Navigation Links
Science Translational Medicine: 'Creating Hope Act' incentivizes pediatric drug R&D
Date:1/19/2011

Washington, DC Recent legislative and regulatory actions make great strides toward establishing much needed incentives for pharmaceutical companies and others to develop and test more medications for pediatric rare diseases, including pediatric cancers, according to commentary by experts from Children's National Medical Center. The commentary appears in the January 19 issue of Science Translational Medicine.

"Pediatricians who treat children with serious and life-threatening diseases often find themselves face to face with the inadequacies of pediatric drug development," write Edward Connor, MD, director of the Office of Innovation Development and Investigational Therapeutics at Children's National Medical Center, and Pablo Cure, MD, MPH, Laboratory for Entrepreneurial Achievement in Pediatrics (LEAP) Scholar in the Office of Innovation Development and Investigational Therapeutics.

In a previous commentary for this journal, Dr. Connor noted that despite the fact that children make up nearly 40 percent of the world's population, little research is done to test the effects of "adult therapies" on children, who have unique needs requiring tailored care more sophisticated than merely smaller doses of adult therapeutics. The demand for pediatric drugs, especially those for rare diseases like childhood cancer, is relatively low compared to the demand for adult drugs, as fewer children develop rare and serious illnesses. To maximize efficacy and return on investment, pharmaceutical developers sometimes focus their efforts on therapeutics that address illnesses common to larger populations.

Pediatric specialists frequently have to prescribe therapeutics for children "off-label" because many common drugs and devices for treating diseases are only tested in adults but are necessary for the treatment of children. Research, however, has shown repeatedly that drugs and devices for adults can impact children differently.

According to the authors, the Creating Hope Act of 2010 that is pending before Congress recognizes the importance of stimulating pediatric drug development. It updates the existing Priority Voucher for Neglected Diseases Program to include rare and serious diseases of childhood. That program offers a financial incentive to companies developing drugs for neglected diseases.

"Although government support is critical," the authors continued, "it is not sufficient to produce productsfor use in children. Incentive programs like the Creating Hope Act and other approaches designed to motivate drug development for children are also needed. Our investment in biomedical research is providing returns, and we need to assure that children, the most vulnerable among us, benefit from this investment as well."


'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Related medicine news :

1. Dartmouth Medical School faculty named fellows of the American Association for the Advancement of Science
2. New Society for Social Neuroscience to help guide emerging field
3. fMRI special section of Perspectives on Psychological Science
4. Fresh Seafood Shouldnt Smell Fishy, Food Science Expert Says
5. Dr. Oliver Daumke of MDC wins Bayer Early Excellence in Science Award
6. Professor John Shine wins 2010 Prime Ministers Prize for Science
7. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
8. Saturday news tips: Resuscitation Science Symposium
9. Yerkes researchers present at 40th Annual Society for Neuroscience Conference
10. Academies of science call for amendments to impracticable Genetic Diagnostics Act
11. Louisiana State University Health Sciences Center research shows fish oil component given up to 5 hours after stroke limits brain damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Shark Finds and Kevin Harrington, and the Product ... GRIP-DRY. , GRIP-DRY is a newly patented product that has solved some of the basic ... wet and early morning dew or right after a rain shower, might understand the struggle ...
(Date:2/8/2016)... ... February 08, 2016 , ... CURE Media Group , the ... the Multiple Myeloma Heroes Awards event , which will annually honor individuals making ... patients with MM. The MM Heroes Awards nomination process is officially open ...
(Date:2/8/2016)... PA (PRWEB) , ... February 08, 2016 , ... ... expanded authorization with BASF Human Nutrition into the Food & Beverage ... BSI has been BASF’s channel partner throughout Canada and USA geographies east of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, serving ... a new charity campaign. As part of their ongoing community involvement program, funds ... belief that children deserve a voice, and in the spirit of neighbors helping ...
(Date:2/8/2016)... ... ... who has struggled to quit smoking, a man who has struggled with hair loss – ... his problems – and he did. Now Nabat, a serial entrepreneur featured as the October ... to the world and better people's lives. His own experience with nicotine addiction led to ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Johnson & Johnson (NYSE: ... Markets Global Healthcare Conference on Tuesday, Feb. 23, at ... Dominic Caruso , Vice President, Finance & Chief Financial ... will represent the Company in a session scheduled at ... --> www.investor.jnj.com . --> This ...
(Date:2/9/2016)...  The Parenteral Drug Association, Inc. (PDA), the ... sterile drug products, today announced the publication of ... With link to Comparison Spreadsheet. The document ... FDA, the EU, the Pharmaceutical Inspection Convention/Scheme and ... --> PDA,s Global Sterile Task ...
(Date:2/8/2016)... 2016 Aesthetic Devices - Medical Devices Pipeline ... report, "Aesthetic Devices - Medical Devices Pipeline Assessment, 2015" ... stage. This report is prepared using ... by GlobalData,s team of industry experts. *Note: Certain ... based on the availability and relevance of data in ...
Breaking Medicine Technology: