Navigation Links
Scientists Break Into HIV 'Hideout'
Date:5/28/2008

Vault for antibodies provides shelter for virus out of reach of drugs

WEDNESDAY, May 28 (HealthDay News) -- Researchers have confirmed that a certain type of cell provides a "hideout" for HIV during drug treatment and is a reservoir of HIV in humans.

These follicular dendritic cells (FDCs) are located throughout the body in specialized sites known as lymphoid tissues, said researchers at Brigham Young University and Johns Hopkins School of Medicine.

FDCs act as "vaults" to store material needed to maintain the immune system's legions of antibodies. When there's a drop in a particular kind of antibody, FDCs release proteins that trigger an immune response to increase levels of those antibodies.

The researchers discovered that FDCs have such an effective vault mechanism that HIV can remain out of reach of drugs flowing through the blood stream. This finding that FDCs harbor HIV may help scientists find ways to attack HIV taking shelter in these reservoir cells.

The study was expected to be published in the June issue of the Journal of Virology.

"One of the biggest obstacles in treating patients with HIV is the establishment of these reservoirs that resist treatment," principal investigator Greg Burton, a BYU biochemistry professor, said in a prepared statement. "The ability to understand the virus in these reservoirs, and to characterize the reservoir itself, provides information with which we can begin to try to devise strategies that target the virus in these reservoirs."

Previous research has shown that two other types of cells -- macrophages and latently infected CD4+ T-cells -- are reservoirs of HIV. It was suspected that FDCs also acted as HIV reservoirs, and this new study confirmed that suspicion.

More information

The National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Brigham Young University, news release, May 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in post-acute health care, have expanded their existing home health joint venture through ... AccentCare has been operating a joint venture home health company with Asante, delivering ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
Breaking Medicine Technology: