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Sanofi-aventis Delivers 2008 Results Above Guidance
Date:2/11/2009

irbesartan is protected by a patent in the principal European countries until August 2012. In some countries (Spain, Portugal, Finland, Norway, and some Eastern European countries), irbesartan is not protected by this active ingredient patent, though other patents may be in force locally. Net sales of Aprovel(R) as a monotherapy in European countries not covered by the active ingredient patent were approximately EUR 50 million in 2008.

Human Vaccines

Fourth-quarter consolidated net sales for the Human Vaccines business were up 8.9% at EUR 709 million, with full-year growth reaching 9.6% at EUR 2,861 million. In the United States, 2008 full-year net sales were up 9.7% at EUR 1,683 million.

Net sales of influenza vaccines in 2008 rose 1.5% to EUR 736 million. This increase includes the shipment during the second quarter of a batch of H5N1 vaccine to the U.S. Department of Health and Human Services worth $192.5 million (vs. $113 million in 2007). Fourth-quarter sales of influenza vaccines in the United States were down compared to previous year, as three-quarters of 2008 shipments were completed during the third quarter of the year.

Net sales of Menactra(R) (quadrivalent meningococcal meningitis vaccine) rose 7.9% in 2008 at EUR 404 million.

Pentacel(R) -- the first 5-in-1 pediatric combination vaccine to protect against diphtheria, tetanus, pertussis, polio and haemophilus influenzae type b licensed in the United States-- confirmed its success with strong sales uptake promptly after its launch in July 2008, reaching net sales of EUR 56 million in the fourth quarter and EUR 82 million in 2008.

Adacel(R) (adult and adolescent tetanus-diphtheria-pertussis booster) continued to perform very well in the United States, up 35.6% in the fourth quarter to EUR 54 million and by 20.0% for the year, reaching EUR 255
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