Navigation Links
Scientists Capture HIV Transfer Among T-Cells on Video
Date:3/27/2009

Team suggests there are many targets now for interfering with the process

FRIDAY, March 27 (HealthDay News) -- The transfer of HIV from infected to uninfected immune system T-cells has been captured on video for the first time, in an achievement that could lead to new ways to block the transmission of HIV, researchers say.

"Most prior studies of HIV dissemination have focused on free- roaming viruses, but this study shows us how direct T-cell-to-T-cell contact could, in fact, be the predominant mode of dissemination within the body," Dr. Benjamin Chen, an assistant professor of medicine and infectious diseases at Mount Sinai School of Medicine in New York City, said in a school news release.

The team of researchers from Mount Sinai and from the University of California, Davis, Center for Biophotonics Science and Technology discovered that HIV moves between T-cells through structures called virological synapses.

"Direct T-cell-to-T-cell transfer through virological synapses is a highly efficient avenue of HIV infection. Our recent experiments show that the viral structural protein moves with surprising speed in infected cells, and that the cell machinery actively participates in the transport of virus between T-cells. This suggests there are many targets for interfering with the process," Chen said.

To capture the transfer of HIV from T-cell to T-cell on video, the researchers created a molecular clone on infectious HIV that contained a green fluorescent jellyfish protein. Quantitative, high-speed, 3D video microscopy was used to record both viral particle formation and HIV transmission between T-cells.

"We found that the transfer of HIV is highly coordinated between T-cells, and that the transfer is rapid and massive. Future efforts to block HIV transmission may be designed to specifically exploit and block this cell-to-cell mode of infection," Chen said.

The study appears in the March 27 issue of Science.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV transmission.



-- Robert Preidt



SOURCE: Mount Sinai School of Medicine, news release, March, 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Capture HIV Transfer Among T-Cells on Video
(Date:2/11/2016)... Washington, DC (PRWEB) , ... February 11, 2016 ... ... announce an upcoming Feb. 23 webinar, “Intel’s Direct-to-Employee Benefit Model: A Case Study ... a not-for-profit Catholic health care system that’s partnering with Intel on value-based health ...
(Date:2/11/2016)... Mount Laurel, NJ (PRWEB) , ... February 11, ... ... Commission) announces the call for nominations seeking candidates for the Board of Commissioners. ... individuals with passion, skills and experience with diversity of clinical practice settings and ...
(Date:2/11/2016)... ... , ... PharmMD CEO Robert Yeager announced today ... contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will include healthcare ... breaches for the Part D Star Rating improvement and Medication Therapy Management firm. ...
(Date:2/11/2016)... ... 11, 2016 , ... Greenfield Insurance Group in Orange City, ... the people of their local community. The agency pledges to select a new ... hope is to bring awareness to important local causes with fundraising and other ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... and updated its hallmark resource, Infusion Therapy Standards of Practice, to include vascular ... vein illumination with an estimated 85% share of the market, facilitates adherence to ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... YORK , Feb. 11, 2016 ... instruments commonly used in laboratories. These may range from ... condensers. Laboratory glassware is made from borosilicate glass because ... Laboratory plasticware, on the other hand, started gaining popularity ... it was easier to replace glass with plastic in ...
(Date:2/11/2016)... Feb. 11, 2016   Health 2.0 , the ... health technologies, announced today " 10 Year Global Retrospective ... tech over the past ten years.   ... decade, Health 2.0 has served as the preeminent thought-leader ... with thousands of technologies, companies, innovators, and patient-activists through ...
(Date:2/11/2016)... , Feb. 11, 2016 AAIPharma Services ... of custom manufacturing and development services for the ... fill-finish capabilities and capacity in its ... demand has driven several recent investments. ... had one filling line with small-scale lyophilization. The ...
Breaking Medicine Technology: