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Sanofi-aventis Q3 2008 Adjusted EPS Excluding Selected Items(1):
Date:10/31/2008

R 1,745 million.

The third quarter reaffirmed the good performance of Taxotere(R), which achieved double-digit growth in all three geographic regions. In the United States, net sales were up 16.8% at EUR 181 million, driven by the use of the product in adjuvant breast cancer treatment and in prostate cancer. Furthermore, U.S. sales also benefited from a new indication, obtained in May 2008, as an adjuvant treatment for HER2-positive breast cancer in combination with Herceptin(R). Taxotere(R) achieved third-quarter net sales growth of 10.2% in Europe (to EUR 227 million) and of 14.1% in the Other Countries region (to EUR 97 million). During the third quarter, Taxotere(R) obtained approval in Japan as a treatment for prostate cancer. Over the first nine months of the year, Japanese sales of the product increased 11.3% to EUR 68 million. Overall net sales of Taxotere(R) for the nine months to end September were up 13.5% at EUR 1,492 million.

In the United States, third-quarter net sales of Ambien CR(R) and Ambien(R) IR totaled $177 million and $28 million respectively. In Japan, Myslee(R), the leading hypnotic in the market, achieved net sales of EUR 33 million in the third quarter (up 15.9%) and of EUR 94 million over the first nine months of 2008 (up 13.5%); these sales have been consolidated by sanofi-aventis since January 1, 2008. Over the nine months to end September 2008, net sales of Ambien CR(R) totaled $511 million, against $561 million for the comparable period of 2007.

Net sales of Eloxatin(R), the leading cytotoxic agent in adjuvant and in first line metastatic colorectal cancer, rose 7.8% in the third quarter to EUR 234 million in the United States, driven by the product's use as an adjuvant. At end July 2008, penetration of Eloxatin(R) in the U.S. market as an adjuvant stage III treatment had reached 76% in terms of the number of patients (source: IntrsiQ Research).

The introduction of generics in Europe again weighed on net sa
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