Navigation Links
Scientists Close in on Origins of Psoriasis, Eczema
Date:7/20/2011

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, July 20 (HealthDay News) -- Psoriasis and eczema both cause red, scaly skin rashes, but the similarities between the two common, distressing conditions typically end there.

And now, examining patients suffering from both ailments (a very rare phenomenon), German scientists have teased out the opposing immune system responses that prompt skin flare-ups for both diseases.

They believe the findings could one day lead to more targeted, effective treatments.

The study, published in the July 21 issue of the New England Journal of Medicine, evaluated three patients with both psoriasis and eczema and noted that the T-cells -- types of white blood cells that fight infection -- found in psoriasis lesions differed from those found in eczema lesions.

The findings suggest that these T-cells migrate to the skin in response to distinct environmental triggers, not that the skin cells themselves are abnormal in either inflammatory condition, the study authors said.

"It's just another way for doctors to understand immune pathways and where they go awry," explained Dr. Doris Day, a dermatologist at Lenox Hill Hospital in New York City, who was not involved in the study. "It puts our understanding exponentially ahead and confuses us at the same time, because it's not supposed to happen [that patients can have both conditions]. The study definitely has value, and they're not making any claims or recommendations."

The most prevalent autoimmune disease in the United States, psoriasis affects up to 7.5 million Americans and is thought to arise from a combination of genetic and environmental triggers, according to the National Psoriasis Foundation. Eczema, on the other hand, is thought to be an allergic response and often occurs simultaneously in those with asthma or food allergies, according to the American Academy of Allergy, Asthma and Immunology. It is often outgrown by adulthood.

Psoriasis lesions in the study participants contained large numbers of so-called Th1 and Th17 cells, whereas eczema lesions had higher amounts of Th2 and Th22 cells. The researchers expanded their testing to include five patients with psoriasis and skin allergies to nickel -- a much more common combination that prompts an eczema-like reaction -- to confirm a similar T-cell response to psoriasis.

The study also found that all eczema lesions, but none in psoriasis, harbored Staphylococcus aureus bacteria, confirming that T-cells in psoriasis appear to prompt an innate immune response that's different from what is seen in eczema.

Dr. Jerry Bagel, a spokesman for the National Psoriasis Foundation and associate clinical professor of dermatology at Columbia University in New York City, said the research indicates that eczema and psoriasis "are clearly distinct entities, but there is some crossover immunologically."

If scientists could determine which antigens stimulate each condition -- a job that would likely take years -- they might find new ways to stop the disorders from developing in predisposed people, Bagel and Day agreed.

Current psoriasis treatments, which include both topical and systemic drugs, aim to suppress the body's immune response and slow down the skin cell growth cycle that leads to its trademark red, scaly plaques. Eczema treatments can involve both medications and lifestyle changes that cut itching, inflammation and worsening of the condition.

But, perhaps in the future, "they could have more direct testing to see if patients have an immune system alteration," Day said. "The more we understand the pathways and how the immune system responds to insults from the external world . . . we can adjust steps along the way, or medications that minimize side effects and maximize safety."

More information

Find out more about eczema and psoriasis at the International Eczema-Psoriasis Foundation.

SOURCES: Doris Day, M.D., dermatologist, Lenox Hill Hospital, New York City; Jerry Bagel, M.D., spokesman, National Psoriasis Foundation, director, Psoriasis Treatment Center of Central New Jersey, East Windsor, N.J., and associate clinical professor, dermatology, Columbia University, New York City; July 21, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Close in on Origins of Psoriasis, Eczema 
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent ... as the number one company for hearing aids, ranking it ... fifteen other brands. ... Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, ...
Breaking Medicine Technology: