Navigation Links
Schizophrenia candidate genes affect even healthy individuals
Date:9/27/2007

Philadelphia, PA, September 26, 2007 Do gene variants that convey risk for schizophrenia affect apparently healthy individuals" Although these genes are present in every human, individuals may have different versions of these genes, called alleles. While many people who possess these risk alleles do not end up with schizophrenia, this does not mean they are unaffected by the presence of the risk allele. In the largest study of its kind to date, scheduled for publication in the October 1st issue of Biological Psychiatry, researchers sought to examine the impact of a few particular genes, known to be associated with a diagnosis of schizophrenia, on a healthy population.

Stefanis and colleagues recruited more than 2000 young men and measured dimensions of their cognitive abilities that tend to be impaired in individuals diagnosed with schizophrenia. The authors also measured schizotypal personality traits, which represent behaviors that are associated with schizophrenia, such as atypical behaviors and beliefs, suspiciousness or paranoia, and discomfort in social situations. They then genotyped these volunteers in relation to the four most prominent schizophrenia candidate genes: Neuregulin1 (NRG1), Dysbindin (DTNBP1), D-amino-acid oxidase activator (DAOA), and D-amino-acid oxidase (DAAO). According to Nicholas Stefanis, the lead author on the paper, their study showed that apparently normal individuals who posses several risk alleles within these susceptibility schizophrenia genes, have indeed minute decrements in cognitive ability such as decreased attentional capacity and worse performance on memory tasks, and alterations in schizotypal beliefs and experiences. In other words, they found that the healthy individuals who possessed the risk variants within the DNTBP1, NRG1, and DAAO genes exhibited small reductions in their cognitive performance and had atypical experiences that might be associated with schizophrenia.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, notes: The genetics of schizophrenia is turning out to be a complicated story involving many so-called risk gene variants that are actually commonly present in the general population, i.e., people who do not have schizophrenia and will never develop this disorder. It is striking that these genes all effect the glutamate system in the brain. Glutamate is the main excitatory chemical messenger used by the cerebral cortex. Thus, this paper highlights a role for glutamate in the development of schizophrenia-like symptoms, attention deficits, and memory problems. This genetic information adds to a growing body of evidence that highlights the potential importance of glutamate systems as a target for new medications for the treatment of schizophrenia.

Dr. Stefanis, explaining the importance of this study, comments that these findings support the notion that even at the general population level, the genetic liability to psychosis may be expressed as minute and undetected to the naked eye alterations in brain information processing capacity and behavior. Dr. Krystal adds, Consistent with a growing body of evidence, this study suggests that there may be subtle cognitive impairments that are present when these common risk gene variants are present in the general population. Clearly, these findings will have an important impact on the future genetic work in this area.


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Identifying The Risks Of Developing Schizophrenia
2. Sex exploitation connected to Schizophrenia
3. Schizophrenia detected early
4. No explanation on schizophrenia gene
5. Gene glitches connecting pot with Schizophrenia
6. An insight about Schizophrenia
7. Risk Of Schizophrenia due to Gene Variation
8. Factors That Might Increase The Risk Of Schizophrenia
9. Dads Age Found To Affect The Childs Risk for Schizophrenia
10. Famine May Be A Cause For Schizophrenia
11. Schizophrenia Gets A New Diagnostic Tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... Tx (PRWEB) , ... April 24, 2017 , ... ... Lief Therapeutics designed to recognize elevated anxiety levels in people with addiction who ... the Lief Smart Patch, a biosensing wearable device that monitors heart and breath ...
(Date:4/24/2017)... ... April 24, 2017 , ... Come to PAINWeekEnd (PWE) Tampa on ... Blvd, for an educational and exciting 2-day program. , An attendee at a ... before they approach patients” about the course entitled Ain't Misbehavin': Decreasing and Managing Pain ...
(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each ... published author, Jerri Broglin, a survivor of great loss who gained insight on how ... for those searching for answers, as we are finding the answers that are so ...
(Date:4/24/2017)... Gainesville, Florida (PRWEB) , ... April 24, 2017 , ... ... at the University of Florida. The event will be held at 7:30 pm on ... and Ken Block and Drew Copeland of Sister Hazel, will support the UF Collegiate ...
(Date:4/23/2017)... ... 23, 2017 , ... "An event Horizon is a place where the laws ... Art and Music. These are created as Metaphysical Transformations where music, which is the ... to the ultimate singularity.", -- Karen Salicath Jamali , Karen will also preview her ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., ... case series to be presented at the 2017 National ... begins today and continues through April 22. Physicians will ... , used to assess risk for acute kidney injury ... heart failure (ADHF). Elevated levels of ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc. ... collaboration started in 2016, in which Socionext extracts ... SOINN". The companies achieved initial results in reading ... by Artificial Brain SOINN. The results will be ... Sight, April 19-21, at booths 4505 & 4507. ...
(Date:4/18/2017)... 2017  Spero Therapeutics, LLC, a biopharmaceutical company founded ... infections, will present preclinical data supporting the use of ... (MDR) Gram-negative infections at the 27th European Congress of ... in Vienna, Austria . ... "Our ongoing preclinical ...
Breaking Medicine Technology: