Navigation Links
Scientists Capture HIV Transfer Among T-Cells on Video
Date:3/27/2009

Team suggests there are many targets now for interfering with the process

FRIDAY, March 27 (HealthDay News) -- The transfer of HIV from infected to uninfected immune system T-cells has been captured on video for the first time, in an achievement that could lead to new ways to block the transmission of HIV, researchers say.

"Most prior studies of HIV dissemination have focused on free- roaming viruses, but this study shows us how direct T-cell-to-T-cell contact could, in fact, be the predominant mode of dissemination within the body," Dr. Benjamin Chen, an assistant professor of medicine and infectious diseases at Mount Sinai School of Medicine in New York City, said in a school news release.

The team of researchers from Mount Sinai and from the University of California, Davis, Center for Biophotonics Science and Technology discovered that HIV moves between T-cells through structures called virological synapses.

"Direct T-cell-to-T-cell transfer through virological synapses is a highly efficient avenue of HIV infection. Our recent experiments show that the viral structural protein moves with surprising speed in infected cells, and that the cell machinery actively participates in the transport of virus between T-cells. This suggests there are many targets for interfering with the process," Chen said.

To capture the transfer of HIV from T-cell to T-cell on video, the researchers created a molecular clone on infectious HIV that contained a green fluorescent jellyfish protein. Quantitative, high-speed, 3D video microscopy was used to record both viral particle formation and HIV transmission between T-cells.

"We found that the transfer of HIV is highly coordinated between T-cells, and that the transfer is rapid and massive. Future efforts to block HIV transmission may be designed to specifically exploit and block this cell-to-cell mode of infection," Chen said.

The study appears in the March 27 issue of Science.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV transmission.



-- Robert Preidt



SOURCE: Mount Sinai School of Medicine, news release, March, 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Capture HIV Transfer Among T-Cells on Video
(Date:1/19/2017)... ... January 19, 2017 , ... ... Atlanta Breast Surgery Symposium, a conference where hundreds of surgeons from over fifteen ... surgery. Covering topics from cosmetic breast augmentation to breast reconstruction for ...
(Date:1/18/2017)... ... 18, 2017 , ... From a health perspective, 2017 will clearly be the ... to chronic disease, mental health and general physical well-being. The New York Times suggested ... consider. , For one Charlottesville restaurant, good gut health is clearly on the menu. ...
(Date:1/18/2017)... ... January 18, 2017 , ... The V Foundation for Cancer Research, a ... endurance training and fundraising team, to compete in the Boston Marathon on April 17. ... finish the world’s oldest annual marathon to join Team V and support the Foundation’s ...
(Date:1/18/2017)... , ... January 18, 2017 , ... At Hallmark Nameplate, ... announce that they have achieved certification to ISO 13485. This certification is another way ... up to date products and services that they need. , The ISO 13485 Certification ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... of the revolutionary Active Brake Technology (ABT), an innovative braking system that allows ... Active Brake Technology addresses one of the biggest concerns of beginner and intermediate ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017 Invetech, the ... cell and advanced therapies , has announced a ... company developing "tumor starvation" treatments for acute leukemia ... Under the agreement, Invetech will develop systems to ... Erytech,s proprietary ERYCAPS technology platform, which uses a ...
(Date:1/18/2017)... January 18, 2017 ML ... plans to publish an online presentation tomorrow, January ... sales forecast for 2017. Management reports that the ... record sales performance from its existing operations, and ... entry into the Cannabis sector through a ...
(Date:1/18/2017)... Authority Chinese Food and Drug Administration CSL ... Institute Food and Drug Administration FORT ... Glaxo Smith Klein GlaxoWellcome Global Influenza ... Immune Targeting Systems Indian Association of ... Johnson & Johnson Krka Pharmaceuticals Medicago ...
Breaking Medicine Technology: