Navigation Links
Save messengers -- modified mRNAs open up new therapeutic possibilities
Date:2/7/2011

Defects in the genome are the cause of many diseases. Gene therapy direct replacement of mutant genes by intact DNA copies offers a means of correcting such defects. Now a research team based at the Medical Center of the University of Munich, and led by Privatdozent Dr. Carsten Rudolph, has taken a new approach that avoids DNA delivery. The team shows for the first time that chemical modification of mRNAs (the metabolically active molecules derived from genomic DNA that programs protein synthesis) provides a promising alternative to DNA-based procedures. In contrast to the latter, the modified RNAs do not increase the risk of cancer, and do not induce frequently observed severe immune reactions seen with DNA or unmodified mRNA. The researchers show that the new method is life-saving in mice with a congenital lethal lung defect. "These results clearly demonstrate the therapeutic potential of our mRNAs," says Rudolph. (Nature Biotechnology, 7 February 2011)

Gene therapy offers great potential for the treatment of both congenital and acquired diseases that are otherwise not amenable to other treatments. However, the approaches that have been tested so far are associated with serious side-effects. The use of engineered viruses to introduce intact genes into the cellular genome are associated with an increased risk of developing leukaemia, and can provoke strong immune reactions. Nonviral vectors, on the other hand, tend to be inefficient delivery vehicles. The new RNA-based method displays neither of these disadvantages. "Chemical modification of the mRNA prevents it from activating the immune system, so that no inflammatory reaction ensues," says Rudolph. "Furthermore, in contrast to conventional mRNA, the modified mRNA can be administered repeatedly, is more stable and is effective at very low doses."

The new method, referred to as Transcript Therapy by its inventors, opens up new opportunities for targeted treatments. The modified mRNA
'/>"/>

Contact: Dr. Carsten Rudolph
Carsten.Rudolph@med.uni-muenchen.de
49-895-160-7711
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH Stem Cell Guidelines Should Be Modified, UCSF Team Reports
2. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
3. New On the Menu: Genetically Modified Salmon?
4. FDA Advisers Weigh Approval of Genetically Modified Salmon
5. FDA Advisers Consider Approval of Genetically Modified Salmon
6. Consumer Activists Want Modified Salmon to Be Labeled
7. New therapeutic target for most common solid cancer in childhood?
8. UC studies show marijuana has therapeutic value, reports to legislature
9. United Therapeutics Corporation Withdraws European Marketing Authorization Application for Tyvaso for the Treatment of Pulmonary Arterial Hypertension
10. Elements Therapeutic Massage Announces Franchise Expansion Plan for Massachusetts
11. Castrate-Metastatic Prostate Cancer: Therapeutic Considerations for Advanced Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... associate professor of chemical engineering at Virginia Tech ... efficiently analyze living cells. The long-term goal is to ... , In his lab , Lu and his ... molecular events inside cells. These devices promote high sensitivity ... of cells. , Based on their record of achievements, ...
(Date:4/14/2014)... with beliefs about health that aren,t based on medical ... rehabilitation, new research suggests. , In the Ohio State ... referred to as "irrational health beliefs" on a standard ... adherence to a prescribed cardiac rehab program. , ... of the flu vaccine or believing, based on family ...
(Date:4/14/2014)... abuse is closely linked to postpartum mental health ... in mothers. The research also found that specific ... health problems. The work was done by researchers ... and the University of British Columbia. , "We ... abuse physical, psychological and sexual influenced ...
(Date:4/14/2014)... cancer, chemotherapy before or after surgery is not ... are published early online in Cancer , ... , Clinical trials have shown that survival is ... are given chemotherapy before surgery. There is less ... survival. To investigate the use of peri-operative chemotherapy ...
(Date:4/13/2014)... An expert task force has created a new definition ... with this brain disease. The study published in ... of the International League Against Epilepsy (ILAE), provides a ... individuals with two unprovoked seizures, and those with one ... seizure recurrence. , The 2005 report by the ...
Breaking Medicine News(10 mins):Health News:Efficient analysis of small quantity of cells improves chances to understand disease 2Health News:Irrational health beliefs linked to skipping cardiac rehab sessions 2Health News:Irrational health beliefs linked to skipping cardiac rehab sessions 3Health News:Study links domestic abuse to mental health problems in new mothers 2Health News:New clinical definition for epilepsy improves diagnosis accuracy 2
... Measurements , New web-based research has quantified the attractiveness ... manipulated the features of one woman into 243 variations ... and waist widths. Then more than 34,000 people judged ... remained exactly the same in all of the photos, ...
... Old Republic International Corporation (NYSE: ORI ... the payment of the regular quarterly cash dividend of 17 ... March 13, 2009 to shareholders of record on March 4, ... rate initially approved for the second quarter of 2008. ...
... Global Prevention Network(TM) as Asian AffiliateNEW YORK and ... leader in disease prevention services, has signed an ... a leading healthcare group based in Singapore and ... participate in preventive medicine programs throughout Asia. Under ...
... conducted with 274 adults with intellectual disabilities currently ... , Washington, DC(February 23, 2009)The ... predict funding for people with intellectual disability based ... needs-based assessment tool, unlike adaptive behavior instruments or ...
... UCSF-Gladstone Institute for Virology and Immunology Center for AIDS ... the next generation of HIV/AIDS researchers and clinician scientists. ... the American Journal for Public Health appearing ... AJPH website, the program focuses on overcoming challenges faced ...
... NYSE: ABT ),today announced that it has completed its acquisition ... owned subsidiary of Abbott and has been,renamed Abbott Medical Optics ... enhances and strengthens Abbott,s diverse mix of,medical device businesses and ... care market. Abbott Medical Optics holds the number one ...
Cached Medicine News:Health News:Plastic and reconstructive surgery ... in brief 2Health News:U.S. Preventive Medicine(R), ParkwayHealth Sign Affiliation Agreement to Jointly Deliver Preventive Medicine Services in Asia 2Health News:U.S. Preventive Medicine(R), ParkwayHealth Sign Affiliation Agreement to Jointly Deliver Preventive Medicine Services in Asia 3Health News:Supports Intensity Scale is effective for identifying needs in people with intellectual disability 2Health News:Effective mentoring critical to HIV/AIDS research efforts 2Health News:Abbott Completes Acquisition of Advanced Medical Optics 2
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... to its store . (Photo: ... of population, consumption upgrade and policy support, ... seen rapid development over the years, with total ... 2006 to 9.85 billion yuan in 2012. ...
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( ... "Dental Consumables Market - Global Industry Analysis, ... 2018" report to their offering. ... Dental consumables are products which are used ... for tooth restoration and in treatment of associated ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today ... to support older adults suffering from the severe cold ... and its members are committed to helping those in ... and AARP Foundation will match dollar-for-dollar contributions up to ... The matching program will be administered through AARP Foundation. ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... , , , COLUMBIA, S.C. ... home pilot project that could become a model for South Carolina ... also attracting the attention of S.C. physicians not involved in the ... to managing their health care costs. , , ...
... , ANN ARBOR, Mich., July 24 Terumo ... Phase II Clinical Trial for the Anaconda(TM) AAA (Abdominal Aortic ... system is manufactured by Scotland-based Terumo subsidiary Vascutek Ltd. ... at Arizona Heart Hospital by the principal investigator, Julio Rodriguez-Lopez, ...
Cached Medicine Technology:S.C. Medical Home Pilot for Diabetes Enrolls 1,110 2S.C. Medical Home Pilot for Diabetes Enrolls 1,110 3Terumo Cardiovascular Systems Initiates U.S. Clinical Trial for Anaconda(TM) AAA Stent Graft System 2
The GE e-Speed™scanner, the worlds fastest computed tomography (CT) imaging platform, delivers a new advanced tool for physicians to see and diagnose heart disease....
...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right;) overall length 120mm; Stainless ...
16mm Slightly Curved sharp Tips; overall length 120mm; Stainless Steel...
Medicine Products: