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Scientific Journal Gene Therapy Reports That Cardium's Gene Activated Matrix Technology Accelerates Periodontal Tissue Regeneration
Date:9/14/2009

The preclinical study demonstrated that the initial response to a bolus administration of rhPDGF-BB protein was strong, but the short half-life of the protein results in rapid degradation with a decrease in the mitogenic response. In contrast, PDGF-B gene delivery using Cardium's Gene Activated Matrix technology resulted in sustained protein expression that lasted for approximately 14 days. The benefits of this prolonged availability are expected to be even more evident in planned large animal critical size defect models. The study also reported that there was no dissemination of the AdPDGF-B vector away from the treatment site, and no alteration of hematological and clinical chemistry parameters associated with the AdPDGF-B/collagen treatments. The authors conclude that, "This approach shows the ability of Ad-PDGF-B to accelerate oral implant osseointegration. The data support the concept that Ad-PDGF-B gene delivery may be an effective and safe mode of therapy comparable with PDGF-BB application to promote dental implant osseointegration and oral bone repair."

"The results of this preclinical study demonstrate the potential benefits of our GAM technology for bone engineering and oral implant osseointegration and further support our decision to expand the focus of the Company's regenerative medicine technologies to include orthobiologics," reported Christopher J. Reinhard, Chairman and Chief Executive Officer of Cardium Therapeutics and Tissue Repair Company. "Cardium's Gene Activated Matrix technology and protein-producing gene portfolio are important building blocks as we expand our product development programs from wound healing biologics into the emerging new high growth market segment of orthobiologics."

Orthobiologics Product Platform

The Company recently announced plans to develop a DNA-based orthobiologics product portfolio based on research and development by Cardium's Tissue Repa
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SOURCE Cardium Therapeutics
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