Navigation Links
Scientific hunch poised to save thousands from toxic fish poisoning
Date:10/21/2008

A neuroscientist at UQ's Queensland Brain Institute has found a way to combat a debilitating illness that affects an estimated 50,000 people a year in tropical regions.

Ciguatera poisoning which often results in acute nausea, vomiting and painful gastrointestinal episodes is caused by eating fish that have fed on a micro algae that are toxic to mammals and often associated with large algal blooms known as red tides.

Cases of ciguatera poisoning have been documented for more than 200 years and were recorded and described by Captain Cook on his second voyage to the Pacific in 1774.

Recently, scientists have discovered that the patented compound brevenal could be used to make an effective treatment for neurotoxic shellfish poisoning (NSP), a condition related to ciguatera poisoning.

Acting initially on a hunch, QBI neuroscientist Associate Professor Fred Meunier hypothesised that brevenal could be adapted to combat ciguatera poisoning.

Simultaneously, and unbeknown to Dr Meunier, Dr Dan Baden at the University of North Carolina Wilmington (USA) was also considering adapting brevenal to fight ciguatera.

The two scientists soon became aware of each other's interest and began discussing the possibility that the compound active against NSP could have the same therapeutic effect on ciguatera toxins.

Along with Dr Dan Baden, Dr Jordi Molgo (National Center For Scientific Research, France) and Dr Richard Lewis at UQ's Institute for Molecular Bioscience, Dr Meunier pressed on to obtain a small batch of both ciguatera toxin and brevenal to test their hypothesis.

"It now seems that we have found a way of blocking the effect of the ciguatera toxin on sodium channels without affecting their function of propagating the electrical signals in neurons," Dr Meunier said.

One of the main problems with ciguatera is that there are few, if any, effective treatments for the acute impact it has on the health of humans and marine mammals.

"There is one drug available for ciguatera sufferers but a randomised trial conducted by another research group in 2002 found it to be no better than a placebo," Dr Meunier said.

Armed with the knowledge of how the ciguatera toxin affects the body, Dr Meunier and his research collaborators are now looking to develop a drug that will short-circuit the ciguatera toxin's effect in mammals. The process of synthesising and safely delivering the drug for human patients will require extensive trials.


'/>"/>

Contact: QBI Communications
r.hohen@uq.edu.au
61-733-466-414
Research Australia
Source:Eurekalert

Related medicine news :

1. Milestone Scientific Announces Successful Completion of its Collaboration Agreement With Carticept Medical
2. Thomson Scientific Predicts Nobel Laureates
3. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
4. Thomson Scientific Announces BONDplus for Biological Researchers
5. Milestone Scientific Commences Declaratory Judgment Action With Respect to Its Single Tooth Anesthesia (STA(TM)) System and Compudent(TM) System
6. International Society of Hair Restoration Surgery Hosts 15th Annual Scientific Meeting in Las Vegas, September 26-30, 2007
7. Milestone Scientific Names Robert Presutti New Vice President of Sales and Marketing
8. Thomson Scientific Signs Multi-Year Agreement with The Council for Scientific and Industrial Research (CSIR)
9. Heart Failure Society of America 11th Annual Scientific Meeting to Focus on Heart Failure Guidelines, Innovation and New Research
10. Milestone Scientific to Exhibit the STA(TM) System at the American Dental Associations 148th Annual Session in San Francisco
11. Delta Dental Plans Association Forms National Scientific Advisory Committee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... June 23, 2016  Experian Health, the ... transforming the patient payment and care experience, ... new products and services that will enhance ... cycle offerings. These award-winning solutions will enable ... remain compliant in an ever-changing environment and ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: