Navigation Links
Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Date:9/17/2012

JUPITER, FL, September 13, 2012 A scientist from the Florida campus of The Scripps Research Institute has been awarded a pair of grants totaling $2.8 million from the National Institute of General Medical Sciences of the National Institutes of Health, and from TargAnox, a Massachusetts-based biotechnology firm.

Kate Carroll, a Scripps Research associate professor, will be the principal investigator for the new projects.

Research funded by both grants will focus on a process known sulfenylation, a relatively new field of research. During periods of cellular stress, caused by factors such as UV radiation or chronic diseases such as cancer, the level of highly reactive oxygen-containing molecules can increase, resulting in inappropriate modification of proteins and cell damage through this process. One oxidant produced naturally in the body, hydrogen peroxide, acts as a messenger that can activate cell proliferation.

In the new research, Carroll will look at cell signaling in sulfenylation and explore ways that it might be modified with potential drug compounds to treat conditions such as lung and breast cancers, as well as be used to diagnose and monitor such diseases.

To explore the process, Carroll and her colleagues have developed a highly selective chemical probeknown as DYn-2 that can detect minute differences in sulfenylation rates within the cell. The new four-year, approximately $1.5 million NIH grant (award number 1R01GM102187-01) will fund work utilizing that chemical probe to fully define the molecular mechanism through which a key signaling protein, epidermal growth factor receptor (EGFR), is modified by hydrogen peroxide.

"The grant from NIH will let us take a closer look at the basic mechanics of the sulfenylation process and detail how oxidation regulates EGFR," Carroll said. "The TargAnox study uses that work as a spring board into potential treatments."

Carroll said she also plans to investigate additional targets of sulfenylation and to test various compounds that can reverse the process.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Kessler Foundation scientist garners best poster award for MS research
2. Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat
3. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
4. Scientists Spot 5 Genes That Help Shape Faces
5. Eight scientists honored in first annual Golden Goose Awards
6. Scientists Map Genetic Blueprint of Heart
7. Scientists use sound waves to levitate liquids, improve pharmaceuticals
8. UCF nanoscientist receives $2 million NIH award
9. Scientists ID Gene for Insulin Sensitivity
10. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
11. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: