Navigation Links
Scientists Decode Brain Cancer Cell Line
Date:1/29/2010

Findings could lead to more effective, less toxic treatments, researchers say

FRIDAY, Jan. 29 (HealthDay News) -- The first complete genomic sequencing of a brain cancer cell line has been performed by U.S. scientists.

The achievement may help identify new molecular targets for the development of more effective and less toxic drugs and lead to personalized treatments based on the unique biological signatures of a patient's cancer, according to the team at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles.

The finding also may result in new and better ways to monitor for brain cancer recurrence, as well as a test to determine when brain cancer has been destroyed, which would prevent overtreatment with harmful anti-cancer drugs that can cause long-term health problems.

The sequencing was done on a glioblastoma cell line called U87, which is studied in more than 1,000 laboratories worldwide. The UCLA team used this thoroughly examined brain cancer cell line because the sequencing of its genome will allow scientists who've studied it to reinterpret their findings and perhaps move in new research directions.

According to the report published in the Jan. 29 online edition of the journal PLoS Genetics, with the latest technology, the sequencing of the brain cancer cell line took less than a month and cost about $35,000.

"This is very exciting because we, as scientists, can now move forward with revealing complete cancer genomes," study senior author Dr. Stan Nelson, a professor of human genetics and director of the Jonsson Comprehensive Cancer Center's Gene Expression Shared Resource, said in a news release.

"Cancer is at its heart a genetic disease. Cancer cells have acquired mutations that allow them to invade tissues and to not live by the normal rules. The changes from normal (mutations) that have given the cancer these special properties are encoded in DNA, and the entire DNA sequence has just been too complex and costly to decode until now," Nelson said.

More information

The American Cancer Society has more about brain tumors.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, Jan. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists show how molecular switch helps pancreatic cancer beat drugs
2. Brain scientists extend map of fear memory formation
3. Scientists Turn Mouse Skin Cells Into Nerve Cells
4. Scientists Find Way to Track Flesh-Eating Bacteria
5. Brain Abnormalities in Parkinson's Patients Develop Before Symptoms Occur, According to Feinstein Scientists
6. Scientists shed new light on walking
7. Scientists discover cells critical to childhood leukemia
8. Scientists show how brain tumors outsmart drugs
9. Weizmann Institute scientists reveal how tendons shape developing bones
10. Scripps Research scientists find cancer cells co-opt fat metabolism pathway to become more malignant
11. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... ... LaserShip, a regional parcel carrier that services the eastern U.S., donated and delivered ... order to aid in the Flint water crisis. In 2014, LaserShip acquired Prestige Delivery ... only 15 miles away from Flint. , “We have deep roots in the local ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... unveiling its revolutionary new 2.0 version at the International Roofing Expo in Orlando, ... power of the world's most advanced weather technology in the hands of consumers, ...
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... 2016 , ... Emergency rooms provide emergency care to stabilize critical health issues, ... with dental emergencies at risk of losing a tooth or their smiles. Dr. Marine ... Common dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... CO (PRWEB) , ... February 10, 2016 , ... Dr. ... announce the practice is now accepting new dental patients and families in the North ... exceptional dental care services from cleanings to cosmetic dentistry, and all in the most ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , February 10, 2016 Puerto ... --> Puerto Rico Healthcare and Life Sciences Report 2016 ... 61 page Puerto Rico Healthcare and Life Sciences Report ... insights into the fifth largest territory in the world for ... medical device and diagnostics manufacturing, and more universities per square ...
(Date:2/10/2016)... 10, 2016 CERS ), Medivation, Inc. ... ) and Celldex Therapeutics, Inc. (NASDAQ: CLDX ). ... Adamas Pharmaceuticals, Inc. (NASDAQ: ADMS ) and Celldex Therapeutics, ... Orphan Drug Designations become vitally important in the development of ... drugs and biologics which are defined as those intended for ...
(Date:2/10/2016)... ALBANY, New York , February 10, 2016 ... Share, Growth, Trends and Forecast 2015 - 2023 ", reveals ... a rather slow growth from 2015 to 2023 owing to ... register a meager CAGR of 1.30% during the forecast period, ... 2014 to US$38.9 bn in 2023. --> Antibacterial ...
Breaking Medicine Technology: