Navigation Links
Scientist creates new cancer drug that is 10 times more potent
Date:8/29/2012

COLUMBIA, Mo. -- Legend has it that Ralph Waldo Emerson once said, "Build a better mousetrap, and the world will beat a path to your door." University of Missouri researchers are doing just that, but instead of building mousetraps, the scientists are targeting cancer drugs. In a new study, MU medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer, added a special structure to it, and created a more potent, efficient weapon against cancer.

"Over the past decade, we have seen an increasing interest in using carboranes in drug design," said Mark W. Lee Jr., assistant professor of chemistry in College of Arts and Science. "Carboranes are clusters of three elements boron, carbon and hydrogen. Carboranes don't fight cancer directly, but they aid in the ability of a drug to bind more tightly to its target, creating a more potent mechanism for destroying the cancer cells."

In the study, Lee and his research team used carboranes to build new drugs designed to shut off a cancer cell's energy production, which is vital for the cell's survival. All cells produce energy through complex, multi-step processes. The key to an effective drug is targeting the process that cancer cells depend on more than healthy cells. By increasing the binding strength of a drug, a smaller dose is required, minimizing side effects and increasing the effectiveness of the therapy. With carboranes, Lee found that the drug is able to bind 10 times more powerfully.

"The reason why these drugs bind stronger to their target is because carboranes exploit a unique and very strong form of hydrogen bonding, the strongest form of interactions for drugs," Lee said.

Lee said that this discovery also will lead to further uses for the drug.

"Too often, after radiation or chemotherapy, cancer cells repair themselves and reinvade the body," Lee said. "This drug not only selectively shuts off the energy pro
'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientist creates new cancer drug that is 10 times more potent
(Date:12/20/2014)... MissyDress, a distinguished special dress supplier, has just done ... drastically cut prices to all its prom dresses already, ... 2015. Many of the hottest styles are sold here ... and more. , A spokesman for MissyDress says, “The ... princess prom dresses or sweetheart chiffon prom dresses, you ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... that allege a metal-on-metal version of the artificial ... forward in state and federal courts, Bernstein Liebhard ... New Jersey’ Bergen County Superior Court on December ... permitted to begin deposition of plaintiffs on November ...
(Date:12/20/2014)... The Doctor’s Office Urgent Care of Paramus, New Jersey ... decade. They’ve treated over 40,000 patients while carrying out ... alternative to the Paramus area. , For 2015, the ... staff of top-notch board certified physicians: Christine Milosis MD, Sandra ... new doctors will work tirelessly to carry out The ...
(Date:12/20/2014)... The aftermath of the November 24th hack on Sony ... Hollywood, but worldwide. As reported in the Los ... attack are starting a finger-pointing game which could put some ... are not the only ones affected, regular employees who had ... times ahead, agents and lawyers could be in for some ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The Twin ... protection education event in the nation! Over 250 financial ... the minute information on the industry, get motivated to ... of real people facing and overcoming the challenges of ... all across the nation came together to attend The ...
Breaking Medicine News(10 mins):Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3
... finds screening infants helps decrease chance of early arthritis , ... the most common congenital defect in newborns. The condition occurs when a ... with the condition are often at risk of developing arthritis ... study published in the July 2009 issue of The Journal ...
... Christian Children,s Fund, one of the world,s oldest and largest ... takes effect today. , , The name ChildFund ... the needs of children today and tomorrow. ChildFund International has ... family members in 31 countries. , , "The ...
... NASHVILLE, Tenn., July 1 Zografia, a leading design ... award from the Nashville chapter of AIGA, the professional ... graphic design and celebrate the relationship between businesses and ... businesses to successfully communicate to their targeted audiences. , ...
... , , Unified Blue Cross Blue Shield Brand Strengthens Competitive ... Virgin Islands , , ... (NYSE: GTS ) today announced that Triple-S Salud, ... certain managed care assets of La Cruz Azul de Puerto Rico, Inc. ...
... Pro-Health Enamel Shield toothpaste creates a micro-thin shield against acid ... Leading women,s health expert, Donnica L. Moore, MD, wants women ... overall wellness. She recommends Crest and Oral-B Pro-Health products ... into a daily health regimen. , , (Photo: ...
... Reduce Medical Identity Theft , , CHESAPEAKE, Va., July ... provider of data enhancement, verification, and communication Web services, announced ... prepare for enforcement of the Federal Trade Commission,s Red ... ) , , According to the FTC Web site, ...
Cached Medicine News:Health News:Infants Should Be Screened for Hip Trouble 2Health News:Infants Should Be Screened for Hip Trouble 3Health News:Christian Children's Fund Name Change to ChildFund International Official 2Health News:Triple-S Management Corporation Completes Acquisition of La Cruz Azul de Puerto Rico, Inc. 2Health News:Triple-S Management Corporation Completes Acquisition of La Cruz Azul de Puerto Rico, Inc. 3Health News:Triple-S Management Corporation Completes Acquisition of La Cruz Azul de Puerto Rico, Inc. 4Health News:Dr. Donnica Moore Advocates that Women Follow a Preventive Dental Health Routine that Includes Crest Pro-Health Enamel Shield 2Health News:Dr. Donnica Moore Advocates that Women Follow a Preventive Dental Health Routine that Includes Crest Pro-Health Enamel Shield 3Health News:CDYNE XML Web Services Help Organizations Comply with FTC Red Flags Rule 2Health News:CDYNE XML Web Services Help Organizations Comply with FTC Red Flags Rule 3
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
(Date:12/19/2014)... has witnessed robust development with the growth pace keeping at ... In 2012, the size of China ... worldwide soaring to 16.3%. It is projected that ... rate by around 20% in the upcoming years and that ... An integrated membrane industrial system has taken shape ...
(Date:12/17/2014)... 17, 2014 Los beneficios y ... alto nivel de gasto en investigación y desarrollo   ... el 30 de septiembre de 2014) ZEISS aumentó sus ... de euros (año anterior: 4.190 millones de euros) a ... ganancias (EBIT) crecieron un 14 por ciento, a 360 ...
Breaking Medicine Technology:Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3ZEISS confirma su posición en un entorno difícil 2
... Ekkyo(TM), a photomedicine,company that develops first-in-class laser-based systems for skin ... of EkkyLite(TM), its assessment through some key figures: , , ... EkkyLite(TM) system, - Almost 200 patients have been ... the operating room, - 10 French centres are ...
... BALTIMORE CONVENTION CENTER / BOOTH #616 - ... department (ED) clinical documentation solutions, today announced that its ... electronic Emergency Department Information System (EDIS) incorporates the latest ... diagnosis and treatment of H1N1, as well as the ...
Cached Medicine Technology:Ekkyo Presents a Positive Assessment one Year After the Launch of EkkyLite(TM), its New Scar Healing System 2Ekkyo Presents a Positive Assessment one Year After the Launch of EkkyLite(TM), its New Scar Healing System 3Latest Content Release for The T SystemEV EDIS Supports Clinicians in Providing Quality Care for H1N1 Patients 2Latest Content Release for The T SystemEV EDIS Supports Clinicians in Providing Quality Care for H1N1 Patients 3
... is designed to give accurate and ... neurosurgical intensive care, trauma, and operating ... and easy to use, and provides ... built-in audible alarm alerts attending staff ...
A portable, easy to use, dual-channel laser-Doppler tissue perfusion and temperature monitoring system, at a remarkably affordable price....
... highly featured laser doppler system for ... from multiple tissue sites. This latest ... Signal Processing (DSP) and laser Doppler ... simple to use, multi-channel monitor, setting ...
... highly featured laser doppler system for ... from multiple tissue sites. This latest ... Signal Processing (DSP) and laser Doppler ... simple to use, multi-channel monitor, setting ...
Medicine Products: