Navigation Links
Scientists Decode Brain Cancer Cell Line
Date:1/29/2010

Findings could lead to more effective, less toxic treatments, researchers say

FRIDAY, Jan. 29 (HealthDay News) -- The first complete genomic sequencing of a brain cancer cell line has been performed by U.S. scientists.

The achievement may help identify new molecular targets for the development of more effective and less toxic drugs and lead to personalized treatments based on the unique biological signatures of a patient's cancer, according to the team at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles.

The finding also may result in new and better ways to monitor for brain cancer recurrence, as well as a test to determine when brain cancer has been destroyed, which would prevent overtreatment with harmful anti-cancer drugs that can cause long-term health problems.

The sequencing was done on a glioblastoma cell line called U87, which is studied in more than 1,000 laboratories worldwide. The UCLA team used this thoroughly examined brain cancer cell line because the sequencing of its genome will allow scientists who've studied it to reinterpret their findings and perhaps move in new research directions.

According to the report published in the Jan. 29 online edition of the journal PLoS Genetics, with the latest technology, the sequencing of the brain cancer cell line took less than a month and cost about $35,000.

"This is very exciting because we, as scientists, can now move forward with revealing complete cancer genomes," study senior author Dr. Stan Nelson, a professor of human genetics and director of the Jonsson Comprehensive Cancer Center's Gene Expression Shared Resource, said in a news release.

"Cancer is at its heart a genetic disease. Cancer cells have acquired mutations that allow them to invade tissues and to not live by the normal rules. The changes from normal (mutations) that have given the cancer these special properties are encoded in DNA, and the entire DNA sequence has just been too complex and costly to decode until now," Nelson said.

More information

The American Cancer Society has more about brain tumors.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, Jan. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists show how molecular switch helps pancreatic cancer beat drugs
2. Brain scientists extend map of fear memory formation
3. Scientists Turn Mouse Skin Cells Into Nerve Cells
4. Scientists Find Way to Track Flesh-Eating Bacteria
5. Brain Abnormalities in Parkinson's Patients Develop Before Symptoms Occur, According to Feinstein Scientists
6. Scientists shed new light on walking
7. Scientists discover cells critical to childhood leukemia
8. Scientists show how brain tumors outsmart drugs
9. Weizmann Institute scientists reveal how tendons shape developing bones
10. Scripps Research scientists find cancer cells co-opt fat metabolism pathway to become more malignant
11. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) announced ... Act of 1976, as amended ("HSR"), with respect to ... CPXX ) expired effective June 24, 2016, ... previously announced on May 31, 2016, Jazz Pharmaceuticals and ... Jazz Pharmaceuticals has commenced a tender offer for all ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: