Navigation Links
Scientist creates new cancer drug that is 10 times more potent
Date:8/29/2012

COLUMBIA, Mo. -- Legend has it that Ralph Waldo Emerson once said, "Build a better mousetrap, and the world will beat a path to your door." University of Missouri researchers are doing just that, but instead of building mousetraps, the scientists are targeting cancer drugs. In a new study, MU medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer, added a special structure to it, and created a more potent, efficient weapon against cancer.

"Over the past decade, we have seen an increasing interest in using carboranes in drug design," said Mark W. Lee Jr., assistant professor of chemistry in College of Arts and Science. "Carboranes are clusters of three elements boron, carbon and hydrogen. Carboranes don't fight cancer directly, but they aid in the ability of a drug to bind more tightly to its target, creating a more potent mechanism for destroying the cancer cells."

In the study, Lee and his research team used carboranes to build new drugs designed to shut off a cancer cell's energy production, which is vital for the cell's survival. All cells produce energy through complex, multi-step processes. The key to an effective drug is targeting the process that cancer cells depend on more than healthy cells. By increasing the binding strength of a drug, a smaller dose is required, minimizing side effects and increasing the effectiveness of the therapy. With carboranes, Lee found that the drug is able to bind 10 times more powerfully.

"The reason why these drugs bind stronger to their target is because carboranes exploit a unique and very strong form of hydrogen bonding, the strongest form of interactions for drugs," Lee said.

Lee said that this discovery also will lead to further uses for the drug.

"Too often, after radiation or chemotherapy, cancer cells repair themselves and reinvade the body," Lee said. "This drug not only selectively shuts off the energy pro
'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientist creates new cancer drug that is 10 times more potent
(Date:8/1/2014)... 01, 2014 Over 20,000 entrepreneurs from ... the 2014 Market America | SHOP.COM International Convention at ... The annual event will introduce new products, technology, programs ... earning, and also feature a who’s who of celebrities. ... | SHOP.COM Executive Team, successful entrepreneurs and celebrity guests. ...
(Date:8/1/2014)... FL (PRWEB) August 01, 2014 Fitness is ... too much effort. From walking around the block to biking ... to do and easy to maintain throughout the year. The ... a fitness forward series which will feature special guests, tips ... and stay in shape. The series will air on most ...
(Date:8/1/2014)... August 01, 2014 We are ... ES-AMI on AWS Marketplace. EspressReport ES-AMI delivers enterprise ... at $0.50 per hour (AWS infrastructure charges apply). ... easy-to-use enterprise BI and operational reporting system with ... and ad hoc reporting. It allows users to ...
(Date:8/1/2014)... Register to join the webinar here: http://bit.ly/1lPZNI9 . ... record for life sciences investing. IPOs in the sector tripled ... all venture dollars spent in 2013. The result: biotech companies ... However, 2014 is proving more of a mixed bag of ... while life sciences IPOs are losing steam, M&A is expected ...
(Date:7/31/2014)... Serious buyer, Andrew Hawley, announces his search ... Owsley Bear Stanley, the King of Acid, created the ... to Hawley, “The Grateful Dead and Owsley teamed up ... San Francisco and Los Angeles in 1965. The 1965 ... of paper. They were a goldenrod yellow, blue, and ...
Breaking Medicine News(10 mins):Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 2Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 3Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 4Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 5Health News:Forbes Living to Air Fitness Forward Series 2Health News:Quadbase Systems Inc. Announces The Availability Of It’s Flagship Enterprise Reporting, Dashboard and BI Analytics Tool on Amazon’s AWS Marketplace 2Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 2Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 3
... surgeon John J. Callaghan, MD was elected to the Board ... ( http://www.aaos.org/ )(AAOS) at the organization,s 2009 Annual Meeting ... First Vice-President.Having to wear a cast as a young child, ... the field of orthopaedic surgery. "Breaking my arm taught ...
... time for ACL injuries in young athletesLAS VEGAS, Feb. ... Ligament (ACL) tears occur in the United States. ... Meeting of the American Academy of Orthopaedic Surgeons ... seen in younger patients as an increasing number of ...
... 25 February 2009 Molecular Oncology ... behalf of the Federation of European Biochemical Societies ... ISI), for inclusion in the Science Citation Index ... , MOLONC (published 6 times a year ...
... 25 The National Hospice and Palliative Care Organization ... Out" grants. Funded by the Department of Veterans Affairs, ... hospice and palliative care services for rural and homeless ... represent a range of community-based organizations. These providers ...
... Products Completely Safe, Include No Ingredients from PCA -NEW YORK, ... not affected by the Peanut Corporation of America (PCA) recall, ... any variety of KIND Fruit + Nut Bars or KIND ... that PCA is the focus of their investigation concerning a ...
... intergenerational program developed by OASIS to enlist older adults ... to eight cities during the next two years with ... promotes physical activity and healthy eating for low-income children ... grades 3 to 5 in after-school settings using teams ...
Cached Medicine News:Health News:John J. Callaghan, MD Elected Academy First Vice President 2Health News:John J. Callaghan, MD Elected Academy First Vice President 3Health News:An Athlete's First Question: 'Doc, When Can I Return?' 2Health News:An Athlete's First Question: 'Doc, When Can I Return?' 3Health News:Molecular Oncology accepted into Thomson Reuters index 2Health News:Grants to Increase Access to Hospice and Palliative Care for Rural and Homeless Veterans Awarded by National Hospice and Palliative Care Organization 2Health News:KIND Snacks Unaffected by Peanut Butter Recall 2Health News:WellPoint Foundation Awards Grants to OASIS to Expand Unique Active Generations Program 2Health News:WellPoint Foundation Awards Grants to OASIS to Expand Unique Active Generations Program 3
(Date:7/31/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ... of its lead molecule, Anatabine Citrate, in ... Clinical, The Translational Pharmaceutics Company, based in the ... early development programs. The Company expects to ... of the third quarter with the Medicines Healthcare products ...
(Date:7/31/2014)... 31, 2014 Touro University California,s College of ... as the recipient of a $150,000 grant by the ... University to increase research and classroom space on its ... for the study of health sciences, and will help ... and interests of our students," said Shelley Berkley ...
(Date:7/31/2014)... July 31, 2014 Catylix, Inc. ( ... ( Milpitas, California ) announced today ... and commercialize new fluorination products and related chemistry. ... benefited from the use of substituents that are ... with polarity to improve binding and bioavailability. Fluorinated ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2
... mental retardation, birth defects, and autism spectrum and ... in New YorkMADISON, N.J., March 17 Quest ... world,s leading provider of diagnostic testing, information and ... genomic hybridization (aCGH) postnatal test is now available ...
... Inc. announced today that it has achieved proof ... Inhibiting Multiple Pathways) kinase platform by designing a ... of both the PI3K (Phosphoinositide-3-kinase) pathway and the ... SF2626 has demonstrated the ability to inhibit both ...
Cached Medicine Technology:Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 2Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 3Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 4Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: