Navigation Links
Schizophrenia study finds cognitive deficits significantly impair decision-making capacity
Date:8/9/2011

221.10.254.64

(Garrison, NY) Concern about the capacity of individuals with schizophrenia to consent to clinical research studies has largely focused on impairment due to psychotic symptoms associated with the disorder. Less attention has been given to the cognitive errors that prospective participants make when undergoing a formal assessment of decisional capacity.

In a study reported in IRB: Ethics & Human Research, a team of psychiatrists and clinical psychologists found that errors due to cognitive difficulties were common. For example, 65.5 percent of individuals undergoing the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) made errors resulting from difficulty recalling study information and 22.6 percent overemphasized the potential for personal gain from study participation.

Individuals' "responses were also notable for the errors they did not make," the researchers noted. "Ethical concerns have been raised surrounding the notion that psychotic symptoms per se (e.g., delusional thinking) might impede the capacity for decision-making. However, in the present analyses, no evidence supports detrimental effects of psychosis on decisional capacity for research participation among this outpatient sample."

Additionally, 90.5 percent of participants understood that the study was voluntary after hearing the study information only once. When the information was repeated, all but one participant understood the voluntary nature. "Despite concerns regarding the potential for coercion, the fact that the vast majority of participants in the present study recognized the voluntary nature of participation suggests that perceived coercion is uncommon," the researchers commented.

Based on their findings, the researchers identified ways to increase the likelihood that individuals with schizophrenia will make informed decisions about participating in research. Though 55 of the 84 participants made errors in recalling study information, repetition of relevant information led to perfect or nearly perfect recall in 36.4 percent of them; 47.3 percent had improvements in recall, though they continued to miss important details. The researchers concluded that "given difficulties some individuals have with recalling information conveyed during the consent process, key study information should be highlighted and repeated to them."

As this study was limited to stable outpatients with mild to moderate psychiatric symptoms, the results cannot be extrapolated to inpatient or acutely ill populations.


'/>"/>

Contact: Michael Turton
turtonm@thehastingscenter.org
845-424-4040 x242
The Hastings Center
Source:Eurekalert

Related medicine news :

1. Why symptoms of schizophrenia emerge in young adulthood
2. Mothers flu during pregnancy may increase babys risk of schizophrenia
3. Working-Memory Gene Linked to Schizophrenia
4. Scientists find gene linked to schizophrenia
5. Cold sore virus may contribute to cognitive and brain abnormalities in schizophrenia
6. Brain signs of schizophrenia found in babies
7. New book offers cutting-edge perspective on causes of schizophrenia; related disorders
8. EEG predicts response to medication for schizophrenia
9. Combining medication and psychosocial treatments may benefit patients with early-stage schizophrenia
10. Ming T. Tsuang recognized with NARSAD outstanding achievement award for schizophrenia research
11. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The Dianne Michael Insurance ... in Hamilton County, is embarking on a charity drive with the aim of ... homes for orphaned or neglected senior dogs in the Cincinnati region, and LuvFurMutts ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... Coppin Insurance ... owners and families in and around the Cape Coral area, is embarking on a ... Food Bank of Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... families and business owners in and around central Kansas, is joining the Youth ... youth in the region. , Headquartered in Wichita, Youth Horizons works to empower ...
(Date:12/7/2016)... ... December 07, 2016 , ... "Today, MHA ... most comprehensive mental health systems reform legislation in more than fifty years. We ... the commitment of our elected officials to improving mental health services and supports ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... and deep lines by smoothing and tightening the skin of the face to ... to address facial aging with very little downtime, Silhouette Instalift is a novel, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
(Date:12/8/2016)... , Dec. 8, 2016  A new study ... that the use of opioid therapy to treat chronic ... the likelihood of more harmful consequences, including death. ... M.D., and Zankhana Mehta , M.D., authored the ... on chronic opioid therapy. The study was published in ...
(Date:12/8/2016)... 2016 Information products and services provider ... Scopus , the world,s largest abstract and citation database of ... for journals from over 5,000 publishers. The new set of metrics ... to and when to adjust a journal,s editorial strategy. ... , , ...
Breaking Medicine Technology: