Navigation Links
Schizophrenia linked to signaling problems in new brain study
Date:3/3/2009

Schizophrenia could be caused by faulty signalling in the brain, according to new research published today in the journal Molecular Psychiatry. In the biggest study of its kind, scientists looking in detail at brain samples donated by people with the condition have identified 49 genes that work differently in the brains of schizophrenia patients compared to controls.

Many of these genes are involved in controlling cell-to-cell signalling in the brain. The study, which was carried out by researchers at Imperial College London and GlaxoSmithKline, supports the theory that abnormalities in the way in which cells 'talk' to each other are involved in the disease.

Schizophrenia is thought to affect around one in 100 people. Symptoms vary but can include hallucinations, lack of motivation and impaired social functioning. The disorder has little physical effect on the brain and its causes are largely unknown.

Some scientists believe that schizophrenia could be caused by the brain producing too much dopamine, partly because drugs that block dopamine action provide an effective treatment for the condition. Another theory is that the coat surrounding nerve cells, which is made of myelin, is damaged in people with schizophrenia. However, the new study found that the genes for dopamine and for myelin were not acting any differently in schizophrenia patients compared with controls.

Professor Jackie de Belleroche, the corresponding author of the paper from Imperial College London said: "The first step towards better treatments for schizophrenia is to really understand what is going on, to find out what genes are involved and what they are doing. Our new study has narrowed the search for potential targets for treatment."

As well as pointing towards signalling as the cause of schizophrenia, the new findings could also lead to new ways of diagnosing the condition. At the moment, patients are diagnosed on the basis of their behaviour.

"Most patients are diagnosed as teenagers or in their early 20s, but if they could be diagnosed earlier, they could be treated more effectively and they could have a better quality of life. To have the possibility of transforming someone's life early on instead of having to take drugs indefinitely would be wonderful," added Professor de Belleroche.

The researchers reached their conclusions after analysing brain tissue from 23 controls and 28 schizophrenia patients, selected from brains donated by UK patients being treated for schizophrenia and comparing the data to an equivalent study in the USA. The changes described in this study were common to both studies. This is the biggest cohort of schizophrenia patients used for this type of study to date.

This is part of a larger study looking at proteins and DNA as well as mRNA in the samples, which were taken from two brain regions associated with schizophrenia: the frontal cortical area and the temporal cortex. mRNA are copies of small sections of our DNA that cells use to build proteins. Unlike DNA, mRNA varies in different parts of the body, where different proteins are needed.


'/>"/>

Contact: Lucy Goodchild
lucy.goodchild@imperial.ac.uk
44-020-759-46712
Imperial College London
Source:Eurekalert

Related medicine news :

1. A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe
2. New Research Study in Houston, Texas Seeks Improved Quality of Life for People in the Future with Schizophrenia
3. Genome Study Points to New Culprit for Schizophrenia
4. Johns Hopkins researchers discover new schizophrenia gene
5. Altered brain activity in schizophrenia may cause exaggerated focus on self
6. People With Schizophrenia Say Bias Is Part of Their Lives
7. Common Genes Link Bipolar Disorder, Schizophrenia
8. Compound Tied to Cognitive Deficits in Schizophrenia
9. Glutamate: Too much of a good thing in schizophrenia?
10. Anti-inflammatory medications may become a treatment for schizophrenia
11. New candidate genes for schizophrenia identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: