Navigation Links
Scientific hunch poised to save thousands from toxic fish poisoning
Date:10/21/2008

A neuroscientist at UQ's Queensland Brain Institute has found a way to combat a debilitating illness that affects an estimated 50,000 people a year in tropical regions.

Ciguatera poisoning which often results in acute nausea, vomiting and painful gastrointestinal episodes is caused by eating fish that have fed on a micro algae that are toxic to mammals and often associated with large algal blooms known as red tides.

Cases of ciguatera poisoning have been documented for more than 200 years and were recorded and described by Captain Cook on his second voyage to the Pacific in 1774.

Recently, scientists have discovered that the patented compound brevenal could be used to make an effective treatment for neurotoxic shellfish poisoning (NSP), a condition related to ciguatera poisoning.

Acting initially on a hunch, QBI neuroscientist Associate Professor Fred Meunier hypothesised that brevenal could be adapted to combat ciguatera poisoning.

Simultaneously, and unbeknown to Dr Meunier, Dr Dan Baden at the University of North Carolina Wilmington (USA) was also considering adapting brevenal to fight ciguatera.

The two scientists soon became aware of each other's interest and began discussing the possibility that the compound active against NSP could have the same therapeutic effect on ciguatera toxins.

Along with Dr Dan Baden, Dr Jordi Molgo (National Center For Scientific Research, France) and Dr Richard Lewis at UQ's Institute for Molecular Bioscience, Dr Meunier pressed on to obtain a small batch of both ciguatera toxin and brevenal to test their hypothesis.

"It now seems that we have found a way of blocking the effect of the ciguatera toxin on sodium channels without affecting their function of propagating the electrical signals in neurons," Dr Meunier said.

One of the main problems with ciguatera is that there are few, if any, effective treatments for the acute impact it has on the health of humans and marine mammals.

"There is one drug available for ciguatera sufferers but a randomised trial conducted by another research group in 2002 found it to be no better than a placebo," Dr Meunier said.

Armed with the knowledge of how the ciguatera toxin affects the body, Dr Meunier and his research collaborators are now looking to develop a drug that will short-circuit the ciguatera toxin's effect in mammals. The process of synthesising and safely delivering the drug for human patients will require extensive trials.


'/>"/>

Contact: QBI Communications
r.hohen@uq.edu.au
61-733-466-414
Research Australia
Source:Eurekalert

Related medicine news :

1. Milestone Scientific Announces Successful Completion of its Collaboration Agreement With Carticept Medical
2. Thomson Scientific Predicts Nobel Laureates
3. Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)
4. Thomson Scientific Announces BONDplus for Biological Researchers
5. Milestone Scientific Commences Declaratory Judgment Action With Respect to Its Single Tooth Anesthesia (STA(TM)) System and Compudent(TM) System
6. International Society of Hair Restoration Surgery Hosts 15th Annual Scientific Meeting in Las Vegas, September 26-30, 2007
7. Milestone Scientific Names Robert Presutti New Vice President of Sales and Marketing
8. Thomson Scientific Signs Multi-Year Agreement with The Council for Scientific and Industrial Research (CSIR)
9. Heart Failure Society of America 11th Annual Scientific Meeting to Focus on Heart Failure Guidelines, Innovation and New Research
10. Milestone Scientific to Exhibit the STA(TM) System at the American Dental Associations 148th Annual Session in San Francisco
11. Delta Dental Plans Association Forms National Scientific Advisory Committee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... 23, 2017 , ... Thomas Vas-Don suffered from severe injury due ... was able to successfully recover. In “ Origin & Insertion Charts for Massage Therapists ... the principals of massage, anatomy , trigger points and referral pain patterns ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Gevir, a ... deer antler velvet, announced its products are coming soon to Amazon.com, the world’s largest ... Shelley Thomson as a means to develop an effective natural treatment for Shelley’s Multiple ...
(Date:2/22/2017)... ... , ... The National Academy of Certified Care Managers (NACCM) ... testing period. NACCM, a nonprofit organization, has provided the premier certification for Care ... re-calibrated to ensure that newly certified professionals are prepared to work effectively on ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... with chronic conditions reported skipping doses or not filling a prescription because they ... under-insured, rates of cost-related problems getting medications were 30-60%*. At the ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified ... from the mouth into the bloodstream. Far outpacing the absorption speed ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... MARIETTA, Ga., Feb. 23, 2017  MiMedx Group, Inc. ... amniotic tissue and patent-protected processes to develop and market ... Orthopedic, Spine, Sports Medicine, Ophthalmic, and Dental sectors of ... quarter and full year ended December 31, 2016. ... Revenue is a 31% increase over full year ...
(Date:2/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Cardiac Prosthetic ... 9.2% over the next decade to reach approximately $8.9 billion by ... forecasts for all the given segments on global as well as ...
(Date:2/23/2017)... 23, 2017  Spheryx, Inc. will present ... at PittCon 2017 Conference and Exposition at ... world,s largest annual premier conference and exposition ... array of industry, academic and government communities ... food safety, environmental, bioterrorism and other emerging ...
Breaking Medicine Technology: