Navigation Links
Scientists Decode Brain Cancer Cell Line
Date:1/29/2010

Findings could lead to more effective, less toxic treatments, researchers say

FRIDAY, Jan. 29 (HealthDay News) -- The first complete genomic sequencing of a brain cancer cell line has been performed by U.S. scientists.

The achievement may help identify new molecular targets for the development of more effective and less toxic drugs and lead to personalized treatments based on the unique biological signatures of a patient's cancer, according to the team at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles.

The finding also may result in new and better ways to monitor for brain cancer recurrence, as well as a test to determine when brain cancer has been destroyed, which would prevent overtreatment with harmful anti-cancer drugs that can cause long-term health problems.

The sequencing was done on a glioblastoma cell line called U87, which is studied in more than 1,000 laboratories worldwide. The UCLA team used this thoroughly examined brain cancer cell line because the sequencing of its genome will allow scientists who've studied it to reinterpret their findings and perhaps move in new research directions.

According to the report published in the Jan. 29 online edition of the journal PLoS Genetics, with the latest technology, the sequencing of the brain cancer cell line took less than a month and cost about $35,000.

"This is very exciting because we, as scientists, can now move forward with revealing complete cancer genomes," study senior author Dr. Stan Nelson, a professor of human genetics and director of the Jonsson Comprehensive Cancer Center's Gene Expression Shared Resource, said in a news release.

"Cancer is at its heart a genetic disease. Cancer cells have acquired mutations that allow them to invade tissues and to not live by the normal rules. The changes from normal (mutations) that have given the cancer these special properties are encoded in DNA, and the entire DNA sequence has just been too complex and costly to decode until now," Nelson said.

More information

The American Cancer Society has more about brain tumors.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, Jan. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists show how molecular switch helps pancreatic cancer beat drugs
2. Brain scientists extend map of fear memory formation
3. Scientists Turn Mouse Skin Cells Into Nerve Cells
4. Scientists Find Way to Track Flesh-Eating Bacteria
5. Brain Abnormalities in Parkinson's Patients Develop Before Symptoms Occur, According to Feinstein Scientists
6. Scientists shed new light on walking
7. Scientists discover cells critical to childhood leukemia
8. Scientists show how brain tumors outsmart drugs
9. Weizmann Institute scientists reveal how tendons shape developing bones
10. Scripps Research scientists find cancer cells co-opt fat metabolism pathway to become more malignant
11. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment ... Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... General Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: