Navigation Links
Schizophrenia study finds cognitive deficits significantly impair decision-making capacity
Date:8/9/2011

221.10.254.64

(Garrison, NY) Concern about the capacity of individuals with schizophrenia to consent to clinical research studies has largely focused on impairment due to psychotic symptoms associated with the disorder. Less attention has been given to the cognitive errors that prospective participants make when undergoing a formal assessment of decisional capacity.

In a study reported in IRB: Ethics & Human Research, a team of psychiatrists and clinical psychologists found that errors due to cognitive difficulties were common. For example, 65.5 percent of individuals undergoing the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) made errors resulting from difficulty recalling study information and 22.6 percent overemphasized the potential for personal gain from study participation.

Individuals' "responses were also notable for the errors they did not make," the researchers noted. "Ethical concerns have been raised surrounding the notion that psychotic symptoms per se (e.g., delusional thinking) might impede the capacity for decision-making. However, in the present analyses, no evidence supports detrimental effects of psychosis on decisional capacity for research participation among this outpatient sample."

Additionally, 90.5 percent of participants understood that the study was voluntary after hearing the study information only once. When the information was repeated, all but one participant understood the voluntary nature. "Despite concerns regarding the potential for coercion, the fact that the vast majority of participants in the present study recognized the voluntary nature of participation suggests that perceived coercion is uncommon," the researchers commented.

Based on their findings, the researchers identified ways to increase the likelihood that individuals with schizophrenia will make informed decisions about participating in research. Though 55 of the 84 participants made errors in recalling study information, repetition of relevant information led to perfect or nearly perfect recall in 36.4 percent of them; 47.3 percent had improvements in recall, though they continued to miss important details. The researchers concluded that "given difficulties some individuals have with recalling information conveyed during the consent process, key study information should be highlighted and repeated to them."

As this study was limited to stable outpatients with mild to moderate psychiatric symptoms, the results cannot be extrapolated to inpatient or acutely ill populations.


'/>"/>

Contact: Michael Turton
turtonm@thehastingscenter.org
845-424-4040 x242
The Hastings Center
Source:Eurekalert

Related medicine news :

1. Why symptoms of schizophrenia emerge in young adulthood
2. Mothers flu during pregnancy may increase babys risk of schizophrenia
3. Working-Memory Gene Linked to Schizophrenia
4. Scientists find gene linked to schizophrenia
5. Cold sore virus may contribute to cognitive and brain abnormalities in schizophrenia
6. Brain signs of schizophrenia found in babies
7. New book offers cutting-edge perspective on causes of schizophrenia; related disorders
8. EEG predicts response to medication for schizophrenia
9. Combining medication and psychosocial treatments may benefit patients with early-stage schizophrenia
10. Ming T. Tsuang recognized with NARSAD outstanding achievement award for schizophrenia research
11. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... 2017 , ... "At your fingertips" electronic access to patient ... Delaware Health Information Network (DHIN) have partnered to improve connectivity of this data ... exchange, DHIN stores and shares real-time health data for more than 2 million ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, ... in the industry, according to the recent NEJM Catalyst Insights Report on the ... the NEJM Catalyst Insights Council, a qualified group of U.S. executives, clinical leaders, ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter ... Show on the Pet Life Radio network. The episode, which was posted this ... topics including: what factors led to Park Cities Pet Sitter’s being awarded the 2017 ...
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a ... Davidson, NC. Dr. Brian Seese leads the practice as a skilled and highly credentialed ... roof. Smiles by Seese serves patients of all ages with excellence in general, restorative, ...
(Date:2/17/2017)... ... February 17, 2017 , ... Wells Pharmacy Network ... prescribing of controlled and non-controlled substances plus the ability to manage orders on ... United States now accept electronic prescriptions, according to the Office of the National ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017 Provides understanding and access to ... into by the worlds leading healthcare companies. ... Description The Global Renal Failure Partnering Terms and ... to partnering deals and agreements entered into by ... Trends in partnering deals - Top deals ...
(Date:2/20/2017)... 20, 2017 The report analyzes the worldwide markets for Drug-Eluting ... the US, Canada , Japan ... Latin America , and Rest of World. ... ... provided for the period 2015 through 2022. Also, a six-year historic ...
(Date:2/20/2017)... Feb. 20, 2017 This report analyzes the worldwide ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , and Rest ... http://www.reportlinker.com/p04707131-summary/view-report.html Annual estimates and forecasts are provided ... analysis is provided for these markets. Market data and analytics ...
Breaking Medicine Technology: