Navigation Links
Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
Date:4/4/2012

JUPITER, FL, April 4, 2012 Scientists from the Florida campus of The Scripps Research Institute have been awarded just over $1 million from the National Institutes of Health for a three-year study to develop new high-throughput screening tests to find compounds that disable a protein essential to hepatitis C virus (HCV) replication.

Timothy Tellinghuisen, a Scripps Florida associate professor, is the principal investigator for the study.

Hepatitis C is a slow-progressing disease that causes inflammation of the liver and affects some 170 million people worldwide, according to the Hepatitis Foundation International. Like the current approach to HIV/AIDS, a cocktail-based therapeutic approach, which uses multiple inhibitors targeting distinct aspects of the HCV life cycle, has emerged as one of the most promising.

In the search for new treatments against HCV, it has become critical to develop novel targets to attack.

Tellinghuisen's new research is focused on a potentially potent, but somewhat neglected, enzyme. This proteasean enzyme that breaks down proteinsis known as NS2, which is necessary for productive infections that produce new viruses and spread the infection among cells.

"The NS2 protein is needed for hepatitis C infections, but is poorly understood," Tellinghuisen said. "The new grant will help us develop potential chemical tools to look at the role of NS2 in HCV biology because we really don't know how the protein works."

Some recent studies suggest that the NS2 protease may be involved in altering gene expression in the host cell and in helping the virus defend against apoptosis or programmed cell death, in addition to the more direct roles for the protein in viral replication and particle assembly.

Tellinghuisen and his colleagues have already developed a small-scale screen to identify compounds that disrupt viral replication through NS2 protease activity.

"Our overall goal is to turn our small-scale NS2 assay into an assay appropriate for high-throughput small-molecule screening," he said, noting that would give the team access to the more expansive Molecular Libraries Probe Production Centers Network (MLPCN) screening center program at Scripps Florida.

MLPCN is a collaborative research network that uses use high-tech screening methods to identify small molecules to investigate the diverse functions of cells; Scripps Research is one of four large national centers.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Mensa GLAAM Conference to Feature Christian Drapeau, Stem Cell Author and Scientist
5. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
6. Scientists find donut-shaped structure of enzyme involved in energy metabolism
7. Neuroscientists reveal new links that regulate brain electrical activity
8. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
9. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
10. Scientists Spot Genetic Fingerprints of Individual Cancers
11. AADR awards the 2010 Distinguished Scientist Award to John Greenspan
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub some ... to Perry A~, author of “Calcium Bentonite Clay” the health benefits of integrating clay ... and detoxifying the body. , A former motivational speaker, Perry A~ has since dedicated ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... greater than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth ... ”It is time to make a change in public health,” states Carole Baggerly, ...
(Date:2/8/2016)... ... ... Guruji Mahendra Kumar Trivedi is offering 3 days of accelerated personal growth ... on February 10th. During this time, people can achieve better health, greater wealth, ... from over 40 different countries as an “ordinary man with an extraordinary gift.” ...
(Date:2/7/2016)... Birmingham, Lake Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, ... ... women on Friday in recognition of National Wear Red Day. National Wear Red ... heart disease and stroke in women. Heart disease and stroke cause 1 in 3 ...
(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... US Sports ... Coaching Conference (YUCC) . This event brings together top non-profit leaders, ultimate organizations, and ... and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and Education, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016  Dynatronics Corporation (NASDAQ: DYNT ... devices and rehabilitation equipment for the physical therapy, ... Broncos, football team for winning the 2016 World ... Chairman and Chief Executive Officer.  "The Broncos have ... forward to enhancing their athletic achievements with our ...
(Date:2/8/2016)... , February 8, 2016 ... report published by Allied Market Research titled, "World ... and Forecasts, 2014-2020", estimates the world synthetic biology ... synthesis and sequencing technology segment would continue to ... software tools segment, collectively, held around half of ...
(Date:2/5/2016)... OAKS, Calif. , Feb. 5, 2016 Amgen ... 5 th Annual Global Healthcare Conference at 9:15 a.m. ... York City . David W. Meline , executive ... at the conference. Live audio of the presentation can be ... , under Investors. A replay of the webcast will also ...
Breaking Medicine Technology: