Navigation Links
Saving teeth by using periodontal ligament regeneration
Date:6/4/2008

Teeth may fall out as a result of inflammation and subsequent destruction of the tissues supporting the teeth. Dutch researcher Agnes Berendsen has investigated a possible solution to this problem. At the Academic Centre for Dentistry Amsterdam (ACTA), she has studied the regeneration of the periodontal ligament by use of tissue engineering. The 3D in vitro model she has developed appears to be promising for regenerating periodontal ligament and may also prove valuable for restoring tendons and ligaments elsewhere in the body.

The periodontal ligament forms a flexible connection between the tooth root and the surrounding jaw bone. Trauma or inflammation can cause destruction of the periodontal ligament. Berendsen chose tissue engineering to tackle this problem. Research in tissue engineering uses cells placed in a 3D model, after which signals are applied to activate the cells. Berendsen developed a new 3D model in which cells isolated from periodontal ligament were implanted in a collagen network suspended between an artificial root and artificial bone. She wanted to see if viable periodontal ligament could be generated in this way.

The composition of the collagen network in which the cells are located has a considerable influence on the contractile properties of the cells. Contraction of the cells creates internal tension in the network which keeps the cells active. The network must be well attached to the surrounding solid surfaces to prevent its detachment. Berendsen managed to attach the network to these artificial root and bone surfaces present in the model by creating an enzyme-mediated mineral deposition on the surfaces. By subsequently applying loading to the tooth root (mimicking the process of chewing) in the 3D model, she was able to deform the mineral-anchored network containing the cells. The subsequent response of the cells was dependent on the magnitude of the loading.

Follow-up research will investigate whether the cell-culture results can be translated to an animal model to obtain more accurate insights concerning the potential use of this method in humans.


'/>"/>

Contact: Agnes Berendsen
a.berendsen@vumc.nl
31-204-448-663
Netherlands Organization for Scientific Research
Source:Eurekalert

Related medicine news :

1. Over 500,000 Health Care Providers Now Cutting Costs, Saving Time Through CAQH Administrative Simplification Initiative
2. Life-Saving News for Battlefield Soldiers & Wounded Civilians
3. E-Prescribing Saving Mississippi Medicaid $1.2 Million Per Month
4. Class Settlement Could Result in Considerable Savings for Certain Consumers of Prescription Pharmaceuticals
5. ABC TV San Francisco Features Canine Cancer Research Story: Saving Our Dogs, Helping Humans Beat Cancer - Work at Morris Animal Foundation, UC-Davis
6. People With Chronic Conditions Experience Additional Benefits of Cost Savings by Wearing a Medical ID
7. Ericom Provides Significant Cost-Savings for Major New York City Healthcare Organization
8. The G&P Foundation Celebrates 10 Years of Funding Life Saving Research at The 2007 Angel Ball Honoring Glenda Bailey, Debra L. Lee, Dr. Stephen D. Nimer and the Late H.H. Sheik Zayed Bin Sultan Al Nahyan
9. Saving Millions of Childrens Lives Is Possible
10. Committee to Reduce Infection Deaths Releases 10 Lifesaving Steps to Protect Students from MRSA Infections
11. Bodys Clock Never Adjusts to Daylight Savings Time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: