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Scientific Journal Gene Therapy Reports That Cardium's Gene Activated Matrix Technology Accelerates Periodontal Tissue Regeneration
Date:9/14/2009

SAN DIEGO, Sept. 14 /PRNewswire-FirstCall/ -- Cardium Therapeutics (NYSE Amex: CXM) today reported on preclinical findings published in the scientific journal, Gene Therapy, demonstrating that Cardium's Gene Activated Matrix(TM) or GAM(TM) technology accelerates periodontal tissue regeneration of oral implant-supporting wounds. The PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration study (Chang, et al., Gene Therapy; 10 September 2009; doi: 10.1038/gt.2009.117) conducted by researchers at the University of Michigan is available online at nature.com/doifinder/10.1038/gt.2009.117, and reports on the use of AdPDGF-B/collagen (the key component of the Company's Excellarate(TM) product candidate) to promote oral implant osseointegration. The study's findings demonstrate that AdPDGF-B/collagen is safe, accelerates and enhances oral implant osseointegration, and leads to significantly higher bone-implant contact, defect fill, bone area and tissue mineral density than placebo.

(Logo:http://www.newscom.com/cgi-bin/prnh/20051018/CARDIUMLOGO)

Oral implants are widely accepted in dental medicine as a reconstructive treatment for tooth replacement due to disease, injury or congenital defects. Growth factor application has been advocated to improve osteogenesis and osseointegration, however, as a result of the transient action and short half-life of proteins, the sustained bioavailability associated with growth factor gene delivery has been proposed as an effective alternative for the delivery of growth factor proteins.
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