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Schizophrenia Gene's Role May Be Broader, More Potent, than Thought
Date:11/19/2009

kably normal.

Davis has explored this and related phenomena at the neuromuscular junction in the fruit fly, or Drosophila melanogaster. He’s been asking how neural function is stabilized but also how the physical connections between nerve cells are stabilized and maintained throughout life. He would like to understand how this process sometimes fails, leading to neurodegeneration, such as occurs in amyotrophic lateral sclerosis, or ALS.

“It’s become clear that the nervous system is remarkably stable, but not as one might suspect,” says Davis. “It is continuously responsive to a changing environment, which allows us to learn and remember and to respond to environmental change. There probably are many processes that are sensing the environment, continually updating neural function and neural structure in order to keep the brain stable. If we can understand how stability is maintained in the nervous system, perhaps we could understand what happens when stability is lost and disease ensues.”

“These are big questions that reach far beyond our current understanding of brain function,” he says. “This is the power and importance of basic science. By studying fundamental questions, you can discover unexpected phenomenon and also create new perspectives for understanding existing diseases, even if the human genes are known.” The new finding, he says, “may add a new dimension to the conversation about the origins of schizophrenia.”

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Related links:
Davis lab: http://biochemistry.ucsf.edu/labs/davis/

Source: Jennifer O’Brien (415)
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