ... report researchers at the Jean Mayer USDA Human Nutrition Research ...
... hospital ranked as one of Americas Best by U.S. News ... days than those admitted to a non-ranked hospital , according ... of Internal Medicine, one of the JAMA/Archives journals. ... mortality measures that are publicly reported by the Centers for ...
... 9 issue of Archives of Internal Medicine, one of ... screen for prostate cancer are frequently performed among patients ... be beneficial, and clinicians with certain characteristics are more ... ,Most guidelines for clinical practice do not recommend routine ...
... a man of the times, throwing around terms like "eco-design" ... at the Bangkok home he designed for his family two ... only to be energy efficient but to produce energy -- ... of some of the brightest international names working in eco-architecture ...
Cached Medicine News:Health News:Folicacid Fortification Very Beneficial 2Health News:Folicacid Fortification Very Beneficial 3Health News:Americas Best Hospital Reduced Heart Attack Rates 2Health News:Americas Best Hospital Reduced Heart Attack Rates 3Health News:Clinicians Ordering Inappropriate Prostate Screenings 2Health News:Eco-architecture Takes Root in Thailand, but Growth is Slow 2Health News:Eco-architecture Takes Root in Thailand, but Growth is Slow 3
(Date:8/29/2014)... Mass. , Aug. 29, 2014  A ... prospective, multinational study on stent removability and preliminary ... has been published in the August issue of ... multinational study 1 is being conducted in ... of fully covered self-expanding metal stents (FCSEMS) after ...
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "China Orthopedic Instrument Industry Report, 2014-2017" report ... aging population and rising proportion of reimbursement for medical ... effectively released, with its scale presenting a CAGR of ... products are three product segments of orthopedic instruments in ...
(Date:8/29/2014)... 2014 Research and Markets has ... Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018" ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... China,s pharmaceutical equipment industry in the ... landscape, and business performance of domestic major enterprises, as ...
Breaking Medicine Technology:Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4China Orthopedic Instrument Industry Report, 2014-2017 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
... For Landmark Study To Measure Effects Of Music ... Hospital System today announced that it has received ... support a groundbreaking study that will measure the ... patients with diabetes.Lake Hospital System is seeking 200-300 ...
... Technologies Corp. (Nasdaq: BSTC ), a biopharmaceutical ... that BioSpecifics, President, Tom Wegman, will present a corporate ... Health Care Conference on Tuesday, March 17, 2009, at ... Boston, MA. A live webcast of the presentation can ...
Cached Medicine Technology:Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 2Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 3Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: