Navigation Links
Scientists Capture HIV Transfer Among T-Cells on Video
Date:3/27/2009

Team suggests there are many targets now for interfering with the process

FRIDAY, March 27 (HealthDay News) -- The transfer of HIV from infected to uninfected immune system T-cells has been captured on video for the first time, in an achievement that could lead to new ways to block the transmission of HIV, researchers say.

"Most prior studies of HIV dissemination have focused on free- roaming viruses, but this study shows us how direct T-cell-to-T-cell contact could, in fact, be the predominant mode of dissemination within the body," Dr. Benjamin Chen, an assistant professor of medicine and infectious diseases at Mount Sinai School of Medicine in New York City, said in a school news release.

The team of researchers from Mount Sinai and from the University of California, Davis, Center for Biophotonics Science and Technology discovered that HIV moves between T-cells through structures called virological synapses.

"Direct T-cell-to-T-cell transfer through virological synapses is a highly efficient avenue of HIV infection. Our recent experiments show that the viral structural protein moves with surprising speed in infected cells, and that the cell machinery actively participates in the transport of virus between T-cells. This suggests there are many targets for interfering with the process," Chen said.

To capture the transfer of HIV from T-cell to T-cell on video, the researchers created a molecular clone on infectious HIV that contained a green fluorescent jellyfish protein. Quantitative, high-speed, 3D video microscopy was used to record both viral particle formation and HIV transmission between T-cells.

"We found that the transfer of HIV is highly coordinated between T-cells, and that the transfer is rapid and massive. Future efforts to block HIV transmission may be designed to specifically exploit and block this cell-to-cell mode of infection," Chen said.

The study appears in the March 27 issue of Science.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV transmission.



-- Robert Preidt



SOURCE: Mount Sinai School of Medicine, news release, March, 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Capture HIV Transfer Among T-Cells on Video
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: