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Scientific Journal Gene Therapy Reports That Cardium's Gene Activated Matrix Technology Accelerates Periodontal Tissue Regeneration
Date:9/14/2009

ieved from having viable teeth. With an estimated 69% of adults ages 35 to 44 having lost at least one permanent tooth to an accident, gum disease, a failed root canal, or tooth decay, dental implants represent a large market. By age 74, 26% of adults have lost all of their permanent teeth and this population is growing as the number of Americans over 55 is expected to increase by 60% in the next 20 years.

In 2006, the combined U.S. market for dental bone graft substitutes and other biomaterials was valued at slightly over $150 million. This market includes bone graft substitutes, tissue engineering products, and dental membranes. The market is expected to rapidly grow as the number of bone graft procedures associated with dental implants increases. Market is expected to increase to over $415 million by 2013.

About Cardium

Cardium is focused on the acquisition and strategic development of new and innovative bio-medical product opportunities and businesses that have the potential to address significant unmet medical needs and definable pathways to commercialization, partnering and other economic monetizations. Cardium's investment portfolio includes the Tissue Repair Company and Cardium Biologics, medical technology companies primarily focused on the development of innovative therapeutic products for tissue repair and cardiovascular indications. In May 2009, Cardium announced completion of the enrollment for the Matrix Phase 2b clinical study to evaluate the Excellarate product candidate as a treatment for patients with non-healing diabetic ulcers. News from Cardium is located at www.cardiumthx.com.

Forward-Looking Statements

Except for statements of historical fact, the matters discussed in this press release are forward looking and reflect numerous
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SOURCE Cardium Therapeutics
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