Navigation Links
Schizophrenia linked to signaling problems in new brain study
Date:3/3/2009

Schizophrenia could be caused by faulty signalling in the brain, according to new research published today in the journal Molecular Psychiatry. In the biggest study of its kind, scientists looking in detail at brain samples donated by people with the condition have identified 49 genes that work differently in the brains of schizophrenia patients compared to controls.

Many of these genes are involved in controlling cell-to-cell signalling in the brain. The study, which was carried out by researchers at Imperial College London and GlaxoSmithKline, supports the theory that abnormalities in the way in which cells 'talk' to each other are involved in the disease.

Schizophrenia is thought to affect around one in 100 people. Symptoms vary but can include hallucinations, lack of motivation and impaired social functioning. The disorder has little physical effect on the brain and its causes are largely unknown.

Some scientists believe that schizophrenia could be caused by the brain producing too much dopamine, partly because drugs that block dopamine action provide an effective treatment for the condition. Another theory is that the coat surrounding nerve cells, which is made of myelin, is damaged in people with schizophrenia. However, the new study found that the genes for dopamine and for myelin were not acting any differently in schizophrenia patients compared with controls.

Professor Jackie de Belleroche, the corresponding author of the paper from Imperial College London said: "The first step towards better treatments for schizophrenia is to really understand what is going on, to find out what genes are involved and what they are doing. Our new study has narrowed the search for potential targets for treatment."

As well as pointing towards signalling as the cause of schizophrenia, the new findings could also lead to new ways of diagnosing the condition. At the moment, patients are diagnosed on the basis of their b
'/>"/>

Contact: Lucy Goodchild
lucy.goodchild@imperial.ac.uk
44-020-759-46712
Imperial College London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe
2. New Research Study in Houston, Texas Seeks Improved Quality of Life for People in the Future with Schizophrenia
3. Genome Study Points to New Culprit for Schizophrenia
4. Johns Hopkins researchers discover new schizophrenia gene
5. Altered brain activity in schizophrenia may cause exaggerated focus on self
6. People With Schizophrenia Say Bias Is Part of Their Lives
7. Common Genes Link Bipolar Disorder, Schizophrenia
8. Compound Tied to Cognitive Deficits in Schizophrenia
9. Glutamate: Too much of a good thing in schizophrenia?
10. Anti-inflammatory medications may become a treatment for schizophrenia
11. New candidate genes for schizophrenia identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Phoenix, AZ (PRWEB) December 25, 2014 ... comes to outstanding customer service and affordable quality regarding ... metropolitan area announces recognition in 2014 by the “Queen ... and Sons has earned an impressive reputation over the ... pricing on a wide range of contractor services for ...
(Date:12/24/2014)... Connie Casad, MD, a well-known and ... with 30 years of practice experience in Dallas, Texas, ... benefits of dietary detoxification. The second study is scheduled ... results from test patients who just completed a 21-day ... interest in conducting the study, Dr. Casad said, "About ...
(Date:12/24/2014)... 2014 Dr. Vu Ho, a Dallas ... his practice and med-spa with the addition of new ... of cosmetic treatments and services. , “Silk Peel is ... says Dr. Ho. “As a result it can address ... sun spots, discolorations or blemishes.” , Similar to microdermabrasion, ...
(Date:12/24/2014)... Dallas, TX (PRWEB) December 25, 2014 ... Analysis to 2023” focuses on the current treatment landscape, ... colorectal cancer market. Stivarga is a drug which is ... This drug is orally administered and is also prescribed ... The drug which is FDA approved is a multi-kinase ...
(Date:12/24/2014)... 24, 2014 (HealthDay News) -- The holidays can be a ... off by certain foods and drinks. "This is the ... trigger attacks of migraine," Dr. David Dodick, chair of the ... foundation. "It,s important to think through food and beverage ... attack," added Dodick, a professor of neurology at the Mayo ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Expert Offers Tips for Preventing Holiday Migraines 2
... 15th, on Capitol Hill, the Center for Medicine in ... a question-and-answer session for media and Congressional Staff entitled: ... Experts Discuss Patient Safety." The event will be co-hosted ... Commerce Committee, Congresswoman Anna Eshoo (D-CA) and Congressman Mike ...
... have long been committed to expanding coverage to the millions ... know all too well what lack of coverage means for ... rooms every day. As a nation, we know we can ... with Chairman Baucus and the Obama Administration to move comprehensive ...
... ANGELES, July 8 Social Compassion in Legislation ... pet overpopulation through legislation, today reported that the total ... municipal shelters increased 14.6 percent statewide - from 378,445 ... released figures from the California Department of Public Health ...
... , WASHINGTON, July 8 Today, the American Hospital ... announced an agreement with the White House and Senate ... spending by $155 billion. Cost savings is an ... the national association representing physician owned hospitals. As always, ...
... says, , WEDNESDAY, July 8 (HealthDay News) -- Scientists ... monoclonal antibody drug might safely cure anthrax poisoning in ... they are not effective in killing the toxins produced ... those toxins once they enter the bloodstream. After an ...
... 8 Watson Pharmaceuticals, Inc. (NYSE: WPI ... today announced that its subsidiary, Watson Laboratories, Inc., has ... Administration to market its over-the-counter Nicotine Polacrilex Gum USP, ... fruit and cinnamon flavors. , , Nicotine Polacrilex ...
Cached Medicine News:Health News:CMPI to Host Hill Briefing on Follow-On Biologic Drugs for Media and Congressional Staff with Reps. Eshoo and Rogers 2Health News:Statement About Agreement With White House and Senate Finance Committee on Health Reform 2Health News:California Department of Public Health Reports Large Increase in Pet Euthanasia 2Health News:California Department of Public Health Reports Large Increase in Pet Euthanasia 3Health News:Physician Hospitals of America Charges: Hospital Associations Bargain Away $155 Billion in Medicare Funding in Attempt to Destroy Physician Hospitals 2Health News:Physician Hospitals of America Charges: Hospital Associations Bargain Away $155 Billion in Medicare Funding in Attempt to Destroy Physician Hospitals 3Health News:New Drug Fights Anthrax Toxin 2Health News:New Drug Fights Anthrax Toxin 3Health News:Watson Pharmaceuticals Receives FDA Approval for Fruit and Cinnamon Flavored Coated Nicotine Gums 2
(Date:12/24/2014)...  Lockton Dunning Benefits, the Dallas ... addition of Vice President Kim Foerster ... Consulting team, Excelsior Solutions. Foerster ... the position.  Most recently, she worked as the ... Pharmacy, where she has held various managerial positions ...
(Date:12/24/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE MKT: ... biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... the Company achieved the Public Notice (Gong Shi) ... of TPI,s Qionglai Facility (QLF) from the China ... period is a significant procedure of GMP certification ...
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... May 2, 2011 Valeant Pharmaceuticals International, Inc. (NYSE: ... Ltd. (NASDAQ: TEVA ) and Cephalon, Inc. (NASADQ: ... acquired by Teva.  In response to the news, Valeant has ... this announcement is positive news for Cephalon stockholders and we ...
... SAN JOSE, Calif., May 2, 2011 EMBEDDED SYSTEMS ... company, announces the availability of Prism FP ™ , ... lossless compression of floating point data types.   ... thousands or tens of thousands of computing nodes poses ...
Cached Medicine Technology:Valeant Pharmaceuticals Congratulates Teva and Cephalon on Their Transaction 2Samplify Systems Announces Availability of Prism FP Floating Point Compression 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: