Navigation Links
Scientists Create New Means to Study Disease Origins
Date:12/24/2008

Availability of rat stem cells may help link genes to human disorders,,

WEDNESDAY, Dec. 24 (HealthDay News) -- The first embryonic stem (ES) cells from rats have been derived by University of Southern California researchers, who said their success will enable the creation of far more effective animal models to study a wide range of human diseases.

"This is a major development in stem cell research because we know that rats are much more closely related to humans than mice in many aspects of biology," principal investigator Qi-Long Ying, an assistant professor of cell and neurobiology at the Keck School of Medicine, said in a university news release. "The research direction of many labs around the world will change because of the availability of rat ES cells."

The ability to derive rat ES cells advances efforts to create rats for use in biomedical research that are genetically modified to lack one or more genes. The ability to observe what happens to an animal when specific genes are removed helps scientists pinpoint the function of genes and whether they're associated with specific diseases.

"The availability of rat ES cells will greatly facilitate the creation of rat models for the study of different human diseases, such as cancer, diabetes, high blood pressure, addiction and autoimmune diseases," said Ying, who is also a researcher at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the university.

The first ES cell lines from mice were created in 1981, and researchers have long been trying to establish rat ES cells. But conventional methods developed for deriving mouse ES cells didn't work in rats. The research team finally found a laboratory-based way to grow rat stem cells indefinitely in the primitive embryonic state.

The research appears in the Dec. 26 issue of Cell.

In another study published in the same issue of the journal, a team led by researchers at the University of Cambridge in England report similar findings. This provides independent verification that authentic ES cells can be established from rats.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



University of Southern California, news release, Dec. 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists reveal structure of new botulism nerve toxin subtype
2. Scientists Discover Trigger for Autoimmune Diseases
3. Scientists Spot Key to Cystic Fibrosis Infections
4. Scientists, Physicians, Health, and Environmental Justice Advocates to New Obama EPA Director: We Look Forward to Toxic Chemical Regulatory Reform
5. Seven life scientists get research boost to set up in Europe
6. UC San Diego scientists developing brain imaging methods for studying natural human behavior
7. Scientists ID Enzyme Causing Brain Cell Death
8. NASA scientists provide update on existing remote sensing technology programs and new projects
9. Scientists ID Protein Aiding Breast Cancer Spread
10. UCLA scientists prove endothelial cells give rise to blood stem cells
11. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
Breaking Medicine Technology: