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Schizophrenia Gene May Have On/Off Switch
Date:9/11/2007

o proteins -- 25 kDa synaptosome-associated protein (SNAP-25) and lissencephaly-1, which are both known to be important to brain cell development and growth. Prior studies of human brain tissue has shown abnormal levels of SNAP-25 as well.

"This model supports the idea that schizophrenia is a disease associated with abnormal brain development," senior co-author of the study Dr. Christopher Ross said in a prepared statement. "Being able to regulate the timing of expression of the mutant protein provides an opportunity to study the timing and mechanism of specific abnormalities -- a tool that could eventually lead to the discovery of drugs that could potentially control or even prevent the disease," he said.

The study is published in the September issue of Molecular Psychiatry.

More information

To learn about schizophrenia, visit the National Alliance on Mental Illness.



-- Madeline Vann



SOURCE: Johns Hopkins University, news release, Sept. 10, 2007


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