Navigation Links
Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Date:9/17/2012

JUPITER, FL, September 13, 2012 A scientist from the Florida campus of The Scripps Research Institute has been awarded a pair of grants totaling $2.8 million from the National Institute of General Medical Sciences of the National Institutes of Health, and from TargAnox, a Massachusetts-based biotechnology firm.

Kate Carroll, a Scripps Research associate professor, will be the principal investigator for the new projects.

Research funded by both grants will focus on a process known sulfenylation, a relatively new field of research. During periods of cellular stress, caused by factors such as UV radiation or chronic diseases such as cancer, the level of highly reactive oxygen-containing molecules can increase, resulting in inappropriate modification of proteins and cell damage through this process. One oxidant produced naturally in the body, hydrogen peroxide, acts as a messenger that can activate cell proliferation.

In the new research, Carroll will look at cell signaling in sulfenylation and explore ways that it might be modified with potential drug compounds to treat conditions such as lung and breast cancers, as well as be used to diagnose and monitor such diseases.

To explore the process, Carroll and her colleagues have developed a highly selective chemical probeknown as DYn-2 that can detect minute differences in sulfenylation rates within the cell. The new four-year, approximately $1.5 million NIH grant (award number 1R01GM102187-01) will fund work utilizing that chemical probe to fully define the molecular mechanism through which a key signaling protein, epidermal growth factor receptor (EGFR), is modified by hydrogen peroxide.

"The grant from NIH will let us take a closer look at the basic mechanics of the sulfenylation process and detail how oxidation regulates EGFR," Carroll said. "The TargAnox study uses that work as a spring board into potential treatments."

Carroll said she also plans to investigate additional targets of sulfenylation and to test various compounds that can reverse the process.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Kessler Foundation scientist garners best poster award for MS research
2. Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat
3. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
4. Scientists Spot 5 Genes That Help Shape Faces
5. Eight scientists honored in first annual Golden Goose Awards
6. Scientists Map Genetic Blueprint of Heart
7. Scientists use sound waves to levitate liquids, improve pharmaceuticals
8. UCF nanoscientist receives $2 million NIH award
9. Scientists ID Gene for Insulin Sensitivity
10. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
11. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
(Date:5/2/2016)... ... , ... This week Omega Institute, a premier nonprofit educational retreat center in ... Omega is offering a record 370 in-person workshops and new online learning opportunities ... interest in or need for the knowledge and skills we’ve been cultivating for nearly ...
(Date:5/2/2016)... ... 02, 2016 , ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed roster was announced ... the cut. The WUGC is being held in London, England this year from June 18-25. ... men’s division, another gold in the women’s masters division, and a silver in the women’s ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... and urgent care facilities designed to automate and improve the rapid diagnosis, triage ... it is demonstrating their platform, application, and mobile experience for the first time ...
(Date:5/2/2016)... ... May 02, 2016 , ... MedaCheck, a leading medication ... outcomes, has announced its partnership with GrandView Health Services. , With decades of ... counter and prescription drug pharmacy services to thousands of residents. Serving Indiana, Ohio, ...
(Date:5/2/2016)... TN (PRWEB) , ... May 02, 2016 , ... ... and behavioral health services, today announced the opening of Twin Lakes Recovery Center. ... will be Summit’s first in the state. The residential facility is set ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... NEW YORK , April 28, 2016 /PRNewswire/ ... will notably complement the company,s valve repair and ... the move also places Abbott more firmly into ... one of the fastest growing device areas, with ... to its recent report,  Advanced Remote Patient ...
(Date:4/28/2016)... Calif. , April 28, 2016  Marking ... widely accessible breast and ovarian cancer risk test, ... panel analyzing 30 genes that highly impact the ... women. Available today, the Color Test analyzes hereditary ... prostate, stomach, and uterine cancers. The Color Test ...
(Date:4/28/2016)... , April 28, 2016  The blood testing market ... dollars, according to Kalorama Information and The Freedonia Group ... and nucleic acid testing.  The healthcare research firm said ... in developing blood collection stations and in improving testing ... Kalorama Information,s report, Blood Testing Market in ...
Breaking Medicine Technology: